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Molecular genetics and subjective well-being.

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Title: Molecular genetics and subjective well-being.
Authors: Rietveld, Cornelius A.1, Cesarini, David2,3, Benjamin, Daniel J.4, Koellinger, Philipp D.1, De Neve, Jan-Emmanuel5,6, Tiemeier, Henning7, Johannesson, Magnus8, Magnusson, Patrik K. E.9, Pedersen, Nancy L.9, Krueger, Robert F.10, Bartels, Meike11,12 m.bartels@vu.nl
Source: Proceedings of the National Academy of Sciences of the United States of America. 6/11/2013, Vol. 110 Issue 24, p9692-9697. 6p.
Subjects: Subjective well-being (Psychology), Molecular genetics, Genetic polymorphisms, Heritability, Social sciences
Abstract: Subjective well-being (SWB) is a major topic of research across the social sciences. Twin and family studies have found that genetic factors may account for as much as 30-40% of the variance in SWB. Here, we study genetic contributions to SWB in a pooled sample of ≈11,500 unrelated, comprehensively-genotyped Swedish and Dutch individuals. We apply a recently developed method to estimate "common narrow heritability": the fraction of variance in SWB that can be explained by the cumulative additive effects of genetic polymorphisms that are common in the population. Our estimates are 5-10% for single-question survey measures of SWB, and 12-18% after correction for measurement error in the SWB measures. Our results suggest guarded optimism about the prospects of using genetic data in SWB research because, although the common narrow heritability is not large, the polymorphisms that contribute to it could feasibly be discovered with a sufficiently large sample of individuals. [ABSTRACT FROM AUTHOR]
Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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PubType: Academic Journal
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  Data: Molecular genetics and subjective well-being.
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  Data: <searchLink fieldCode="AR" term="%22Rietveld%2C+Cornelius+A%2E%22">Rietveld, Cornelius A.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Cesarini%2C+David%22">Cesarini, David</searchLink><relatesTo>2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Benjamin%2C+Daniel+J%2E%22">Benjamin, Daniel J.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Koellinger%2C+Philipp+D%2E%22">Koellinger, Philipp D.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22De+Neve%2C+Jan-Emmanuel%22">De Neve, Jan-Emmanuel</searchLink><relatesTo>5,6</relatesTo><br /><searchLink fieldCode="AR" term="%22Tiemeier%2C+Henning%22">Tiemeier, Henning</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22Johannesson%2C+Magnus%22">Johannesson, Magnus</searchLink><relatesTo>8</relatesTo><br /><searchLink fieldCode="AR" term="%22Magnusson%2C+Patrik+K%2E+E%2E%22">Magnusson, Patrik K. E.</searchLink><relatesTo>9</relatesTo><br /><searchLink fieldCode="AR" term="%22Pedersen%2C+Nancy+L%2E%22">Pedersen, Nancy L.</searchLink><relatesTo>9</relatesTo><br /><searchLink fieldCode="AR" term="%22Krueger%2C+Robert+F%2E%22">Krueger, Robert F.</searchLink><relatesTo>10</relatesTo><br /><searchLink fieldCode="AR" term="%22Bartels%2C+Meike%22">Bartels, Meike</searchLink><relatesTo>11,12</relatesTo><i> m.bartels@vu.nl</i>
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  Data: <searchLink fieldCode="DE" term="%22Subjective+well-being+%28Psychology%29%22">Subjective well-being (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+genetics%22">Molecular genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+polymorphisms%22">Genetic polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22Heritability%22">Heritability</searchLink><br /><searchLink fieldCode="DE" term="%22Social+sciences%22">Social sciences</searchLink>
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  Data: Subjective well-being (SWB) is a major topic of research across the social sciences. Twin and family studies have found that genetic factors may account for as much as 30-40% of the variance in SWB. Here, we study genetic contributions to SWB in a pooled sample of ≈11,500 unrelated, comprehensively-genotyped Swedish and Dutch individuals. We apply a recently developed method to estimate "common narrow heritability": the fraction of variance in SWB that can be explained by the cumulative additive effects of genetic polymorphisms that are common in the population. Our estimates are 5-10% for single-question survey measures of SWB, and 12-18% after correction for measurement error in the SWB measures. Our results suggest guarded optimism about the prospects of using genetic data in SWB research because, although the common narrow heritability is not large, the polymorphisms that contribute to it could feasibly be discovered with a sufficiently large sample of individuals. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1073/pnas.1222171110
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      – Code: eng
        Text: English
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      – SubjectFull: Subjective well-being (Psychology)
        Type: general
      – SubjectFull: Molecular genetics
        Type: general
      – SubjectFull: Genetic polymorphisms
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      – SubjectFull: Heritability
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              Text: 6/11/2013
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