An injectable cell penetrable nano-polyplex hydrogel for localized siRNA delivery
Saved in:
| Title: | An injectable cell penetrable nano-polyplex hydrogel for localized siRNA delivery |
|---|---|
| Authors: | Kim, Young-Min1,2, Park, Mi-Ran1, Song, Soo-Chang1,2 scsong@kist.re.kr |
| Source: | Biomaterials. Jun2013, Vol. 34 Issue 18, p4493-4500. 8p. |
| Subjects: | Hydrogels, Non-coding RNA, Polyphosphazenes, Gene silencing, Cell-penetrating peptides, Protamines |
| Abstract: | Abstract: An approach for application of cell penetration to selective small interference RNA (siRNA) localized delivery system, cell penetrable nano-polyplex assembled hydrogel system, is presented. The cell penetrable nano-polyplex assembled hydrogelisprepared by protamine conjugation to poly(organophos-phazene) and inducement of nano-polyplexes with siRNAs. After an injection of cell penetrable nano-polyplex solution into the body, it turns into a gel due to thermosensitivity of poly(organo-phosphazene). The gel maintains up to 4 weeks and the released 30 nm-sized nano-polyplexes from the gel induces highly effective siRNA delivery due to cell penetration. Accordingly, the new system shows a high gene silencing efficiency on only the target site in long-term with a single injection. [Copyright &y& Elsevier] |
| Copyright of Biomaterials is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
|---|---|
| Header | DbId: egs DbLabel: Engineering Source An: 86464672 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: An injectable cell penetrable nano-polyplex hydrogel for localized siRNA delivery – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kim%2C+Young-Min%22">Kim, Young-Min</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Park%2C+Mi-Ran%22">Park, Mi-Ran</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Song%2C+Soo-Chang%22">Song, Soo-Chang</searchLink><relatesTo>1,2</relatesTo><i> scsong@kist.re.kr</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Biomaterials%22">Biomaterials</searchLink>. Jun2013, Vol. 34 Issue 18, p4493-4500. 8p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Hydrogels%22">Hydrogels</searchLink><br /><searchLink fieldCode="DE" term="%22Non-coding+RNA%22">Non-coding RNA</searchLink><br /><searchLink fieldCode="DE" term="%22Polyphosphazenes%22">Polyphosphazenes</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+silencing%22">Gene silencing</searchLink><br /><searchLink fieldCode="DE" term="%22Cell-penetrating+peptides%22">Cell-penetrating peptides</searchLink><br /><searchLink fieldCode="DE" term="%22Protamines%22">Protamines</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Abstract: An approach for application of cell penetration to selective small interference RNA (siRNA) localized delivery system, cell penetrable nano-polyplex assembled hydrogel system, is presented. The cell penetrable nano-polyplex assembled hydrogelisprepared by protamine conjugation to poly(organophos-phazene) and inducement of nano-polyplexes with siRNAs. After an injection of cell penetrable nano-polyplex solution into the body, it turns into a gel due to thermosensitivity of poly(organo-phosphazene). The gel maintains up to 4 weeks and the released 30 nm-sized nano-polyplexes from the gel induces highly effective siRNA delivery due to cell penetration. Accordingly, the new system shows a high gene silencing efficiency on only the target site in long-term with a single injection. [Copyright &y& Elsevier] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Biomaterials is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=86464672 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.biomaterials.2013.02.050 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 4493 Subjects: – SubjectFull: Hydrogels Type: general – SubjectFull: Non-coding RNA Type: general – SubjectFull: Polyphosphazenes Type: general – SubjectFull: Gene silencing Type: general – SubjectFull: Cell-penetrating peptides Type: general – SubjectFull: Protamines Type: general Titles: – TitleFull: An injectable cell penetrable nano-polyplex hydrogel for localized siRNA delivery Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kim, Young-Min – PersonEntity: Name: NameFull: Park, Mi-Ran – PersonEntity: Name: NameFull: Song, Soo-Chang IsPartOfRelationships: – BibEntity: Dates: – D: 10 M: 06 Text: Jun2013 Type: published Y: 2013 Identifiers: – Type: issn-print Value: 01429612 Numbering: – Type: volume Value: 34 – Type: issue Value: 18 Titles: – TitleFull: Biomaterials Type: main |
| ResultId | 1 |
