Development of Preparative Chiral Separations Using an Intelligent Chiral Resolution System.
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| Title: | Development of Preparative Chiral Separations Using an Intelligent Chiral Resolution System. |
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| Authors: | Kennedy, JosephH.1 (AUTHOR) kennedy-joseph-h@lilly.com, Scott Sharp, V.1 (AUTHOR), Williams, JeffreyD.1 (AUTHOR) |
| Source: | Journal of Liquid Chromatography & Related Technologies. 2/15/2003, Vol. 26 Issue 4, p529-543. 15p. 1 Chart. |
| Subjects: | Chirality, Enantiomers, Chromatographic analysis |
| Abstract: | Chiral preparative chromatography is a technology increasingly used in the pharmaceutical industry to deliver enantiomerically pure drug candidates. A strategy for rapid screening of conditions on polysaccharide chiral stationary phases (CSPs) has been developed with an emphasis on preparative applications. Sample solubility is a major limiting factor in preparative chromatography. Most reported analytical chiral separations on polysaccharide CSPs are with eluent systems consisting of mainly hexane and small amounts of alcohol as a modifier. The intelligent chiral resolution system (ICRS) was developed to emphasize polar solvents as the first choice for eluent systems. Examples of this approach, and details on the screening procedure are presented. Using the system, chiral preparative procedures can be developed for most compounds in approximately 3 hours. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Liquid Chromatography & Related Technologies is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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