Clinically compatible MRI strategies for discriminating bound and pore water in cortical bone.
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| Title: | Clinically compatible MRI strategies for discriminating bound and pore water in cortical bone. |
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| Authors: | Horch, R. Adam1,2, Gochberg, Daniel F.2,3, Nyman, Jeffry S.4,5, Does, Mark D.1,2,3,6 |
| Source: | Magnetic Resonance in Medicine. Dec2012, Vol. 68 Issue 6, p1774-1784. 11p. |
| Abstract: | Advances in modern magnetic resonance imaging (MRI) pulse sequences have enabled clinically practical cortical bone imaging. Human cortical bone is known to contain a distribution of T1 and T2 components attributed to bound and pore water, although clinical imaging approaches have yet to discriminate bound from pore water based on their relaxation properties. Herein, two clinically compatible MRI strategies are proposed for selectively imaging either bound or pore water by utilizing differences in their T1s and T2s. The strategies are validated in a population of ex vivo human cortical bones, and estimates obtained for bound and pore water are compared to bone mechanical properties. Results show that the two MRI strategies provide good estimates of bound and pore water that correlate to bone mechanical properties. As such, the strategies for bound and pore water discrimination shown herein should provide diagnostically useful tools for assessing bone fracture risk, once applied to clinical MRI. Magn Reson Med, 2012. © 2012 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR] |
| Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 83584252 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Clinically compatible MRI strategies for discriminating bound and pore water in cortical bone. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Horch%2C+R%2E+Adam%22">Horch, R. Adam</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Gochberg%2C+Daniel+F%2E%22">Gochberg, Daniel F.</searchLink><relatesTo>2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Nyman%2C+Jeffry+S%2E%22">Nyman, Jeffry S.</searchLink><relatesTo>4,5</relatesTo><br /><searchLink fieldCode="AR" term="%22Does%2C+Mark+D%2E%22">Does, Mark D.</searchLink><relatesTo>1,2,3,6</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Dec2012, Vol. 68 Issue 6, p1774-1784. 11p. – Name: Abstract Label: Abstract Group: Ab Data: Advances in modern magnetic resonance imaging (MRI) pulse sequences have enabled clinically practical cortical bone imaging. Human cortical bone is known to contain a distribution of T1 and T2 components attributed to bound and pore water, although clinical imaging approaches have yet to discriminate bound from pore water based on their relaxation properties. Herein, two clinically compatible MRI strategies are proposed for selectively imaging either bound or pore water by utilizing differences in their T1s and T2s. The strategies are validated in a population of ex vivo human cortical bones, and estimates obtained for bound and pore water are compared to bone mechanical properties. Results show that the two MRI strategies provide good estimates of bound and pore water that correlate to bone mechanical properties. As such, the strategies for bound and pore water discrimination shown herein should provide diagnostically useful tools for assessing bone fracture risk, once applied to clinical MRI. Magn Reson Med, 2012. © 2012 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mrm.24186 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 1774 Titles: – TitleFull: Clinically compatible MRI strategies for discriminating bound and pore water in cortical bone. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Horch, R. Adam – PersonEntity: Name: NameFull: Gochberg, Daniel F. – PersonEntity: Name: NameFull: Nyman, Jeffry S. – PersonEntity: Name: NameFull: Does, Mark D. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2012 Type: published Y: 2012 Identifiers: – Type: issn-print Value: 07403194 Numbering: – Type: volume Value: 68 – Type: issue Value: 6 Titles: – TitleFull: Magnetic Resonance in Medicine Type: main |
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