View in EDS

Patterns of Disease Recurrence Following Treatment of Oropharyngeal Cancer With Intensity Modulated Radiation Therapy

Saved in:
Bibliographic Details
Title: Patterns of Disease Recurrence Following Treatment of Oropharyngeal Cancer With Intensity Modulated Radiation Therapy
Authors: Garden, Adam S.1 agarden@mdanderson.org, Dong, Lei2, Morrison, William H.1, Stugis, Erich M.3,4, Glisson, Bonnie S.5, Frank, Steven J.1, Beadle, Beth M.1, Gunn, Gary B.1, Schwartz, David L.6, Kies, Merill S.1,5, Weber, Randal S.3, Ang, K. Kian1, Rosenthal, David I.1
Source: International Journal of Radiation Oncology, Biology, Physics. Mar2013, Vol. 85 Issue 4, p941-947. 7p.
Subjects: Oropharyngeal cancer, Cancer radiotherapy, Cancer relapse, Cancer treatment, Squamous cell carcinoma, Health outcome assessment, Cohort analysis, Retrospective studies
Abstract: Purpose: To report mature results of a large cohort of patients diagnosed with squamous cell carcinoma of the oropharynx who were treated with intensity modulated radiation therapy (IMRT). Methods and Materials: The database of patients irradiated at The University of Texas, M.D. Anderson Cancer Center was searched for patients diagnosed with oropharyngeal cancer and treated with IMRT between 2000 and 2007. A retrospective review of outcome data was performed. Results: The cohort consisted of 776 patients. One hundred fifty-nine patients (21%) were current smokers, 279 (36%) former smokers, and 337 (43%) never smokers. T and N categories and American Joint Committee on Cancer group stages were distributed as follows: T1/x, 288 (37%); T2, 288 (37%); T3, 113 (15%); T4, 87 (11%); N0, 88(12%); N1/x, 140 (18%); N2a, 101 (13%); N2b, 269 (35%); N2c, 122 (16%); and N3, 56 (7%); stage I, 18(2%); stage II, 40(5%); stage III, 150(19%); and stage IV, 568(74%). Seventy-one patients (10%) presented with nodes in level IV. Median follow-up was 54 months. The 5-year overall survival, locoregional control, and overall recurrence-free survival rates were 84%, 90%, and 82%, respectively. Primary site recurrence developed in 7% of patients, and neck recurrence with primary site control in 3%. We could only identify 12 patients (2%) who had locoregional recurrence outside the high-dose target volumes. Poorer survival rates were observed in current smokers, patients with larger primary (T) tumors and lower neck disease. Conclusions: Patients with oropharyngeal cancer treated with IMRT have excellent disease control. Locoregional recurrence was uncommon, and most often occurred in the high dose volumes. Parotid sparing was accomplished in nearly all patients without compromising tumor coverage. [Copyright &y& Elsevier]
Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 85874710
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Patterns of Disease Recurrence Following Treatment of Oropharyngeal Cancer With Intensity Modulated Radiation Therapy
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Garden%2C+Adam+S%2E%22">Garden, Adam S.</searchLink><relatesTo>1</relatesTo><i> agarden@mdanderson.org</i><br /><searchLink fieldCode="AR" term="%22Dong%2C+Lei%22">Dong, Lei</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Morrison%2C+William+H%2E%22">Morrison, William H.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Stugis%2C+Erich+M%2E%22">Stugis, Erich M.</searchLink><relatesTo>3,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Glisson%2C+Bonnie+S%2E%22">Glisson, Bonnie S.</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Frank%2C+Steven+J%2E%22">Frank, Steven J.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Beadle%2C+Beth+M%2E%22">Beadle, Beth M.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Gunn%2C+Gary+B%2E%22">Gunn, Gary B.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Schwartz%2C+David+L%2E%22">Schwartz, David L.</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Kies%2C+Merill+S%2E%22">Kies, Merill S.</searchLink><relatesTo>1,5</relatesTo><br /><searchLink fieldCode="AR" term="%22Weber%2C+Randal+S%2E%22">Weber, Randal S.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Ang%2C+K%2E+Kian%22">Ang, K. Kian</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Rosenthal%2C+David+I%2E%22">Rosenthal, David I.</searchLink><relatesTo>1</relatesTo>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Radiation+Oncology%2C+Biology%2C+Physics%22">International Journal of Radiation Oncology, Biology, Physics</searchLink>. Mar2013, Vol. 85 Issue 4, p941-947. 