A high-resolution peak fractionation approach for streamlined screening of nuclear-factor-E2-related factor-2 activators in Salvia miltiorrhiza.
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| Title: | A high-resolution peak fractionation approach for streamlined screening of nuclear-factor-E2-related factor-2 activators in Salvia miltiorrhiza. |
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| Authors: | Zhang, Hui1, Luo, Li-Ping1, Song, Hui-Peng1, Hao, Hai-Ping1, Zhou, Ping1, Qi, Lian-Wen1, Li, Ping1 liping2004@126.com, Chen, Jun1 chenj2002@gmail.com |
| Source: | Journal of Chromatography A. Jan2014, Vol. 1326, p47-55. 9p. |
| Subjects: | Polymer fractionation, NF-kappa B, Salvia, Streamlines (Fluids), Bioactive compounds, High performance liquid chromatography, Diterpenes |
| Abstract: | Highlights: [•] A universal HRPF strategy was developed for discovery of bioactive compounds. [•] This strategy realized high-purity peak fraction preparation in one HPLC run. [•] HRPF combined with a luciferase reporter gene assay to screen Nrf2 activators. [•] 20 diterpene quinones were screened out and unambiguously identified. [•] 16 compounds were reported to possess novel Nrf2 activation effect. [Copyright &y& Elsevier] |
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| Database: | Engineering Source |
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