View in EDS PDF Full Text

Effect of physiological temperature on the mechanical properties and network structure of biodegradable poly(propylene fumarate)-based networks.

Saved in:
Bibliographic Details
Title: Effect of physiological temperature on the mechanical properties and network structure of biodegradable poly(propylene fumarate)-based networks.
Authors: Timmer, Mark D., Horch, R. Adam, Ambrose, Catherine G., Mikos, Antonios G.
Source: Journal of Biomaterials Science -- Polymer Edition. Apr2003, Vol. 14 Issue 4, p369-382. 14p.
Subjects: Biopolymers, Physiological effects of heat
Abstract: Poly(propylene fumarate) (PPF)-based networks have exhibited increases in mechanical properties during their initial stages of degradation. This study was designed to investigate whether physiological temperatures are the source of this reinforcing behavior by influencing the formation of additional crosslinks within the network. Utilizing a model PPF network formed with the crosslinking agent poly(propylene fumarate)-diacrylate (PPF-DA), cylindrical specimens were stored in an inert environment and conditioned at -20 and 37°C while their mechanical properties and network structure were monitored over a six week period. The PPF/PPF-DA specimens exposed to physiological temperatures showed an increase in compressive modulus from 1674 ± 88 to 2059 ± 75 MPa. The double bond conversion improved as well, from 64 ± 1 to 70 ± 1%, indicating that crosslinks were being formed in the network. The additional reactivity occurred exclusively with unreacted fumarate bonds. PPF/PPF-DA networks stored at -20°C showed no changes in mechanical properties; however, they increased when subsequently conditioned at 37°C. The results were used to explain that PPF-based networks undergo a biphasic degradation behavior due to the competing hydrolytic degradation and thermal induced crosslinking. In addition, heat treating the networks at higher temperatures can be utilized as a means to further reinforce PPF-based materials. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Biomaterials Science -- Polymer Edition is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 9412344
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Effect of physiological temperature on the mechanical properties and network structure of biodegradable poly(propylene fumarate)-based networks.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Timmer%2C+Mark+D%2E%22">Timmer, Mark D.</searchLink><br /><searchLink fieldCode="AR" term="%22Horch%2C+R%2E+Adam%22">Horch, R. Adam</searchLink><br /><searchLink fieldCode="AR" term="%22Ambrose%2C+Catherine+G%2E%22">Ambrose, Catherine G.</searchLink><br /><searchLink fieldCode="AR" term="%22Mikos%2C+Antonios+G%2E%22">Mikos, Antonios G.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Journal+of+Biomaterials+Science+--+Polymer+Edition%22">Journal of Biomaterials Science -- Polymer Edition</searchLink>. Apr2003, Vol. 14 Issue 4, p369-382. 14p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Biopolymers%22">Biopolymers</searchLink><br /><searchLink fieldCode="DE" term="%22Physiological+effects+of+heat%22">Physiological effects of heat</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Poly(propylene fumarate) (PPF)-based networks have exhibited increases in mechanical properties during their initial stages of degradation. This study was designed to investigate whether physiological temperatures are the source of this reinforcing behavior by influencing the formation of additional crosslinks within the network. Utilizing a model PPF network formed with the crosslinking agent poly(propylene fumarate)-diacrylate (PPF-DA), cylindrical specimens were stored in an inert environment and conditioned at -20 and 37°C while their mechanical properties and network structure were monitored over a six week period. The PPF/PPF-DA specimens exposed to physiological temperatures showed an increase in compressive modulus from 1674 ± 88 to 2059 ± 75 MPa. The double bond conversion improved as well, from 64 ± 1 to 70 ± 1%, indicating that crosslinks were being formed in the network. The additional reactivity occurred exclusively with unreacted fumarate bonds. PPF/PPF-DA networks stored at -20°C showed no changes in mechanical properties; however, they increased when subsequently conditioned at 37°C. The results were used to explain that PPF-based networks undergo a biphasic degradation behavior due to the competing hydrolytic degradation and thermal induced crosslinking. In addition, heat treating the networks at higher temperatures can be utilized as a means to further reinforce PPF-based materials. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Biomaterials Science -- Polymer Edition is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=9412344
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1163/156856203321478874
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 14
        StartPage: 369
    Subjects:
      – SubjectFull: Biopolymers
        Type: general
      – SubjectFull: Physiological effects of heat
        Type: general
    Titles:
      – TitleFull: Effect of physiological temperature on the mechanical properties and network structure of biodegradable poly(propylene fumarate)-based networks.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Timmer, Mark D.
      – PersonEntity:
          Name:
            NameFull: Horch, R. Adam
      – PersonEntity:
          Name:
            NameFull: Ambrose, Catherine G.
      – PersonEntity:
          Name:
            NameFull: Mikos, Antonios G.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 04
              Text: Apr2003
              Type: published
              Y: 2003
          Identifiers:
            – Type: issn-print
              Value: 09205063
          Numbering:
            – Type: volume
              Value: 14
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: Journal of Biomaterials Science -- Polymer Edition
              Type: main
ResultId 1