The multixenobiotic defense mechanism in mussels is induced by substrates and non-substrates: implications for a general stress response
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| Title: | The multixenobiotic defense mechanism in mussels is induced by substrates and non-substrates: implications for a general stress response |
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| Authors: | Eufemia, N. A., Epel, D. |
| Source: | Marine Environmental Research. Jul/Dec1998, Vol. 46 Issue 1-5, p401. 0p. |
| Subjects: | Mussels, Xenobiotics |
| Abstract: | A multixenobiotic defense mechanism similar to the p-glycoprotein multidrug transporter has been identified and characterized in several marine invertebrates. Its suggested role is protection from xenobiotics, both natural and anthropogenic. To assess whether MXR functions as a defense mechanism against environmental toxins, studies were undertaken to determine the inducibility of the transporter by environmental toxins. Both MXR substrates (including the pesticide chlorthal) and non-substrates (including Arochlor 1254) appeared to induce MXR activity and protein titer in the gill tissues of the mussel Mytilus californianus. Mussels exposed for 3 days to subacute concentrations ofthese compounds showed increased ability to extrude a dye substrate from the cells and exhibited a stronger band at 170 kDa on a Western blot relative to animals exposed to clean seawater. These results suggest that in mussels, MXR induction may be part of a general cellularstress response to organic toxins. [ABSTRACT FROM AUTHOR] |
| Copyright of Marine Environmental Research is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 8338946 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The multixenobiotic defense mechanism in mussels is induced by substrates and non-substrates: implications for a general stress response – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Eufemia%2C+N%2E+A%2E%22">Eufemia, N. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Epel%2C+D%2E%22">Epel, D.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Marine+Environmental+Research%22">Marine Environmental Research</searchLink>. Jul/Dec1998, Vol. 46 Issue 1-5, p401. 0p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Mussels%22">Mussels</searchLink><br /><searchLink fieldCode="DE" term="%22Xenobiotics%22">Xenobiotics</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: A multixenobiotic defense mechanism similar to the p-glycoprotein multidrug transporter has been identified and characterized in several marine invertebrates. Its suggested role is protection from xenobiotics, both natural and anthropogenic. To assess whether MXR functions as a defense mechanism against environmental toxins, studies were undertaken to determine the inducibility of the transporter by environmental toxins. Both MXR substrates (including the pesticide chlorthal) and non-substrates (including Arochlor 1254) appeared to induce MXR activity and protein titer in the gill tissues of the mussel Mytilus californianus. Mussels exposed for 3 days to subacute concentrations ofthese compounds showed increased ability to extrude a dye substrate from the cells and exhibited a stronger band at 170 kDa on a Western blot relative to animals exposed to clean seawater. These results suggest that in mussels, MXR induction may be part of a general cellularstress response to organic toxins. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Marine Environmental Research is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/S0141-1136(97)00051-2 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 0 StartPage: 401 Subjects: – SubjectFull: Mussels Type: general – SubjectFull: Xenobiotics Type: general Titles: – TitleFull: The multixenobiotic defense mechanism in mussels is induced by substrates and non-substrates: implications for a general stress response Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Eufemia, N. A. – PersonEntity: Name: NameFull: Epel, D. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul/Dec1998 Type: published Y: 1998 Identifiers: – Type: issn-print Value: 01411136 Numbering: – Type: volume Value: 46 – Type: issue Value: 1-5 Titles: – TitleFull: Marine Environmental Research Type: main |
| ResultId | 1 |
