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Plasma functionalization of titanium surface for repulsion of blood platelets

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Title: Plasma functionalization of titanium surface for repulsion of blood platelets
Authors: Cvelbar, U.1,2 uros.cvelbar@ijs.si, Modic, M.1,2, Kovač, J.1,2, Lazović, S.1,3, Filipič, G.1, Vujošević, D.4, Junkar, I.2, Eleršič, K.1,2, Brühl, S.P.5, Canal, C.6, Belmonte, T.7, Mozetič, M.2
Source: Surface & Coatings Technology. Oct2012, Vol. 211, p200-204. 5p.
Subjects: Plasma gases, Metallic surfaces, Blood platelets, Thrombosis, Coronary restenosis, Biocompatibility, Artificial implants, Surgical stents
Abstract: Abstract: Thrombosis and restenosis are the most common problems during insertion of biocompatible implants like titanium stents into human blood, due to aggregation of platelets on their surfaces. Because of this reason, we studied the response of blood platelets to a plasma treated titanium surface. The aim was to design a functionalized surface which would repel blood platelets or prevent their adhesion. Therefore, we functionalized surfaces with low-temperature inductively coupled oxygen plasma treatment, which in the first stage cleaned the surface of titanium, and in the second promoted incorporation of oxygen functional groups as well as the growth of a titanium dioxide film. In this paper we show that oxygen atoms or oxygen containing groups play an important role in the repulsion of platelets and their deactivation. At the same time, increased surface temperature of samples either through sequential thermal deactivation in oven at 150°C or heating the surface with ion bombardment during the treatment, lowers the oxygen content and the surface repulsion for platelets. [Copyright &y& Elsevier]
Copyright of Surface & Coatings Technology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 83320186
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: <searchLink fieldCode="AR" term="%22Cvelbar%2C+U%2E%22">Cvelbar, U.</searchLink><relatesTo>1,2</relatesTo><i> uros.cvelbar@ijs.si</i><br /><searchLink fieldCode="AR" term="%22Modic%2C+M%2E%22">Modic, M.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Kovač%2C+J%2E%22">Kovač, J.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Lazović%2C+S%2E%22">Lazović, S.</searchLink><relatesTo>1,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Filipič%2C+G%2E%22">Filipič, G.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Vujošević%2C+D%2E%22">Vujošević, D.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Junkar%2C+I%2E%22">Junkar, I.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Eleršič%2C+K%2E%22">Eleršič, K.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Brühl%2C+S%2EP%2E%22">Brühl, S.P.</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Canal%2C+C%2E%22">Canal, C.</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Belmonte%2C+T%2E%22">Belmonte, T.</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22Mozetič%2C+M%2E%22">Mozetič, M.</searchLink><relatesTo>2</relatesTo>
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  Data: <searchLink fieldCode="DE" term="%22Plasma+gases%22">Plasma gases</searchLink><br /><searchLink fieldCode="DE" term="%22Metallic+surfaces%22">Metallic surfaces</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+platelets%22">Blood platelets</searchLink><br /><searchLink fieldCode="DE" term="%22Thrombosis%22">Thrombosis</searchLink><br /><searchLink fieldCode="DE" term="%22Coronary+restenosis%22">Coronary restenosis</searchLink><br /><searchLink fieldCode="DE" term="%22Biocompatibility%22">Biocompatibility</searchLink><br /><searchLink fieldCode="DE" term="%22Artificial+implants%22">Artificial implants</searchLink><br /><searchLink fieldCode="DE" term="%22Surgical+stents%22">Surgical stents</searchLink>
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  Data: Abstract: Thrombosis and restenosis are the most common problems during insertion of biocompatible implants like titanium stents into human blood, due to aggregation of platelets on their surfaces. Because of this reason, we studied the response of blood platelets to a plasma treated titanium surface. The aim was to design a functionalized surface which would repel blood platelets or prevent their adhesion. Therefore, we functionalized surfaces with low-temperature inductively coupled oxygen plasma treatment, which in the first stage cleaned the surface of titanium, and in the second promoted incorporation of oxygen functional groups as well as the growth of a titanium dioxide film. In this paper we show that oxygen atoms or oxygen containing groups play an important role in the repulsion of platelets and their deactivation. At the same time, increased surface temperature of samples either through sequential thermal deactivation in oven at 150°C or heating the surface with ion bombardment during the treatment, lowers the oxygen content and the surface repulsion for platelets. [Copyright &y& Elsevier]
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  Data: <i>Copyright of Surface & Coatings Technology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.surfcoat.2012.01.017
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      – Code: eng
        Text: English
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        PageCount: 5
        StartPage: 200
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      – SubjectFull: Plasma gases
        Type: general
      – SubjectFull: Metallic surfaces
        Type: general
      – SubjectFull: Blood platelets
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      – SubjectFull: Thrombosis
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      – SubjectFull: Artificial implants
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              Text: Oct2012
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