Biotransformation of codeine to 14-OH-codeine derivatives by Rhizobium radiobacter R89-1
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| Title: | Biotransformation of codeine to 14-OH-codeine derivatives by Rhizobium radiobacter R89-1 |
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| Authors: | Kyslíková, Eva1, Babiak, Peter1,2, Štěpánek, Václav1 stepanek@biomed.cas.cz, Zahradník, Jiří1, Palyzová, Andrea1, Marešová, Helena1, Valešová, Renáta1, Hájíček, Josef2, Kyslík, Pavel1 |
| Source: | Journal of Molecular Catalysis B: Enzymatic. Mar2013, Vol. 87, p1-5. 5p. |
| Subjects: | Biotransformation (Metabolism), Codeine derivatives, Agrobacterium radiobacter, Enzymes, Gram-negative bacteria, Opium poppy, Ribosomal RNA, Morphine |
| Abstract: | Abstract: A Gram-negative bacterium transforming codeine 1a to 14-hydroxycodeine 1c was isolated from the sample of composted wastes of Papaver somniferum deposited in a factory producing poppy seed. Based on 16S ribosomal RNA gene phylogeny, biochemical and morphological properties, the strain was designated as Rhizobium radiobacter R89-1. The bacterium is able to transform 1a into four C-14-hydroxy derivatives of codeine. When used as a whole-cell catalyst, 100% conversion was achieved at concentration of 1a up to 6.0g/L to 14-hydroxycodeine 1c as a single product. Biohydroxylation of codeine to C-14-hydroxy derivatives, a high tolerance of the strain to 1a and activity with morphine 2a make the biocatalyst promising for pharmaceutical applications. [Copyright &y& Elsevier] |
| Copyright of Journal of Molecular Catalysis B: Enzymatic is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 84598393 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Biotransformation of codeine to 14-OH-codeine derivatives by Rhizobium radiobacter R89-1 – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kyslíková%2C+Eva%22">Kyslíková, Eva</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Babiak%2C+Peter%22">Babiak, Peter</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Štěpánek%2C+Václav%22">Štěpánek, Václav</searchLink><relatesTo>1</relatesTo><i> stepanek@biomed.cas.cz</i><br /><searchLink fieldCode="AR" term="%22Zahradník%2C+Jiří%22">Zahradník, Jiří</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Palyzová%2C+Andrea%22">Palyzová, Andrea</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Marešová%2C+Helena%22">Marešová, Helena</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Valešová%2C+Renáta%22">Valešová, Renáta</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Hájíček%2C+Josef%22">Hájíček, Josef</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Kyslík%2C+Pavel%22">Kyslík, Pavel</searchLink><relatesTo>1</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Molecular+Catalysis+B%3A+Enzymatic%22">Journal of Molecular Catalysis B: Enzymatic</searchLink>. Mar2013, Vol. 87, p1-5. 5p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Biotransformation+%28Metabolism%29%22">Biotransformation (Metabolism)</searchLink><br /><searchLink fieldCode="DE" term="%22Codeine+derivatives%22">Codeine derivatives</searchLink><br /><searchLink fieldCode="DE" term="%22Agrobacterium+radiobacter%22">Agrobacterium radiobacter</searchLink><br /><searchLink fieldCode="DE" term="%22Enzymes%22">Enzymes</searchLink><br /><searchLink fieldCode="DE" term="%22Gram-negative+bacteria%22">Gram-negative bacteria</searchLink><br /><searchLink fieldCode="DE" term="%22Opium+poppy%22">Opium poppy</searchLink><br /><searchLink fieldCode="DE" term="%22Ribosomal+RNA%22">Ribosomal RNA</searchLink><br /><searchLink fieldCode="DE" term="%22Morphine%22">Morphine</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Abstract: A Gram-negative bacterium transforming codeine 1a to 14-hydroxycodeine 1c was isolated from the sample of composted wastes of Papaver somniferum deposited in a factory producing poppy seed. Based on 16S ribosomal RNA gene phylogeny, biochemical and morphological properties, the strain was designated as Rhizobium radiobacter R89-1. The bacterium is able to transform 1a into four C-14-hydroxy derivatives of codeine. When used as a whole-cell catalyst, 100% conversion was achieved at concentration of 1a up to 6.0g/L to 14-hydroxycodeine 1c as a single product. Biohydroxylation of codeine to C-14-hydroxy derivatives, a high tolerance of the strain to 1a and activity with morphine 2a make the biocatalyst promising for pharmaceutical applications. [Copyright &y& Elsevier] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Molecular Catalysis B: Enzymatic is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.molcatb.2012.10.004 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 1 Subjects: – SubjectFull: Biotransformation (Metabolism) Type: general – SubjectFull: Codeine derivatives Type: general – SubjectFull: Agrobacterium radiobacter Type: general – SubjectFull: Enzymes Type: general – SubjectFull: Gram-negative bacteria Type: general – SubjectFull: Opium poppy Type: general – SubjectFull: Ribosomal RNA Type: general – SubjectFull: Morphine Type: general Titles: – TitleFull: Biotransformation of codeine to 14-OH-codeine derivatives by Rhizobium radiobacter R89-1 Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kyslíková, Eva – PersonEntity: Name: NameFull: Babiak, Peter – PersonEntity: Name: NameFull: Štěpánek, Václav – PersonEntity: Name: NameFull: Zahradník, Jiří – PersonEntity: Name: NameFull: Palyzová, Andrea – PersonEntity: Name: NameFull: Marešová, Helena – PersonEntity: Name: NameFull: Valešová, Renáta – PersonEntity: Name: NameFull: Hájíček, Josef – PersonEntity: Name: NameFull: Kyslík, Pavel IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2013 Type: published Y: 2013 Identifiers: – Type: issn-print Value: 13811177 Numbering: – Type: volume Value: 87 Titles: – TitleFull: Journal of Molecular Catalysis B: Enzymatic Type: main |
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