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Supercritical carbon dioxide anti-solvent purification of anti-oxidative compounds from Lycium barbarum fruits by using response surface methodology

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Title: Supercritical carbon dioxide anti-solvent purification of anti-oxidative compounds from Lycium barbarum fruits by using response surface methodology
Authors: Chang, Li-Pin1, Cheng, Jia-Hui1, Hsu, Shih-Lan2, Fu, Yun-Ching3, Lin, Kuo-Li1, Shieh, Chwen- Jen4, Zhou, Xi-Qun5, Chang, Chieh-Ming J.1 cmchang@dragon.nchu.edu.tw
Source: Separation & Purification Technology. Oct2012, Vol. 100, p66-73. 8p.
Subjects: Western snowberry, Supercritical carbon dioxide, Water purification, Antioxidants, Surface chemistry, Zeaxanthin
Abstract: Abstract: This study employed ultrasonic extraction, column elution fractionation and supercritical anti-solvent (SAS) recrystallization in purifying and in preparing micro-sized particles containing zeaxanthin dipalmitate (ZDP) from the Lycium barbarum fruits. Column fractionation of the ultrasonic acetone extract coupled with the SAS process of the ZDP-laden ethyl-acetate solution enhanced the amount of ZDP to 931.5mg/g in the SAS precipitates (about 64.9% recovery) compared to 72.25mg/g from the ultrasonic extract alone. A two-factor experimental design by response surface method showed that feed concentration and feed flow rate were important for SAS in obtaining the highest purity and the smallest mean size of the ZDP particles. The purest ZDP compound (98.3%) also led to the proliferation of anti-hydrogen peroxide oxidation of human adult retinal pigment epithelial cells. [Copyright &y& Elsevier]
Copyright of Separation & Purification Technology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 82685916
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PubTypeId: academicJournal
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  Data: Supercritical carbon dioxide anti-solvent purification of anti-oxidative compounds from Lycium barbarum fruits by using response surface methodology
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  Data: <searchLink fieldCode="AR" term="%22Chang%2C+Li-Pin%22">Chang, Li-Pin</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Cheng%2C+Jia-Hui%22">Cheng, Jia-Hui</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Hsu%2C+Shih-Lan%22">Hsu, Shih-Lan</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Fu%2C+Yun-Ching%22">Fu, Yun-Ching</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Lin%2C+Kuo-Li%22">Lin, Kuo-Li</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Shieh%2C+Chwen-+Jen%22">Shieh, Chwen- Jen</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Zhou%2C+Xi-Qun%22">Zhou, Xi-Qun</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Chang%2C+Chieh-Ming+J%2E%22">Chang, Chieh-Ming J.</searchLink><relatesTo>1</relatesTo><i> cmchang@dragon.nchu.edu.tw</i>
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  Data: <searchLink fieldCode="JN" term="%22Separation+%26+Purification+Technology%22">Separation & Purification Technology</searchLink>. Oct2012, Vol. 100, p66-73. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Western+snowberry%22">Western snowberry</searchLink><br /><searchLink fieldCode="DE" term="%22Supercritical+carbon+dioxide%22">Supercritical carbon dioxide</searchLink><br /><searchLink fieldCode="DE" term="%22Water+purification%22">Water purification</searchLink><br /><searchLink fieldCode="DE" term="%22Antioxidants%22">Antioxidants</searchLink><br /><searchLink fieldCode="DE" term="%22Surface+chemistry%22">Surface chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Zeaxanthin%22">Zeaxanthin</searchLink>
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  Data: Abstract: This study employed ultrasonic extraction, column elution fractionation and supercritical anti-solvent (SAS) recrystallization in purifying and in preparing micro-sized particles containing zeaxanthin dipalmitate (ZDP) from the Lycium barbarum fruits. Column fractionation of the ultrasonic acetone extract coupled with the SAS process of the ZDP-laden ethyl-acetate solution enhanced the amount of ZDP to 931.5mg/g in the SAS precipitates (about 64.9% recovery) compared to 72.25mg/g from the ultrasonic extract alone. A two-factor experimental design by response surface method showed that feed concentration and feed flow rate were important for SAS in obtaining the highest purity and the smallest mean size of the ZDP particles. The purest ZDP compound (98.3%) also led to the proliferation of anti-hydrogen peroxide oxidation of human adult retinal pigment epithelial cells. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Separation & Purification Technology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.seppur.2012.09.001
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      – Code: eng
        Text: English
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      – SubjectFull: Water purification
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      – SubjectFull: Antioxidants
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      – SubjectFull: Surface chemistry
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      – SubjectFull: Zeaxanthin
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      – TitleFull: Supercritical carbon dioxide anti-solvent purification of anti-oxidative compounds from Lycium barbarum fruits by using response surface methodology
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              Text: Oct2012
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