Bibliographic Details
| Title: |
The multixenobiotic defense mechanism in mussels is induced by substrates and non-substrates: implications for a general stress response |
| Authors: |
Eufemia, N. A., Epel, D. |
| Source: |
Marine Environmental Research. Jul/Dec1998, Vol. 46 Issue 1-5, p401. 0p. |
| Subjects: |
Mussels, Xenobiotics |
| Abstract: |
A multixenobiotic defense mechanism similar to the p-glycoprotein multidrug transporter has been identified and characterized in several marine invertebrates. Its suggested role is protection from xenobiotics, both natural and anthropogenic. To assess whether MXR functions as a defense mechanism against environmental toxins, studies were undertaken to determine the inducibility of the transporter by environmental toxins. Both MXR substrates (including the pesticide chlorthal) and non-substrates (including Arochlor 1254) appeared to induce MXR activity and protein titer in the gill tissues of the mussel Mytilus californianus. Mussels exposed for 3 days to subacute concentrations ofthese compounds showed increased ability to extrude a dye substrate from the cells and exhibited a stronger band at 170 kDa on a Western blot relative to animals exposed to clean seawater. These results suggest that in mussels, MXR induction may be part of a general cellularstress response to organic toxins. [ABSTRACT FROM AUTHOR] |
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| Database: |
Engineering Source |
