Small-angle X-ray scattering and light scattering study of hybrid nanoparticles composed of thermoresponsive triblock copolymer F127 and thermoresponsive statistical polyoxazolines with hydrophobic moieties.
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| Title: | Small-angle X-ray scattering and light scattering study of hybrid nanoparticles composed of thermoresponsive triblock copolymer F127 and thermoresponsive statistical polyoxazolines with hydrophobic moieties. |
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| Authors: | Bogomolova, Anna, Hruby, Martin, Panek, Jiri, Rabyk, Maria, Turner, Stuart, Bals, Sara, Steinhart, Milos, Zhigunov, Alexander, Sedlacek, Ondrej, Stepanek, Petr, Filippov, Sergey K. |
| Source: | Journal of Applied Crystallography. Dec2013, Vol. 46 Issue 6, p1690-1698. 9p. |
| Subjects: | Small-angle X-ray scattering, Light scattering, Nanoparticles, Block copolymers, Oxazoline, Surface active agents, Radioisotopes |
| Abstract: | A combination of new thermoresponsive statistical polyoxazolines, poly[(2-butyl-2-oxazoline)- stat-(2-isopropyl-2-oxazoline)] [pBuOx- co-piPrOx], with different hydrophobic moieties and F127 surfactant as a template system for the creation of thermosensitive nanoparticles for radionuclide delivery has recently been tested [Pánek, Filippov, Hrubý, Rabyk, Bogomolova, Kučka & Stěpánek (2012). Macromol. Rapid Commun. 33, 1683-1689]. It was shown that the presence of the thermosensitive F127 triblock copolymer in solution reduces nanoparticle size and polydispersity. This article focuses on a determination of the internal structure and solution properties of the nanoparticles in the temperature range from 288 to 312 K. Here, it is demonstrated that below the cloud point temperature (CPT) the polyoxazolines and F127 form complexes that co-exist in solution with single F127 molecules and large aggregates. When the temperature is raised above the CPT, nanoparticles composed of polyoxazolines and F127 are predominant in solution. These nanoparticles could be described by a spherical shell model. It was found that the molar weight and hydrophobicity of the polymer do not influence the size of the outer radius and only slightly change the inner radius of the nanoparticles. At the same time, molar weight and hydrophobicity did affect the process of nanoparticle formation. In conclusion, poly(2-oxazoline) molecules are fully incorporated inside of F127 micelles, and this result is very promising for the successful application of such systems in radionuclide delivery. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Applied Crystallography is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 92016801 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Small-angle X-ray scattering and light scattering study of hybrid nanoparticles composed of thermoresponsive triblock copolymer F127 and thermoresponsive statistical polyoxazolines with hydrophobic moieties. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Bogomolova%2C+Anna%22">Bogomolova, Anna</searchLink><br /><searchLink fieldCode="AR" term="%22Hruby%2C+Martin%22">Hruby, Martin</searchLink><br /><searchLink fieldCode="AR" term="%22Panek%2C+Jiri%22">Panek, Jiri</searchLink><br /><searchLink fieldCode="AR" term="%22Rabyk%2C+Maria%22">Rabyk, Maria</searchLink><br /><searchLink fieldCode="AR" term="%22Turner%2C+Stuart%22">Turner, Stuart</searchLink><br /><searchLink fieldCode="AR" term="%22Bals%2C+Sara%22">Bals, Sara</searchLink><br /><searchLink fieldCode="AR" term="%22Steinhart%2C+Milos%22">Steinhart, Milos</searchLink><br /><searchLink fieldCode="AR" term="%22Zhigunov%2C+Alexander%22">Zhigunov, Alexander</searchLink><br /><searchLink fieldCode="AR" term="%22Sedlacek%2C+Ondrej%22">Sedlacek, Ondrej</searchLink><br /><searchLink fieldCode="AR" term="%22Stepanek%2C+Petr%22">Stepanek, Petr</searchLink><br /><searchLink fieldCode="AR" term="%22Filippov%2C+Sergey+K%2E%22">Filippov, Sergey K.