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Array technology as a tool to monitor exposure of fish to xenoestrogens

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Title: Array technology as a tool to monitor exposure of fish to xenoestrogens
Authors: Larkin, Patrick1, Folmar, Leroy C.2, Hemmer, Michael J.2, Poston, Arianna J.1, Stephen Lee, H.1, Denslow, Nancy D.1
Source: Marine Environmental Research. Sep2002, Vol. 54 Issue 3-5, p395. 5p.
Subjects: Estrogen, Endocrine genetics, Messenger RNA
Abstract: A variety of anthropogenic chemicals are capable of binding to the estrogen receptor of vertebrate species. Binding of these compounds can interfere with homeostasis by disrupting normal gene expression patterns. The purpose of this study was to investigate the feasibility of applying array technology as a monitoring tool for detecting the presence and distribution of estrogenic compounds in coastal habitats using sheepshead minnows as our model. cDNA clones that were isolated from differential display, including vitellogenin α and β, vitelline envelope protein (ZP2), and transferrin, among others, were spotted on the macroarray. The results of these experiments demonstrate a characteristic expression pattern of estrogen responsive genes in sheepshead minnows exposed to 17 β-estradiol (E2). [Copyright &y& Elsevier]
Copyright of Marine Environmental Research is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 7872641
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: <searchLink fieldCode="DE" term="%22Estrogen%22">Estrogen</searchLink><br /><searchLink fieldCode="DE" term="%22Endocrine+genetics%22">Endocrine genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Messenger+RNA%22">Messenger RNA</searchLink>
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  Label: Abstract
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  Data: A variety of anthropogenic chemicals are capable of binding to the estrogen receptor of vertebrate species. Binding of these compounds can interfere with homeostasis by disrupting normal gene expression patterns. The purpose of this study was to investigate the feasibility of applying array technology as a monitoring tool for detecting the presence and distribution of estrogenic compounds in coastal habitats using sheepshead minnows as our model. cDNA clones that were isolated from differential display, including vitellogenin α and β, vitelline envelope protein (ZP2), and transferrin, among others, were spotted on the macroarray. The results of these experiments demonstrate a characteristic expression pattern of estrogen responsive genes in sheepshead minnows exposed to 17 β-estradiol (E2). [Copyright &y& Elsevier]
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  Data: <i>Copyright of Marine Environmental Research is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/S0141-1136(02)00172-1
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      – Code: eng
        Text: English
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        Type: general
      – SubjectFull: Endocrine genetics
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      – SubjectFull: Messenger RNA
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      – TitleFull: Array technology as a tool to monitor exposure of fish to xenoestrogens
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            – D: 01
              M: 09
              Text: Sep2002
              Type: published
              Y: 2002
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