p38 MAPK mediates the regulation of α1(I) procollagen mRNA levels by TNF-α and TGF-β in a cell line of rat hepatic stellate cells11 The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense of the US.
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| Title: | p38 MAPK mediates the regulation of α1(I) procollagen mRNA levels by TNF-α and TGF-β in a cell line of rat hepatic stellate cells1 |
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| Authors: | Varela-Rey, M.1, Montiel-Duarte, C.1, Osés-Prieto, J.A.1, López-Zabalza, M.J.1, Jaffrèzou, J.P.2, Rojkind, M.3, Iraburu, M.J.1 miraburu@unav.es |
| Source: | FEBS Letters. Sep2002, Vol. 528 Issue 1-3, p133. 6p. |
| Subjects: | Tumor necrosis factors, Transforming growth factors-beta, Phosphorylation |
| Abstract: | The role of members of the mitogen-activated protein kinase (MAPK) family on tumor necrosis factor α (TNF-α)-mediated down-regulation of col1a1 gene was studied. TNF-α increased extracellular-regulated kinase and Jun-N-terminal kinase phosphorylation, but these effects were not related to its inhibitory effect on α1(I) procollagen (col1a1) mRNA levels. Phosphorylation of p38 MAPK was decreased in response to TNF-α, and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-α on col1a1 mRNA levels. Transforming growth factor β (TGF-β) increased p38 MAPK phosphorylation and SB203580 prevented the induction of col1a1 mRNA levels by TGF-β. These results suggest that p38 MAPK plays an important role in regulating the expression of col1a1 in hepatic stellate cells in response to cytokines. [Copyright &y& Elsevier] |
| Copyright of FEBS Letters is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 7882036 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: p38 MAPK mediates the regulation of α1(I) procollagen mRNA levels by TNF-α and TGF-β in a cell line of rat hepatic stellate cells<superscript>1</superscript><FN ID="FN1"><NO>1</NO>The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense of the US.</FN> – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Varela-Rey%2C+M%2E%22">Varela-Rey, M.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Montiel-Duarte%2C+C%2E%22">Montiel-Duarte, C.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Osés-Prieto%2C+J%2EA%2E%22">Osés-Prieto, J.A.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22López-Zabalza%2C+M%2EJ%2E%22">López-Zabalza, M.J.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Jaffrèzou%2C+J%2EP%2E%22">Jaffrèzou, J.P.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Rojkind%2C+M%2E%22">Rojkind, M.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Iraburu%2C+M%2EJ%2E%22">Iraburu, M.J.</searchLink><relatesTo>1</relatesTo><i> miraburu@unav.es</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22FEBS+Letters%22">FEBS Letters</searchLink>. Sep2002, Vol. 528 Issue 1-3, p133. 6p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Tumor+necrosis+factors%22">Tumor necrosis factors</searchLink><br /><searchLink fieldCode="DE" term="%22Transforming+growth+factors-beta%22">Transforming growth factors-beta</searchLink><br /><searchLink fieldCode="DE" term="%22Phosphorylation%22">Phosphorylation</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The role of members of the mitogen-activated protein kinase (MAPK) family on tumor necrosis factor α (TNF-α)-mediated down-regulation of col1a1 gene was studied. TNF-α increased extracellular-regulated kinase and Jun-N-terminal kinase phosphorylation, but these effects were not related to its inhibitory effect on α1(I) procollagen (col1a1) mRNA levels. Phosphorylation of p38 MAPK was decreased in response to TNF-α, and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-α on col1a1 mRNA levels. Transforming growth factor β (TGF-β) increased p38 MAPK phosphorylation and SB203580 prevented the induction of col1a1 mRNA levels by TGF-β. These results suggest that p38 MAPK plays an important role in regulating the expression of col1a1 in hepatic stellate cells in response to cytokines. [Copyright &y& Elsevier] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of FEBS Letters is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/S0014-5793(02)03276-3 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 133 Subjects: – SubjectFull: Tumor necrosis factors Type: general – SubjectFull: Transforming growth factors-beta Type: general – SubjectFull: Phosphorylation Type: general Titles: – TitleFull: p38 MAPK mediates the regulation of α1(I) procollagen mRNA levels by TNF-α and TGF-β in a cell line of rat hepatic stellate cells1<FN ID="FN1"><NO>1</NO>The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense of the US.</FN> Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Varela-Rey, M. – PersonEntity: Name: NameFull: Montiel-Duarte, C. – PersonEntity: Name: NameFull: Osés-Prieto, J.A. – PersonEntity: Name: NameFull: López-Zabalza, M.J. – PersonEntity: Name: NameFull: Jaffrèzou, J.P. – PersonEntity: Name: NameFull: Rojkind, M. – PersonEntity: Name: NameFull: Iraburu, M.J. IsPartOfRelationships: – BibEntity: Dates: – D: 25 M: 09 Text: Sep2002 Type: published Y: 2002 Identifiers: – Type: issn-print Value: 00145793 Numbering: – Type: volume Value: 528 – Type: issue Value: 1-3 Titles: – TitleFull: FEBS Letters Type: main |
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