An Inverse Problem Approach to Recovery of In Vivo Nanoparticle Concentrations from Thermal Image Monitoring of MR-Guided Laser Induced Thermal Therapy.
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| Title: | An Inverse Problem Approach to Recovery of In Vivo Nanoparticle Concentrations from Thermal Image Monitoring of MR-Guided Laser Induced Thermal Therapy. |
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| Authors: | Fuentes, D.1 dtfuentes@mdanderson.org, Elliott, A.1, Weinberg, J.2, Shetty, A.3, Hazle, J.1, Stafford, R.1 jstafford@mdanderson.org |
| Source: | Annals of Biomedical Engineering. Jan2013, Vol. 41 Issue 1, p100-111. 12p. |
| Subjects: | Inverse problems, Nanomedicine, Thermography, Heat transfer, Medical thermometry, Magnetic resonance imaging, Constrained optimization |
| Abstract: | Quantification of local variations in the optical properties of tumor tissue introduced by the presence of gold-silica nanoparticles (NP) presents significant opportunities in monitoring and control of NP-mediated laser induced thermal therapy (LITT) procedures. Finite element methods of inverse parameter recovery constrained by a Pennes bioheat transfer model were applied to estimate the optical parameters. Magnetic resonance temperature imaging (MRTI) acquired during a NP-mediated LITT of a canine transmissible venereal tumor in brain was used in the presented statistical inverse problem formulation. The maximum likelihood (ML) value of the optical parameters illustrated a marked change in the periphery of the tumor corresponding with the expected location of NP and area of selective heating observed on MRTI. Parameter recovery information became increasingly difficult to infer in distal regions of tissue where photon fluence had been significantly attenuated. Finite element temperature predictions using the ML parameter values obtained from the solution of the inverse problem are able to reproduce the NP selective heating within 5 °C of measured MRTI estimations along selected temperature profiles. Results indicate the ML solution found is able to sufficiently reproduce the selectivity of the NP mediated laser induced heating and therefore the ML solution is likely to return useful optical parameters within the region of significant laser fluence. [ABSTRACT FROM AUTHOR] |
| Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Items | – Name: Title Label: Title Group: Ti Data: An Inverse Problem Approach to Recovery of In Vivo Nanoparticle Concentrations from Thermal Image Monitoring of MR-Guided Laser Induced Thermal Therapy. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Fuentes%2C+D%2E%22">Fuentes, D.</searchLink><relatesTo>1</relatesTo><i> dtfuentes@mdanderson.org</i><br /><searchLink fieldCode="AR" term="%22Elliott%2C+A%2E%22">Elliott, A.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Weinberg%2C+J%2E%22">Weinberg, J.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Shetty%2C+A%2E%22">Shetty, A.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Hazle%2C+J%2E%22">Hazle, J.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Stafford%2C+R%2E%22">Stafford, R.</searchLink><relatesTo>1</relatesTo><i> jstafford@mdanderson.org</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Annals+of+Biomedical+Engineering%22">Annals of Biomedical Engineering</searchLink>. Jan2013, Vol. 41 Issue 1, p100-111. 12p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Inverse+problems%22">Inverse problems</searchLink><br /><searchLink fieldCode="DE" term="%22Nanomedicine%22">Nanomedicine</searchLink><br /><searchLink fieldCode="DE" term="%22Thermography%22">Thermography</searchLink><br /><searchLink fieldCode="DE" term="%22Heat+transfer%22">Heat transfer</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+thermometry%22">Medical thermometry</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Constrained+optimization%22">Constrained optimization</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Quantification of local variations in the optical properties of tumor tissue introduced by the presence of gold-silica nanoparticles (NP) presents significant opportunities in monitoring and control of NP-mediated laser induced thermal therapy (LITT) procedures. Finite element methods of inverse parameter recovery constrained by a Pennes bioheat transfer model were applied to estimate the optical parameters. Magnetic resonance temperature imaging (MRTI) acquired during a NP-mediated LITT of a canine transmissible venereal tumor in brain was used in the presented statistical inverse problem formulation. The maximum likelihood (ML) value of the optical parameters illustrated a marked change in the periphery of the tumor corresponding with the expected location of NP and area of selective heating observed on MRTI. Parameter recovery information became increasingly difficult to infer in distal regions of tissue where photon fluence had been significantly attenuated. Finite element temperature predictions using the ML parameter values obtained from the solution of the inverse problem are able to reproduce the NP selective heating within 5 °C of measured MRTI estimations along selected temperature profiles. Results indicate the ML solution found is able to sufficiently reproduce the selectivity of the NP mediated laser induced heating and therefore the ML solution is likely to return useful optical parameters within the region of significant laser fluence. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10439-012-0638-9 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 100 Subjects: – SubjectFull: Inverse problems Type: general – SubjectFull: Nanomedicine Type: general – SubjectFull: Thermography Type: general – SubjectFull: Heat transfer Type: general – SubjectFull: Medical thermometry Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Constrained optimization Type: general Titles: – TitleFull: An Inverse Problem Approach to Recovery of In Vivo Nanoparticle Concentrations from Thermal Image Monitoring of MR-Guided Laser Induced Thermal Therapy. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Fuentes, D. – PersonEntity: Name: NameFull: Elliott, A. – PersonEntity: Name: NameFull: Weinberg, J. – PersonEntity: Name: NameFull: Shetty, A. – PersonEntity: Name: NameFull: Hazle, J. – PersonEntity: Name: NameFull: Stafford, R. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2013 Type: published Y: 2013 Identifiers: – Type: issn-print Value: 00906964 Numbering: – Type: volume Value: 41 – Type: issue Value: 1 Titles: – TitleFull: Annals of Biomedical Engineering Type: main |
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