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Generalized multiparticle Mie modeling of light scattering by cells.

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Title: Generalized multiparticle Mie modeling of light scattering by cells.
Authors: Wang, Meng1, Cao, Min1, Guo, ZhiRui2, Gu, Ning1 guning@seu.edu.cn
Source: Chinese Science Bulletin. Jul2013, Vol. 58 Issue 21, p2663-2666. 4p.
Subjects: Multiparticle spectrometers, Mie scattering, Light scattering, Nanoparticles, Cancer cells, Biosensors
Abstract: The development of nanobiology requires a fundamental understanding of the interaction features between light and cells as well as cells containing nanoparticles. In this study, the generalized multiparticleMie (GMM) theory was employed to calculate the scattering properties of cells under refractive index matching conditions. The angular distribution of scattered light is statistically averaged to obtain a good fit for the experimental results. Based on a simplified cell model, the variabilities between the scattered light pattern of normal cells and that of cancerous cells were examined. The results indicate that the small angle scattering is sensitive to the organelle distribution, which could be applied in the diagnostics of cancerous cells. Finally, the effects of cellular uptake of nanoparticles on the scattering pattern was also investigated. [ABSTRACT FROM AUTHOR]
Copyright of Chinese Science Bulletin is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: <searchLink fieldCode="AR" term="%22Wang%2C+Meng%22">Wang, Meng</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Cao%2C+Min%22">Cao, Min</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Guo%2C+ZhiRui%22">Guo, ZhiRui</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Gu%2C+Ning%22">Gu, Ning</searchLink><relatesTo>1</relatesTo><i> guning@seu.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Chinese+Science+Bulletin%22">Chinese Science Bulletin</searchLink>. Jul2013, Vol. 58 Issue 21, p2663-2666. 4p.
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  Data: <searchLink fieldCode="DE" term="%22Multiparticle+spectrometers%22">Multiparticle spectrometers</searchLink><br /><searchLink fieldCode="DE" term="%22Mie+scattering%22">Mie scattering</searchLink><br /><searchLink fieldCode="DE" term="%22Light+scattering%22">Light scattering</searchLink><br /><searchLink fieldCode="DE" term="%22Nanoparticles%22">Nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+cells%22">Cancer cells</searchLink><br /><searchLink fieldCode="DE" term="%22Biosensors%22">Biosensors</searchLink>
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  Data: The development of nanobiology requires a fundamental understanding of the interaction features between light and cells as well as cells containing nanoparticles. In this study, the generalized multiparticleMie (GMM) theory was employed to calculate the scattering properties of cells under refractive index matching conditions. The angular distribution of scattered light is statistically averaged to obtain a good fit for the experimental results. Based on a simplified cell model, the variabilities between the scattered light pattern of normal cells and that of cancerous cells were examined. The results indicate that the small angle scattering is sensitive to the organelle distribution, which could be applied in the diagnostics of cancerous cells. Finally, the effects of cellular uptake of nanoparticles on the scattering pattern was also investigated. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Chinese Science Bulletin is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s11434-013-5719-0
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        Text: English
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        Type: general
      – SubjectFull: Mie scattering
        Type: general
      – SubjectFull: Light scattering
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      – SubjectFull: Nanoparticles
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      – SubjectFull: Cancer cells
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      – SubjectFull: Biosensors
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      – TitleFull: Generalized multiparticle Mie modeling of light scattering by cells.
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              M: 07
              Text: Jul2013
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              Y: 2013
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