View in EDS

Stoichiometry and equilibrium constant of the complex of PAMAM-NH2 G4 and 5-fluorouracil

Saved in:
Bibliographic Details
Title: Stoichiometry and equilibrium constant of the complex of PAMAM-NH2 G4 and 5-fluorouracil
Authors: Buczkowski, Adam buczkowski_adam@tlen.pl, Piekarski, Henryk, Palecz, Bartlomiej paleczb@uni.lodz.pl
Source: Journal of Molecular Liquids. Sep2012, Vol. 173, p8-12. 5p.
Subjects: Stoichiometry, Fluorouracil, Dendrimers, Oncology, Drugs, Equilibrium constant (Chemistry), Polyamidoamine dendrimers, Complex compounds
Abstract: Abstract: Polyamidoamine dendrimer (PAMAM-NH2 G4) complex with 5-fluorouracil, an oncological drug, was investigated by the technique of equilibrium dialysis at temperatures of 20°C and 45°C. The results obtained were worked out by means of the modified model of two sets of active sites proposed by Bobrovnik. Based on the analysis of the results obtained, it was calculated that at a temperature of 20°C the dendrimer molecule can bind about 12 molecules of the ligand with equilibrium constant K 1 ≅5600 and about 37 molecules with equilibrium constant K 2 ≅150. At a temperature of 45°C the number of the dendrimer binding sites is similar but the equilibrium constants of binding 5-fluorouracil with both sets of active sites are clearly lower (K 1 ≅1820, K 2 ≅70). The saturation of both the sets of active sites is of an exothermic character. [Copyright &y& Elsevier]
Copyright of Journal of Molecular Liquids is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 79185929
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Stoichiometry and equilibrium constant of the complex of PAMAM-NH<subscript>2</subscript> G4 and 5-fluorouracil
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Buczkowski%2C+Adam%22">Buczkowski, Adam</searchLink><i> buczkowski_adam@tlen.pl</i><br /><searchLink fieldCode="AR" term="%22Piekarski%2C+Henryk%22">Piekarski, Henryk</searchLink><br /><searchLink fieldCode="AR" term="%22Palecz%2C+Bartlomiej%22">Palecz, Bartlomiej</searchLink><i> paleczb@uni.lodz.pl</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Journal+of+Molecular+Liquids%22">Journal of Molecular Liquids</searchLink>. Sep2012, Vol. 173, p8-12. 5p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Stoichiometry%22">Stoichiometry</searchLink><br /><searchLink fieldCode="DE" term="%22Fluorouracil%22">Fluorouracil</searchLink><br /><searchLink fieldCode="DE" term="%22Dendrimers%22">Dendrimers</searchLink><br /><searchLink fieldCode="DE" term="%22Oncology%22">Oncology</searchLink><br /><searchLink fieldCode="DE" term="%22Drugs%22">Drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Equilibrium+constant+%28Chemistry%29%22">Equilibrium constant (Chemistry)</searchLink><br /><searchLink fieldCode="DE" term="%22Polyamidoamine+dendrimers%22">Polyamidoamine dendrimers</searchLink><br /><searchLink fieldCode="DE" term="%22Complex+compounds%22">Complex compounds</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Abstract: Polyamidoamine dendrimer (PAMAM-NH2 G4) complex with 5-fluorouracil, an oncological drug, was investigated by the technique of equilibrium dialysis at temperatures of 20°C and 45°C. The results obtained were worked out by means of the modified model of two sets of active sites proposed by Bobrovnik. Based on the analysis of the results obtained, it was calculated that at a temperature of 20°C the dendrimer molecule can bind about 12 molecules of the ligand with equilibrium constant K 1 ≅5600 and about 37 molecules with equilibrium constant K 2 ≅150. At a temperature of 45°C the number of the dendrimer binding sites is similar but the equilibrium constants of binding 5-fluorouracil with both sets of active sites are clearly lower (K 1 ≅1820, K 2 ≅70). The saturation of both the sets of active sites is of an exothermic character. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Molecular Liquids is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=79185929
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.molliq.2012.06.005
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 5
        StartPage: 8
    Subjects:
      – SubjectFull: Stoichiometry
        Type: general
      – SubjectFull: Fluorouracil
        Type: general
      – SubjectFull: Dendrimers
        Type: general
      – SubjectFull: Oncology
        Type: general
      – SubjectFull: Drugs
        Type: general
      – SubjectFull: Equilibrium constant (Chemistry)
        Type: general
      – SubjectFull: Polyamidoamine dendrimers
        Type: general
      – SubjectFull: Complex compounds
        Type: general
    Titles:
      – TitleFull: Stoichiometry and equilibrium constant of the complex of PAMAM-NH2 G4 and 5-fluorouracil
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Buczkowski, Adam
      – PersonEntity:
          Name:
            NameFull: Piekarski, Henryk
      – PersonEntity:
          Name:
            NameFull: Palecz, Bartlomiej
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 09
              Text: Sep2012
              Type: published
              Y: 2012
          Identifiers:
            – Type: issn-print
              Value: 01677322
          Numbering:
            – Type: volume
              Value: 173
          Titles:
            – TitleFull: Journal of Molecular Liquids
              Type: main
ResultId 1