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Environmental Toxicants—Induced Epigenetic Alterations and Their Reversers.

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Title: Environmental Toxicants—Induced Epigenetic Alterations and Their Reversers.
Authors: KIM, MINJU1, BAE, MINJI1, NA, HYUNKYUNG1, YANG, MIHI1 myang@sm.ac.kr
Source: Journal of Environmental Science & Health. Part C. Environmental Carcinogenesis & Ecotoxicology Reviews. Oct-Dec2012, Vol. 30 Issue 4, p323-367. 45p. 3 Diagrams.
Subjects: Poisons, Epigenetics, Endocrine disruptors, Chemoprevention, Disease susceptibility, Biomarkers
Abstract: Epigenetics has been emphasized in the postgenome era to clarify obscure health risks of environmental toxicants including endocrine disrupting chemicals (EDCs). In addition, mixed exposure in real life can modify health consequences of the toxicants. Particularly, some nutritional and dietary materials modify individual susceptibility through changes in the epigenome. Therefore, we focused on some environmental toxicants that induce epigenetic alterations, and introduced chemopreventive materials to reverse the toxicants-induced epigenetic alterations. Methodologically, we used global and specific DNA methylation as epigenetic end points and searched epigenetic modulators in food. We reviewed various epigenetic end points induced by environmental toxicants including alcohol, asbestos, nanomaterials, benzene, EDCs, metals, and ionizing radiation. The epigenetic end points can be summarized into global hypomethylation and specific hypermethylation at diverse tumor suppress genes. Exposure timing, dose, sex, or organ specificity should be considered to use the epigenetic end points as biomarkers for exposure to the epimutagenic toxicants. Particularly, neonatal exposure to the epimutagens can influence their future adult health because of characteristics of the epimutagens, which disrupt epigenetic regulation in imprinting, organogenesis, development, etc. Considering interaction between epimutagenic toxicants and their reversers in food, we suggest that multiple exposures to them can alleviate or mask epigenetic toxicity in real life. Our present review provides useful information to find new end points of environmental toxicants and to prevention from environment-related diseases. [ABSTRACT FROM PUBLISHER]
Copyright of Journal of Environmental Science & Health. Part C. Environmental Carcinogenesis & Ecotoxicology Reviews is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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  Data: Environmental Toxicants—Induced Epigenetic Alterations and Their Reversers.
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  Data: <searchLink fieldCode="DE" term="%22Poisons%22">Poisons</searchLink><br /><searchLink fieldCode="DE" term="%22Epigenetics%22">Epigenetics</searchLink><br /><searchLink fieldCode="DE" term="%22Endocrine+disruptors%22">Endocrine disruptors</searchLink><br /><searchLink fieldCode="DE" term="%22Chemoprevention%22">Chemoprevention</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+susceptibility%22">Disease susceptibility</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink>
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  Data: Epigenetics has been emphasized in the postgenome era to clarify obscure health risks of environmental toxicants including endocrine disrupting chemicals (EDCs). In addition, mixed exposure in real life can modify health consequences of the toxicants. Particularly, some nutritional and dietary materials modify individual susceptibility through changes in the epigenome. Therefore, we focused on some environmental toxicants that induce epigenetic alterations, and introduced chemopreventive materials to reverse the toxicants-induced epigenetic alterations. Methodologically, we used global and specific DNA methylation as epigenetic end points and searched epigenetic modulators in food. We reviewed various epigenetic end points induced by environmental toxicants including alcohol, asbestos, nanomaterials, benzene, EDCs, metals, and ionizing radiation. The epigenetic end points can be summarized into global hypomethylation and specific hypermethylation at diverse tumor suppress genes. Exposure timing, dose, sex, or organ specificity should be considered to use the epigenetic end points as biomarkers for exposure to the epimutagenic toxicants. Particularly, neonatal exposure to the epimutagens can influence their future adult health because of characteristics of the epimutagens, which disrupt epigenetic regulation in imprinting, organogenesis, development, etc. Considering interaction between epimutagenic toxicants and their reversers in food, we suggest that multiple exposures to them can alleviate or mask epigenetic toxicity in real life. Our present review provides useful information to find new end points of environmental toxicants and to prevention from environment-related diseases. [ABSTRACT FROM PUBLISHER]
– Name: AbstractSuppliedCopyright
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  Group: Ab
  Data: <i>Copyright of Journal of Environmental Science & Health. Part C. Environmental Carcinogenesis & Ecotoxicology Reviews is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1080/10590501.2012.731959
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        Text: English
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        Type: general
      – SubjectFull: Epigenetics
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      – SubjectFull: Endocrine disruptors
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      – SubjectFull: Chemoprevention
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      – SubjectFull: Disease susceptibility
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      – SubjectFull: Biomarkers
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      – TitleFull: Environmental Toxicants—Induced Epigenetic Alterations and Their Reversers.
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            NameFull: KIM, MINJU
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            NameFull: BAE, MINJI
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            NameFull: NA, HYUNKYUNG
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            NameFull: YANG, MIHI
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              M: 10
              Text: Oct-Dec2012
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