Low level laser therapy for concurrent chemoradiotherapy induced oral mucositis in head and neck cancer patients – A triple blinded randomized controlled trial
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| Title: | Low level laser therapy for concurrent chemoradiotherapy induced oral mucositis in head and neck cancer patients – A triple blinded randomized controlled trial |
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| Authors: | Gautam, Ajay Prashad1, Fernandes, Donald J.1, Vidyasagar, Mamidipudi S.2 vsagar32@yahoo.com, Maiya, Arun G.1, Vadhiraja, Bejadi M.3 |
| Source: | Radiotherapy & Oncology. Sep2012, Vol. 104 Issue 3, p349-354. 6p. |
| Subjects: | Medical lasers, Mucous membrane diseases, Randomized controlled trials, Head & neck cancer treatment, Cancer radiotherapy complications, Chemotherapy complications |
| Abstract: | Abstract: Background and purpose: Oral mucositis (OM) is most cumbersome acute side effect of concurrent chemoradiotherapy (CCRT) for head and neck cancer (HNC). OM associated pain affects oral functions and nutrition of the patient that may result in discontinuity of treatment. Several modalities have been tried to prevent and treat OM, but none proved completely successful until date. We used prophylactic low level laser therapy (LLLT) for the prevention and treatment of CCRT induced OM. Materials and methods: In this triple blinded study, 221 HNC patients scheduled to undergo CCRT (Cisplatin (1, 22, 43day)+RT=66 Grays (2Gy/fraction), 33 fractions, 5 fractions/week, for 45days) were block randomized into laser (n =111) and placebo (n =110) group. Laser group received LLLT (HeNe, λ =632.8nm, power-density=24mW, dosage=3.0J/point, total dosage/session=36–40J, spot-size=1cm2, 5 sessions/week) while placebo received sham treatment daily prior to radiation. OM (RTOG/EORTC Scale), oral pain (VAS), dysphagia (FIS), weight loss and CCRT break were assessed. Data were analyzed using frequencies and percentage, generalized estimating equations (GEE) and odds ratio. Results: There was significant reduction in incidence of severe OM (F =16.64, df=8876, p <0.0001) and its associated pain (F =25.06, df=8876, p <0.0001), dysphagia (F =20.17, df=8876, p <0.0001) and opioid analgesics use (p <0.0001) in laser than placebo group patients. Conclusions: LLLT decreased the incidence of CCRT induced severe OM and its associated pain, dysphagia and opioid analgesics use. [Copyright &y& Elsevier] |
| Copyright of Radiotherapy & Oncology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 82062109 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Low level laser therapy for concurrent chemoradiotherapy induced oral mucositis in head and neck cancer patients – A triple blinded randomized controlled trial – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Gautam%2C+Ajay+Prashad%22">Gautam, Ajay Prashad</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Fernandes%2C+Donald+J%2E%22">Fernandes, Donald J.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Vidyasagar%2C+Mamidipudi+S%2E%22">Vidyasagar, Mamidipudi S.</searchLink><relatesTo>2</relatesTo><i> vsagar32@yahoo.com</i><br /><searchLink fieldCode="AR" term="%22Maiya%2C+Arun+G%2E%22">Maiya, Arun G.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Vadhiraja%2C+Bejadi+M%2E%22">Vadhiraja, Bejadi M.</searchLink><relatesTo>3</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Radiotherapy+%26+Oncology%22">Radiotherapy & Oncology</searchLink>. Sep2012, Vol. 104 Issue 3, p349-354. 6p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Medical+lasers%22">Medical lasers</searchLink><br /><searchLink fieldCode="DE" term="%22Mucous+membrane+diseases%22">Mucous membrane diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Randomized+controlled+trials%22">Randomized controlled trials</searchLink><br /><searchLink fieldCode="DE" term="%22Head+%26+neck+cancer+treatment%22">Head & neck cancer treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+radiotherapy+complications%22">Cancer radiotherapy complications</searchLink><br /><searchLink fieldCode="DE" term="%22Chemotherapy+complications%22">Chemotherapy complications</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Abstract: Background and purpose: Oral mucositis (OM) is most cumbersome acute side effect of concurrent chemoradiotherapy (CCRT) for head and neck cancer (HNC). OM associated pain affects oral functions and nutrition of the patient that may result in discontinuity of treatment. Several modalities have been tried to prevent and treat OM, but none proved completely successful until date. We used prophylactic low level laser therapy (LLLT) for the prevention and treatment of CCRT induced OM. Materials and methods: In this triple blinded study, 221 HNC patients scheduled to undergo CCRT (Cisplatin (1, 22, 43day)+RT=66 Grays (2Gy/fraction), 33 fractions, 5 fractions/week, for 45days) were block randomized into laser (n =111) and placebo (n =110) group. Laser group received LLLT (HeNe, λ =632.8nm, power-density=24mW, dosage=3.0J/point, total dosage/session=36–40J, spot-size=1cm2, 5 sessions/week) while placebo received sham treatment daily prior to radiation. OM (RTOG/EORTC Scale), oral pain (VAS), dysphagia (FIS), weight loss and CCRT break were assessed. Data were analyzed using frequencies and percentage, generalized estimating equations (GEE) and odds ratio. Results: There was significant reduction in incidence of severe OM (F =16.64, df=8876, p <0.0001) and its associated pain (F =25.06, df=8876, p <0.0001), dysphagia (F =20.17, df=8876, p <0.0001) and opioid analgesics use (p <0.0001) in laser than placebo group patients. Conclusions: LLLT decreased the incidence of CCRT induced severe OM and its associated pain, dysphagia and opioid analgesics use. [Copyright &y& Elsevier] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Radiotherapy & Oncology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.radonc.2012.06.011 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 349 Subjects: – SubjectFull: Medical lasers Type: general – SubjectFull: Mucous membrane diseases Type: general – SubjectFull: Randomized controlled trials Type: general – SubjectFull: Head & neck cancer treatment Type: general – SubjectFull: Cancer radiotherapy complications Type: general – SubjectFull: Chemotherapy complications Type: general Titles: – TitleFull: Low level laser therapy for concurrent chemoradiotherapy induced oral mucositis in head and neck cancer patients – A triple blinded randomized controlled trial Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Gautam, Ajay Prashad – PersonEntity: Name: NameFull: Fernandes, Donald J. – PersonEntity: Name: NameFull: Vidyasagar, Mamidipudi S. – PersonEntity: Name: NameFull: Maiya, Arun G. – PersonEntity: Name: NameFull: Vadhiraja, Bejadi M. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2012 Type: published Y: 2012 Identifiers: – Type: issn-print Value: 01678140 Numbering: – Type: volume Value: 104 – Type: issue Value: 3 Titles: – TitleFull: Radiotherapy & Oncology Type: main |
| ResultId | 1 |
