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A prototypic mathematical model of the human hair cycle

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Title: A prototypic mathematical model of the human hair cycle
Authors: Al-Nuaimi, Yusur1,2 yusur.al-nuaimi@manchester.ac.uk, Goodfellow, Marc1,3, Paus, Ralf2,4, Baier, Gerold1
Source: Journal of Theoretical Biology. Oct2012, Vol. 310, p143-159. 17p.
Subjects: Prototypes, Human hair color, Apoptosis, Hair cells, Mathematical models, Cell cycle, Population dynamics, Stem cells
Abstract: Abstract: The human hair cycle is a complex, dynamic organ-transformation process during which the hair follicle repetitively progresses from a growth phase (anagen) to a rapid apoptosis-driven involution (catagen) and finally a relative quiescent phase (telogen) before returning to anagen. At present no theory satisfactorily explains the origin of the hair cycle rhythm. Based on experimental evidence we propose a prototypic model that focuses on the dynamics of hair matrix keratinocytes. We argue that a plausible feedback-control structure between two key compartments (matrix keratinocytes and dermal papilla) leads to dynamic instabilities in the population dynamics resulting in rhythmic hair growth. The underlying oscillation consists of an autonomous switching between two quasi-steady states. Additional features of the model, namely bistability and excitability, lead to new hypotheses about the impact of interventions on hair growth. We show how in silico testing may facilitate testing of candidate hair growth modulatory agents in human HF organ culture or in clinical trials. [Copyright &y& Elsevier]
Copyright of Journal of Theoretical Biology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 79185242
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: A prototypic mathematical model of the human hair cycle
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Theoretical+Biology%22">Journal of Theoretical Biology</searchLink>. Oct2012, Vol. 310, p143-159. 17p.
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  Data: <searchLink fieldCode="DE" term="%22Prototypes%22">Prototypes</searchLink><br /><searchLink fieldCode="DE" term="%22Human+hair+color%22">Human hair color</searchLink><br /><searchLink fieldCode="DE" term="%22Apoptosis%22">Apoptosis</searchLink><br /><searchLink fieldCode="DE" term="%22Hair+cells%22">Hair cells</searchLink><br /><searchLink fieldCode="DE" term="%22Mathematical+models%22">Mathematical models</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+cycle%22">Cell cycle</searchLink><br /><searchLink fieldCode="DE" term="%22Population+dynamics%22">Population dynamics</searchLink><br /><searchLink fieldCode="DE" term="%22Stem+cells%22">Stem cells</searchLink>
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  Data: Abstract: The human hair cycle is a complex, dynamic organ-transformation process during which the hair follicle repetitively progresses from a growth phase (anagen) to a rapid apoptosis-driven involution (catagen) and finally a relative quiescent phase (telogen) before returning to anagen. At present no theory satisfactorily explains the origin of the hair cycle rhythm. Based on experimental evidence we propose a prototypic model that focuses on the dynamics of hair matrix keratinocytes. We argue that a plausible feedback-control structure between two key compartments (matrix keratinocytes and dermal papilla) leads to dynamic instabilities in the population dynamics resulting in rhythmic hair growth. The underlying oscillation consists of an autonomous switching between two quasi-steady states. Additional features of the model, namely bistability and excitability, lead to new hypotheses about the impact of interventions on hair growth. We show how in silico testing may facilitate testing of candidate hair growth modulatory agents in human HF organ culture or in clinical trials. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Journal of Theoretical Biology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.jtbi.2012.05.027
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      – Code: eng
        Text: English
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        PageCount: 17
        StartPage: 143
    Subjects:
      – SubjectFull: Prototypes
        Type: general
      – SubjectFull: Human hair color
        Type: general
      – SubjectFull: Apoptosis
        Type: general
      – SubjectFull: Hair cells
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      – SubjectFull: Mathematical models
        Type: general
      – SubjectFull: Cell cycle
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      – SubjectFull: Population dynamics
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      – SubjectFull: Stem cells
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      – TitleFull: A prototypic mathematical model of the human hair cycle
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              Text: Oct2012
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              Value: 310
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