7p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Oropharyngeal+cancer%22">Oropharyngeal cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+radiotherapy%22">Cancer radiotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+relapse%22">Cancer relapse</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+treatment%22">Cancer treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Squamous+cell+carcinoma%22">Squamous cell carcinoma</searchLink><br /><searchLink fieldCode="DE" term="%22Health+outcome+assessment%22">Health outcome assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Cohort+analysis%22">Cohort analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Retrospective+studies%22">Retrospective studies</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: To report mature results of a large cohort of patients diagnosed with squamous cell carcinoma of the oropharynx who were treated with intensity modulated radiation therapy (IMRT). Methods and Materials: The database of patients irradiated at The University of Texas, M.D. Anderson Cancer Center was searched for patients diagnosed with oropharyngeal cancer and treated with IMRT between 2000 and 2007. A retrospective review of outcome data was performed. Results: The cohort consisted of 776 patients. One hundred fifty-nine patients (21%) were current smokers, 279 (36%) former smokers, and 337 (43%) never smokers. T and N categories and American Joint Committee on Cancer group stages were distributed as follows: T1/x, 288 (37%); T2, 288 (37%); T3, 113 (15%); T4, 87 (11%); N0, 88(12%); N1/x, 140 (18%); N2a, 101 (13%); N2b, 269 (35%); N2c, 122 (16%); and N3, 56 (7%); stage I, 18(2%); stage II, 40(5%); stage III, 150(19%); and stage IV, 568(74%). Seventy-one patients (10%) presented with nodes in level IV. Median follow-up was 54 months. The 5-year overall survival, locoregional control, and overall recurrence-free survival rates were 84%, 90%, and 82%, respectively. Primary site recurrence developed in 7% of patients, and neck recurrence with primary site control in 3%. We could only identify 12 patients (2%) who had locoregional recurrence outside the high-dose target volumes. Poorer survival rates were observed in current smokers, patients with larger primary (T) tumors and lower neck disease. Conclusions: Patients with oropharyngeal cancer treated with IMRT have excellent disease control. Locoregional recurrence was uncommon, and most often occurred in the high dose volumes. Parotid sparing was accomplished in nearly all patients without compromising tumor coverage. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=85874710
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.ijrobp.2012.08.004
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 941
    Subjects:
      – SubjectFull: Oropharyngeal cancer
        Type: general
      – SubjectFull: Cancer radiotherapy
        Type: general
      – SubjectFull: Cancer relapse
        Type: general
      – SubjectFull: Cancer treatment
        Type: general
      – SubjectFull: Squamous cell carcinoma
        Type: general
      – SubjectFull: Health outcome assessment
        Type: general
      – SubjectFull: Cohort analysis
        Type: general
      – SubjectFull: Retrospective studies
        Type: general
    Titles:
      – TitleFull: Patterns of Disease Recurrence Following Treatment of Oropharyngeal Cancer With Intensity Modulated Radiation Therapy
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Garden, Adam S.
      – PersonEntity:
          Name:
            NameFull: Dong, Lei
      – PersonEntity:
          Name:
            NameFull: Morrison, William H.
      – PersonEntity:
          Name:
            NameFull: Stugis, Erich M.
      – PersonEntity:
          Name:
            NameFull: Glisson, Bonnie S.
      – PersonEntity:
          Name:
            NameFull: Frank, Steven J.
      – PersonEntity:
          Name:
            NameFull: Beadle, Beth M.
      – PersonEntity:
          Name:
            NameFull: Gunn, Gary B.
      – PersonEntity:
          Name:
            NameFull: Schwartz, David L.
      – PersonEntity:
          Name:
            NameFull: Kies, Merill S.
      – PersonEntity:
          Name:
            NameFull: Weber, Randal S.
      – PersonEntity:
          Name:
            NameFull: Ang, K. Kian
      – PersonEntity:
          Name:
            NameFull: Rosenthal, David I.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 15
              M: 03
              Text: Mar2013
              Type: published
              Y: 2013
          Identifiers:
            – Type: issn-print
              Value: 03603016
          Numbering:
            – Type: volume
              Value: 85
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: International Journal of Radiation Oncology, Biology, Physics
              Type: main
ResultId 1