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Applied+Crystallography%22">Journal of Applied Crystallography</searchLink>. Dec2013, Vol. 46 Issue 6, p1690-1698. 9p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Small-angle+X-ray+scattering%22">Small-angle X-ray scattering</searchLink><br /><searchLink fieldCode="DE" term="%22Light+scattering%22">Light scattering</searchLink><br /><searchLink fieldCode="DE" term="%22Nanoparticles%22">Nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Block+copolymers%22">Block copolymers</searchLink><br /><searchLink fieldCode="DE" term="%22Oxazoline%22">Oxazoline</searchLink><br /><searchLink fieldCode="DE" term="%22Surface+active+agents%22">Surface active agents</searchLink><br /><searchLink fieldCode="DE" term="%22Radioisotopes%22">Radioisotopes</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: A combination of new thermoresponsive statistical polyoxazolines, poly[(2-butyl-2-oxazoline)- stat-(2-isopropyl-2-oxazoline)] [pBuOx- co-piPrOx], with different hydrophobic moieties and F127 surfactant as a template system for the creation of thermosensitive nanoparticles for radionuclide delivery has recently been tested [Pánek, Filippov, Hrubý, Rabyk, Bogomolova, Kučka & Stěpánek (2012). Macromol. Rapid Commun. 33, 1683-1689]. It was shown that the presence of the thermosensitive F127 triblock copolymer in solution reduces nanoparticle size and polydispersity. This article focuses on a determination of the internal structure and solution properties of the nanoparticles in the temperature range from 288 to 312 K. Here, it is demonstrated that below the cloud point temperature (CPT) the polyoxazolines and F127 form complexes that co-exist in solution with single F127 molecules and large aggregates. When the temperature is raised above the CPT, nanoparticles composed of polyoxazolines and F127 are predominant in solution. These nanoparticles could be described by a spherical shell model. It was found that the molar weight and hydrophobicity of the polymer do not influence the size of the outer radius and only slightly change the inner radius of the nanoparticles. At the same time, molar weight and hydrophobicity did affect the process of nanoparticle formation. In conclusion, poly(2-oxazoline) molecules are fully incorporated inside of F127 micelles, and this result is very promising for the successful application of such systems in radionuclide delivery. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Applied Crystallography is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1107/S0021889813027064 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 1690 Subjects: – SubjectFull: Small-angle X-ray scattering Type: general – SubjectFull: Light scattering Type: general – SubjectFull: Nanoparticles Type: general – SubjectFull: Block copolymers Type: general – SubjectFull: Oxazoline Type: general – SubjectFull: Surface active agents Type: general – SubjectFull: Radioisotopes Type: general Titles: – TitleFull: Small-angle X-ray scattering and light scattering study of hybrid nanoparticles composed of thermoresponsive triblock copolymer F127 and thermoresponsive statistical polyoxazolines with hydrophobic moieties. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bogomolova, Anna – PersonEntity: Name: NameFull: Hruby, Martin – PersonEntity: Name: NameFull: Panek, Jiri – PersonEntity: Name: NameFull: Rabyk, Maria – PersonEntity: Name: NameFull: Turner, Stuart – PersonEntity: Name: NameFull: Bals, Sara – PersonEntity: Name: NameFull: Steinhart, Milos – PersonEntity: Name: NameFull: Zhigunov, Alexander – PersonEntity: Name: NameFull: Sedlacek, Ondrej – PersonEntity: Name: NameFull: Stepanek, Petr – PersonEntity: Name: NameFull: Filippov, Sergey K. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2013 Type: published Y: 2013 Identifiers: – Type: issn-print Value: 00218898 Numbering: – Type: volume Value: 46 – Type: issue Value: 6 Titles: – TitleFull: Journal of Applied Crystallography Type: main |
| ResultId | 1 |
