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Concurrent spatial mapping of the elasticity of heterogeneous soft materials via a polymer-based microfluidic device.

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Title: Concurrent spatial mapping of the elasticity of heterogeneous soft materials via a polymer-based microfluidic device.
Authors: Gu, Wenting1, Cheng, Peng1, Palmer, Xavier-Lewis2, Hao, Zhili1 zlhao@odu.edu
Source: Journal of Micromechanics & Microengineering. Oct2013, Vol. 23 Issue 10, p105007-105022. 16p.
Subjects: Microfluidic devices, Elasticity, Polymer research, Strength of materials, Residual stresses, Fracture mechanics
Abstract: In this paper, built upon a polymer-based microfluidic device, a novel experimental technique called concurrent spatial mapping (CSM) is presented for measuring the spatially-varying elasticity of heterogeneous soft materials. Comprised of a single compliant polymer microstructure and a set of electrolyte-enabled distributed resistive transducers, this device is capable of detecting continuous distributed loads. In this experimental technique, a rigid probe is employed to press a material specimen against the device with precisely controlled displacements, and consequently the spatially-varying elasticity of the specimen translates to continuous distributed loads acting on the device, where continuous distributed loads give rise to continuous deflection of the polymer microstructure and register as discrete resistance changes at the locations of the distributed transducers. Performance characterization is first conducted on the device as a control experiment. Then, CSM is implemented on several heterogeneous and homogeneous polydimethylsiloxane specimens, as well as a rabbit tissue specimen. The associated data analysis is performed on the measured data for extracting the spatially-varying load-deflection relations of these specimens. In conjunction with its dimensions, the extracted spatially-varying load-deflection relations of a specimen result in its spatially-varying elasticity by the related theoretical formula. For the first time, this paper demonstrates the feasibility of using a single polymer-based microfluidic device to concurrently map out the spatially-varying elasticity of heterogeneous soft materials. As a result, CSM will pave the way for efficiently examining biological tissues and cell-seeded engineering scaffolds, while without excluding the interaction among neighboring compositions in such materials. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Micromechanics & Microengineering is the property of IOP Publishing and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
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  Data: Concurrent spatial mapping of the elasticity of heterogeneous soft materials via a polymer-based microfluidic device.
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  Data: <searchLink fieldCode="AR" term="%22Gu%2C+Wenting%22">Gu, Wenting</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Cheng%2C+Peng%22">Cheng, Peng</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Palmer%2C+Xavier-Lewis%22">Palmer, Xavier-Lewis</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Hao%2C+Zhili%22">Hao, Zhili</searchLink><relatesTo>1</relatesTo><i> zlhao@odu.edu</i>
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  Data: <searchLink fieldCode="DE" term="%22Microfluidic+devices%22">Microfluidic devices</searchLink><br /><searchLink fieldCode="DE" term="%22Elasticity%22">Elasticity</searchLink><br /><searchLink fieldCode="DE" term="%22Polymer+research%22">Polymer research</searchLink><br /><searchLink fieldCode="DE" term="%22Strength+of+materials%22">Strength of materials</searchLink><br /><searchLink fieldCode="DE" term="%22Residual+stresses%22">Residual stresses</searchLink><br /><searchLink fieldCode="DE" term="%22Fracture+mechanics%22">Fracture mechanics</searchLink>
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  Data: In this paper, built upon a polymer-based microfluidic device, a novel experimental technique called concurrent spatial mapping (CSM) is presented for measuring the spatially-varying elasticity of heterogeneous soft materials. Comprised of a single compliant polymer microstructure and a set of electrolyte-enabled distributed resistive transducers, this device is capable of detecting continuous distributed loads. In this experimental technique, a rigid probe is employed to press a material specimen against the device with precisely controlled displacements, and consequently the spatially-varying elasticity of the specimen translates to continuous distributed loads acting on the device, where continuous distributed loads give rise to continuous deflection of the polymer microstructure and register as discrete resistance changes at the locations of the distributed transducers. Performance characterization is first conducted on the device as a control experiment. Then, CSM is implemented on several heterogeneous and homogeneous polydimethylsiloxane specimens, as well as a rabbit tissue specimen. The associated data analysis is performed on the measured data for extracting the spatially-varying load-deflection relations of these specimens. In conjunction with its dimensions, the extracted spatially-varying load-deflection relations of a specimen result in its spatially-varying elasticity by the related theoretical formula. For the first time, this paper demonstrates the feasibility of using a single polymer-based microfluidic device to concurrently map out the spatially-varying elasticity of heterogeneous soft materials. As a result, CSM will pave the way for efficiently examining biological tissues and cell-seeded engineering scaffolds, while without excluding the interaction among neighboring compositions in such materials. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of Micromechanics & Microengineering is the property of IOP Publishing and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1088/0960-1317/23/10/105007
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      – SubjectFull: Elasticity
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      – SubjectFull: Polymer research
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      – SubjectFull: Strength of materials
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      – SubjectFull: Residual stresses
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              Text: Oct2013
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