Bibliographic Details
| Title: |
Polar photodegradation products of quinolones determined by HPLC/MS/MS |
| Authors: |
Ludwig, M., Burhenne, J., Spiteller, M. |
| Source: |
Chemosphere. Jun1999, Vol. 38 Issue 14, p1279. 0p. |
| Subjects: |
Atmospheric chemistry, High performance liquid chromatography, Mass spectrometry |
| Abstract: |
The photochemical degradation of quinolones in aqueous solution proceeds in two main steps. The first step is the degradation of the piperazine substitution forming 7-amino compounds which are more stable against photolysis than the corresponding parent compound. Further photochemical degradation down to CO2 formed intermediate polar substances. By liquid/liquid partition with chloroform/water, ion exchange chromatography and semipreparative HPLC the polar compounds could be isolated. The structures of the photolytically formed pyridone tri- and dicarboxylic acids were elucidated on the basis of HPLC/MS/MS measurement. Additionally the half-life of the main polar compound, 1-cyclopropyl-pyridone-2,3,5-tricarboxylic acid was analysed by HPLC. [ABSTRACT FROM AUTHOR] |
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| Database: |
Engineering Source |
