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Polar photodegradation products of quinolones determined by HPLC/MS/MS

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Title: Polar photodegradation products of quinolones determined by HPLC/MS/MS
Authors: Ludwig, M., Burhenne, J., Spiteller, M.
Source: Chemosphere. Jun1999, Vol. 38 Issue 14, p1279. 0p.
Subjects: Atmospheric chemistry, High performance liquid chromatography, Mass spectrometry
Abstract: The photochemical degradation of quinolones in aqueous solution proceeds in two main steps. The first step is the degradation of the piperazine substitution forming 7-amino compounds which are more stable against photolysis than the corresponding parent compound. Further photochemical degradation down to CO2 formed intermediate polar substances. By liquid/liquid partition with chloroform/water, ion exchange chromatography and semipreparative HPLC the polar compounds could be isolated. The structures of the photolytically formed pyridone tri- and dicarboxylic acids were elucidated on the basis of HPLC/MS/MS measurement. Additionally the half-life of the main polar compound, 1-cyclopropyl-pyridone-2,3,5-tricarboxylic acid was analysed by HPLC. [ABSTRACT FROM AUTHOR]
Copyright of Chemosphere is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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PubType: Academic Journal
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  Data: Polar photodegradation products of quinolones determined by HPLC/MS/MS
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  Data: <searchLink fieldCode="AR" term="%22Ludwig%2C+M%2E%22">Ludwig, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Burhenne%2C+J%2E%22">Burhenne, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Spiteller%2C+M%2E%22">Spiteller, M.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Chemosphere%22">Chemosphere</searchLink>. Jun1999, Vol. 38 Issue 14, p1279. 0p.
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  Data: The photochemical degradation of quinolones in aqueous solution proceeds in two main steps. The first step is the degradation of the piperazine substitution forming 7-amino compounds which are more stable against photolysis than the corresponding parent compound. Further photochemical degradation down to CO2 formed intermediate polar substances. By liquid/liquid partition with chloroform/water, ion exchange chromatography and semipreparative HPLC the polar compounds could be isolated. The structures of the photolytically formed pyridone tri- and dicarboxylic acids were elucidated on the basis of HPLC/MS/MS measurement. Additionally the half-life of the main polar compound, 1-cyclopropyl-pyridone-2,3,5-tricarboxylic acid was analysed by HPLC. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Chemosphere is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Text: English
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      – SubjectFull: Mass spectrometry
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      – TitleFull: Polar photodegradation products of quinolones determined by HPLC/MS/MS
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            NameFull: Burhenne, J.
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              Text: Jun1999
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