Impact of hemodynamics on lumen boundary displacements in abdominal aortic aneurysms by means of dynamic computed tomography and computational fluid dynamics.
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| Title: | Impact of hemodynamics on lumen boundary displacements in abdominal aortic aneurysms by means of dynamic computed tomography and computational fluid dynamics. |
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| Authors: | Piccinelli, Marina1, Vergara, Christian2, Antiga, Luca3, Forzenigo, Laura4, Biondetti, Pietro4, Domanin, Maurizio maurizio.domanin@unimi.it |
| Source: | Biomechanics & Modeling in Mechanobiology. Nov2013, Vol. 12 Issue 6, p1263-1276. 14p. |
| Subjects: | Aortic diseases, Vascular diseases, Hemodynamics, Heart beat measurement, Aortic aneurysms, Computed tomography, Shearing force |
| Abstract: | The aim of the present work is to quantitatively assess the three-dimensional distributions of the displacements experienced during the cardiac cycle by the luminal boundary of abdominal aortic aneurysm (AAA) and to correlate them with the local bulk hemodynamics. Ten patients were acquired by means of time resolved computed tomography, and each patient-specific vascular morphology was reconstructed for all available time frames. The AAA lumen boundary motion was tracked, and the lumen boundary displacements (LBD) computed for each time frame. The intra-aneurysm hemodynamic quantities, specifically wall shear stress (WSS), were evaluated with computational fluid dynamics simulations. Co-localization of LBD and WSS distributions was evaluated by means of Pearson correlation coefficient. A clear anisotropic distribution of LBD was evidenced in both space and time; a combination of AAA lumen boundary inward- and outward-directed motions was assessed. A co-localization between largest outward LBD and high WSS was demonstrated supporting the hypothesis of a mechanistic relationship between anisotropic displacement and hemodynamic forces related to the impingement of the blood on the lumen boundary. The presence of anisotropic displacement of the AAA lumen boundary and their link to hemodynamic forces have been assessed, highlighting a new possible role for hemodynamics in the study of AAA progression. [ABSTRACT FROM AUTHOR] |
| Copyright of Biomechanics & Modeling in Mechanobiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 91279433 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Impact of hemodynamics on lumen boundary displacements in abdominal aortic aneurysms by means of dynamic computed tomography and computational fluid dynamics. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Piccinelli%2C+Marina%22">Piccinelli, Marina</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Vergara%2C+Christian%22">Vergara, Christian</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Antiga%2C+Luca%22">Antiga, Luca</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Forzenigo%2C+Laura%22">Forzenigo, Laura</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Biondetti%2C+Pietro%22">Biondetti, Pietro</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Domanin%2C+Maurizio%22">Domanin, Maurizio</searchLink><i> maurizio.domanin@unimi.it</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Biomechanics+%26+Modeling+in+Mechanobiology%22">Biomechanics & Modeling in Mechanobiology</searchLink>. Nov2013, Vol. 12 Issue 6, p1263-1276. 14p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Aortic+diseases%22">Aortic diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Vascular+diseases%22">Vascular diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Hemodynamics%22">Hemodynamics</searchLink><br /><searchLink fieldCode="DE" term="%22Heart+beat+measurement%22">Heart beat measurement</searchLink><br /><searchLink fieldCode="DE" term="%22Aortic+aneurysms%22">Aortic aneurysms</searchLink><br /><searchLink fieldCode="DE" term="%22Computed+tomography%22">Computed tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Shearing+force%22">Shearing force</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The aim of the present work is to quantitatively assess the three-dimensional distributions of the displacements experienced during the cardiac cycle by the luminal boundary of abdominal aortic aneurysm (AAA) and to correlate them with the local bulk hemodynamics. Ten patients were acquired by means of time resolved computed tomography, and each patient-specific vascular morphology was reconstructed for all available time frames. The AAA lumen boundary motion was tracked, and the lumen boundary displacements (LBD) computed for each time frame. The intra-aneurysm hemodynamic quantities, specifically wall shear stress (WSS), were evaluated with computational fluid dynamics simulations. Co-localization of LBD and WSS distributions was evaluated by means of Pearson correlation coefficient. A clear anisotropic distribution of LBD was evidenced in both space and time; a combination of AAA lumen boundary inward- and outward-directed motions was assessed. A co-localization between largest outward LBD and high WSS was demonstrated supporting the hypothesis of a mechanistic relationship between anisotropic displacement and hemodynamic forces related to the impingement of the blood on the lumen boundary. The presence of anisotropic displacement of the AAA lumen boundary and their link to hemodynamic forces have been assessed, highlighting a new possible role for hemodynamics in the study of AAA progression. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Biomechanics & Modeling in Mechanobiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10237-013-0480-5 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 14 StartPage: 1263 Subjects: – SubjectFull: Aortic diseases Type: general – SubjectFull: Vascular diseases Type: general – SubjectFull: Hemodynamics Type: general – SubjectFull: Heart beat measurement Type: general – SubjectFull: Aortic aneurysms Type: general – SubjectFull: Computed tomography Type: general – SubjectFull: Shearing force Type: general Titles: – TitleFull: Impact of hemodynamics on lumen boundary displacements in abdominal aortic aneurysms by means of dynamic computed tomography and computational fluid dynamics. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Piccinelli, Marina – PersonEntity: Name: NameFull: Vergara, Christian – PersonEntity: Name: NameFull: Antiga, Luca – PersonEntity: Name: NameFull: Forzenigo, Laura – PersonEntity: Name: NameFull: Biondetti, Pietro – PersonEntity: Name: NameFull: Domanin, Maurizio IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2013 Type: published Y: 2013 Identifiers: – Type: issn-print Value: 16177959 Numbering: – Type: volume Value: 12 – Type: issue Value: 6 Titles: – TitleFull: Biomechanics & Modeling in Mechanobiology Type: main |
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