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Measurement of 129Xe gas apparent diffusion coefficient anisotropy in an elastase-instilled rat model of emphysema.

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Title: Measurement of 129Xe gas apparent diffusion coefficient anisotropy in an elastase-instilled rat model of emphysema.
Authors: Boudreau, Mathieu1,2,3, Xu, Xiaojun1,2,4, Santyr, Giles E.1,5,6 gsantyr@imaging.robarts.ca
Source: Magnetic Resonance in Medicine. Jan2013, Vol. 69 Issue 1, p211-220. 10p.
Abstract: Hyperpolarized noble gas (3He and 129Xe) apparent diffusion coefficient (ADC) measurements have shown remarkable sensitivity to microstructural (i.e., alveolar) changes in the lung, particularly emphysema. The ADC of hyperpolarized noble gases depends strongly on the diffusion time (Δ), and 3He ADC has been shown to be anisotropic for Δ ranging from a few milliseconds down to a few hundred microseconds. In this study, the anisotropic nature of 129Xe diffusion and its dependence on Δ were investigated both numerically, in a budded cylinder model, and in vivo, in an elastase-instilled rat model of emphysema. Whole lung longitudinal ADC ( DL) and transverse ADC ( DT) were measured for Δ = 6, 50, and 100 ms at 73.5 mT, and correlated with measurements of the mean linear intercept ( Lm) obtained from lung histology. A significant increase ( P = 0.0021) in DT was measured for Δ = 6 ms between the sham (0.0021 ± 0.0005 cm2/s) and elastase-instilled (0.005 ± 0.001 cm2/s) cohorts, and a strong correlation was measured between DT (Δ = 6 ms) and Lm, with a Pearson's correlation coefficient of 0.90. This study confirms that 129Xe DT increases correlate with alveolar space enlargement due to elastase instillation in rats. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]
Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Measurement of <superscript>129</superscript>Xe gas apparent diffusion coefficient anisotropy in an elastase-instilled rat model of emphysema.
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  Data: <searchLink fieldCode="AR" term="%22Boudreau%2C+Mathieu%22">Boudreau, Mathieu</searchLink><relatesTo>1,2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Xu%2C+Xiaojun%22">Xu, Xiaojun</searchLink><relatesTo>1,2,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Santyr%2C+Giles+E%2E%22">Santyr, Giles E.</searchLink><relatesTo>1,5,6</relatesTo><i> gsantyr@imaging.robarts.ca</i>
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  Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Jan2013, Vol. 69 Issue 1, p211-220. 10p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Hyperpolarized noble gas (3He and 129Xe) apparent diffusion coefficient (ADC) measurements have shown remarkable sensitivity to microstructural (i.e., alveolar) changes in the lung, particularly emphysema. The ADC of hyperpolarized noble gases depends strongly on the diffusion time (Δ), and 3He ADC has been shown to be anisotropic for Δ ranging from a few milliseconds down to a few hundred microseconds. In this study, the anisotropic nature of 129Xe diffusion and its dependence on Δ were investigated both numerically, in a budded cylinder model, and in vivo, in an elastase-instilled rat model of emphysema. Whole lung longitudinal ADC ( DL) and transverse ADC ( DT) were measured for Δ = 6, 50, and 100 ms at 73.5 mT, and correlated with measurements of the mean linear intercept ( Lm) obtained from lung histology. A significant increase ( P = 0.0021) in DT was measured for Δ = 6 ms between the sham (0.0021 ± 0.0005 cm2/s) and elastase-instilled (0.005 ± 0.001 cm2/s) cohorts, and a strong correlation was measured between DT (Δ = 6 ms) and Lm, with a Pearson's correlation coefficient of 0.90. This study confirms that 129Xe DT increases correlate with alveolar space enlargement due to elastase instillation in rats. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – TitleFull: Measurement of 129Xe gas apparent diffusion coefficient anisotropy in an elastase-instilled rat model of emphysema.
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