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Vitexin-2-O-xyloside, raphasatin and (−)-epigallocatechin-3-gallate synergistically affect cell growth and apoptosis of colon cancer cells

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Title: Vitexin-2-O-xyloside, raphasatin and (−)-epigallocatechin-3-gallate synergistically affect cell growth and apoptosis of colon cancer cells
Authors: Papi, Alessio1, Farabegoli, Fulvia2, Iori, Renato3, Orlandi, Marina1, De Nicola, Gina R.3, Bagatta, Manuela3, Angelino, Donato4, Gennari, Lorenzo4, Ninfali, Paolino4
Source: Food Chemistry. Jun2013, Vol. 138 Issue 2/3, p1521-1530. 10p.
Subjects: Xyloside, Epigallocatechin gallate, Cell growth, Apoptosis, Colon cancer, Cancer cells, Isothiocyanates
Abstract: Abstract: Cytotoxic effects of the combination of the food components vitexin-2-O-xyloside (X), raphasatin (4-methylsulphanyl-3-butenyl isothiocyanates; G) and (–)-epigallocatechin-3-gallate (E) were investigated in colon (LoVo and CaCo-2) and breast (MDA-MB-231 and MCF-7) cancer cells. Breast cancer cells were more resistant than colon cells to X, G and E inhibition. On the contrary, marked synergistic effects among X, G and E on cell growth were found in both colon cancer cells. Further analysis revealed a G0/G1 arrest of the phase cell progression and apoptosis, linked to modulation of Bax, Bcl2, caspase-9 and poly(ADP-ribose) polymerase as well as Reactive Oxygen Species (ROS) generation in both colon cancer cells, whereas apoptosis and ROS were not significantly detected in normal human lymphocytes. We conclude that the X, G and E mixture might act by mitochondrial pathway activation of apoptosis, possibly elicited by ROS and the mixture may be effective in the chemoprevention of colon cancer. [Copyright &y& Elsevier]
Copyright of Food Chemistry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Vitexin-2-O-xyloside, raphasatin and (−)-epigallocatechin-3-gallate synergistically affect cell growth and apoptosis of colon cancer cells
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  Data: <searchLink fieldCode="AR" term="%22Papi%2C+Alessio%22">Papi, Alessio</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Farabegoli%2C+Fulvia%22">Farabegoli, Fulvia</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Iori%2C+Renato%22">Iori, Renato</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Orlandi%2C+Marina%22">Orlandi, Marina</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22De+Nicola%2C+Gina+R%2E%22">De Nicola, Gina R.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Bagatta%2C+Manuela%22">Bagatta, Manuela</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Angelino%2C+Donato%22">Angelino, Donato</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Gennari%2C+Lorenzo%22">Gennari, Lorenzo</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Ninfali%2C+Paolino%22">Ninfali, Paolino</searchLink><relatesTo>4</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Food+Chemistry%22">Food Chemistry</searchLink>. Jun2013, Vol. 138 Issue 2/3, p1521-1530. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Xyloside%22">Xyloside</searchLink><br /><searchLink fieldCode="DE" term="%22Epigallocatechin+gallate%22">Epigallocatechin gallate</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+growth%22">Cell growth</searchLink><br /><searchLink fieldCode="DE" term="%22Apoptosis%22">Apoptosis</searchLink><br /><searchLink fieldCode="DE" term="%22Colon+cancer%22">Colon cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+cells%22">Cancer cells</searchLink><br /><searchLink fieldCode="DE" term="%22Isothiocyanates%22">Isothiocyanates</searchLink>
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  Data: Abstract: Cytotoxic effects of the combination of the food components vitexin-2-O-xyloside (X), raphasatin (4-methylsulphanyl-3-butenyl isothiocyanates; G) and (–)-epigallocatechin-3-gallate (E) were investigated in colon (LoVo and CaCo-2) and breast (MDA-MB-231 and MCF-7) cancer cells. Breast cancer cells were more resistant than colon cells to X, G and E inhibition. On the contrary, marked synergistic effects among X, G and E on cell growth were found in both colon cancer cells. Further analysis revealed a G0/G1 arrest of the phase cell progression and apoptosis, linked to modulation of Bax, Bcl2, caspase-9 and poly(ADP-ribose) polymerase as well as Reactive Oxygen Species (ROS) generation in both colon cancer cells, whereas apoptosis and ROS were not significantly detected in normal human lymphocytes. We conclude that the X, G and E mixture might act by mitochondrial pathway activation of apoptosis, possibly elicited by ROS and the mixture may be effective in the chemoprevention of colon cancer. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Food Chemistry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.foodchem.2012.11.112
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      – Code: eng
        Text: English
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        PageCount: 10
        StartPage: 1521
    Subjects:
      – SubjectFull: Xyloside
        Type: general
      – SubjectFull: Epigallocatechin gallate
        Type: general
      – SubjectFull: Cell growth
        Type: general
      – SubjectFull: Apoptosis
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      – SubjectFull: Colon cancer
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      – SubjectFull: Cancer cells
        Type: general
      – SubjectFull: Isothiocyanates
        Type: general
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      – TitleFull: Vitexin-2-O-xyloside, raphasatin and (−)-epigallocatechin-3-gallate synergistically affect cell growth and apoptosis of colon cancer cells
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              M: 06
              Text: Jun2013
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              Y: 2013
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