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LC–MS analysis, anticancer, antioxidant and antimalarial activities of Cynodon dactylon L. extracts

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Title: LC–MS analysis, anticancer, antioxidant and antimalarial activities of Cynodon dactylon L. extracts
Authors: Khlifi, Daycem1,2, Hayouni, El Akrem3, Valentin, Alexis4, Cazaux, Sylvie1, Moukarzel, Béatrice4, Hamdi, Moktar2, Bouajila, Jalloul1 jalloul.bouajila@univ-tlse3.fr
Source: Industrial Crops & Products. Feb2013, Vol. 45, p240-247. 8p.
Subjects: Liquid chromatography-mass spectrometry, Antineoplastic agents, Antioxidants, Antimalarials, Bermuda grass, Therapeutic use of plant extracts
Abstract: Abstract: Extracts (petroleum ether, dichloromethane, acetone, methanol/water (3/1) and water) from Cynodon dactylon L. were obtained by sequential method. The chemical composition of phenolics (6.9–57.41g gallic acid equivalents/kg of dry mass), tannins (2.49–12.32g catechin equivalent/kg of dry mass), anthocyanins (0–5.98g cyanidin equivalent/kg of dry mass) and flavonoids (0–5.02g quercetin equivalent/kg of dry mass) was evaluated. The extracts were evaluated for their antioxidant (DPPH and ABTS assays), antimalarial (Plasmodium falciparum) and anticancer (MCF-7) activities; the strongest activities were obtained by the water extract (IC50 =57.21±1.47mg/L), the acetonic extract (IC50 =38mg/L) and the petroleum ether extract (IC50 =39mg/L), respectively. The results indicate a good correlations between anthocyanins quantity and the antimalarial activity (R 2 =0.79) and also to anticancer activity (R 2 =0.78). The LC–MS analysis of the extracts having the good activities anticancer and antimalarial, has revealed the presence of seven anthocyanins (delphinidin-3-O-acetylglucoside, petunidin-3-O-caffeoylglucoside-5-O-glucoside, petunidin-3-O-coumarylglucoside-5-O-glucoside, malvidin-3-O-monoglucoside, delphinidin-3-O-acetylglucoside-pyruvic acid, petunidin-3-O-acetylglucoside-5-O-glucoside and cyanidin-3,5-O-diglucoside), identified for the first time in this plant. [Copyright &y& Elsevier]
Copyright of Industrial Crops & Products is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
An: 85614449
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PubTypeId: academicJournal
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  Data: LC–MS analysis, anticancer, antioxidant and antimalarial activities of Cynodon dactylon L. extracts
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  Data: <searchLink fieldCode="AR" term="%22Khlifi%2C+Daycem%22">Khlifi, Daycem</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Hayouni%2C+El+Akrem%22">Hayouni, El Akrem</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Valentin%2C+Alexis%22">Valentin, Alexis</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Cazaux%2C+Sylvie%22">Cazaux, Sylvie</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Moukarzel%2C+Béatrice%22">Moukarzel, Béatrice</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Hamdi%2C+Moktar%22">Hamdi, Moktar</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Bouajila%2C+Jalloul%22">Bouajila, Jalloul</searchLink><relatesTo>1</relatesTo><i> jalloul.bouajila@univ-tlse3.fr</i>
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  Data: <searchLink fieldCode="JN" term="%22Industrial+Crops+%26+Products%22">Industrial Crops & Products</searchLink>. Feb2013, Vol. 45, p240-247. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Liquid+chromatography-mass+spectrometry%22">Liquid chromatography-mass spectrometry</searchLink><br /><searchLink fieldCode="DE" term="%22Antineoplastic+agents%22">Antineoplastic agents</searchLink><br /><searchLink fieldCode="DE" term="%22Antioxidants%22">Antioxidants</searchLink><br /><searchLink fieldCode="DE" term="%22Antimalarials%22">Antimalarials</searchLink><br /><searchLink fieldCode="DE" term="%22Bermuda+grass%22">Bermuda grass</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutic+use+of+plant+extracts%22">Therapeutic use of plant extracts</searchLink>
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  Data: Abstract: Extracts (petroleum ether, dichloromethane, acetone, methanol/water (3/1) and water) from Cynodon dactylon L. were obtained by sequential method. The chemical composition of phenolics (6.9–57.41g gallic acid equivalents/kg of dry mass), tannins (2.49–12.32g catechin equivalent/kg of dry mass), anthocyanins (0–5.98g cyanidin equivalent/kg of dry mass) and flavonoids (0–5.02g quercetin equivalent/kg of dry mass) was evaluated. The extracts were evaluated for their antioxidant (DPPH and ABTS assays), antimalarial (Plasmodium falciparum) and anticancer (MCF-7) activities; the strongest activities were obtained by the water extract (IC50 =57.21±1.47mg/L), the acetonic extract (IC50 =38mg/L) and the petroleum ether extract (IC50 =39mg/L), respectively. The results indicate a good correlations between anthocyanins quantity and the antimalarial activity (R 2 =0.79) and also to anticancer activity (R 2 =0.78). The LC–MS analysis of the extracts having the good activities anticancer and antimalarial, has revealed the presence of seven anthocyanins (delphinidin-3-O-acetylglucoside, petunidin-3-O-caffeoylglucoside-5-O-glucoside, petunidin-3-O-coumarylglucoside-5-O-glucoside, malvidin-3-O-monoglucoside, delphinidin-3-O-acetylglucoside-pyruvic acid, petunidin-3-O-acetylglucoside-5-O-glucoside and cyanidin-3,5-O-diglucoside), identified for the first time in this plant. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Industrial Crops & Products is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.indcrop.2012.12.030
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      – Code: eng
        Text: English
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        PageCount: 8
        StartPage: 240
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      – SubjectFull: Liquid chromatography-mass spectrometry
        Type: general
      – SubjectFull: Antineoplastic agents
        Type: general
      – SubjectFull: Antioxidants
        Type: general
      – SubjectFull: Antimalarials
        Type: general
      – SubjectFull: Bermuda grass
        Type: general
      – SubjectFull: Therapeutic use of plant extracts
        Type: general
    Titles:
      – TitleFull: LC–MS analysis, anticancer, antioxidant and antimalarial activities of Cynodon dactylon L. extracts
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            NameFull: Khlifi, Daycem
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              M: 02
              Text: Feb2013
              Type: published
              Y: 2013
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              Value: 45
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