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Wound healing and antibacterial activities of chondroitin sulfate- and acharan sulfate-reduced silver nanoparticles.

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Title: Wound healing and antibacterial activities of chondroitin sulfate- and acharan sulfate-reduced silver nanoparticles.
Authors: Im, A-Rang1, Kim, Jee Young1, Kim, Hyun-Seok2 kims@snu.ac.kr, Cho, Seonho2, Park, Youmie2,3 youmiep@inje.ac.kr, Kim, Yeong Shik1
Source: Nanotechnology. 10/4/2013, Vol. 24 Issue 39, p395102-395113. 12p.
Subjects: Wound healing, Chondroitin sulfates, Silver nanoparticles, Antibacterial agents, Biomedical materials, Glycosaminoglycans
Abstract: For topical applications in wound healing, silver nanoparticles (AgNPs) have attracted much attention as antibacterial agents. Herein, we describe a green-synthetic route for the production of biocompatible and crystalline AgNPs using two glycosaminoglycans, chondroitin sulfate (CS) and acharan sulfate (AS), as reducing agents. The synthetic approach avoids the use of toxic chemicals, and the yield of AgNPs formation is found to be 98.1% and 91.1% for the chondroitin sulfate-reduced silver nanoparticles (CS-AgNPs) and the acharan sulfate-reduced silver nanoparticles (AS-AgNPs), respectively. Nanoparticles with mostly spherical and amorphous shapes were observed, with an average diameter of 6.16 ± 2.26 nm for CS-AgNPs and 5.79 ± 3.10 nm for AS-AgNPs. Images of the CS-AgNPs obtained from atomic force microscopy revealed the self-assembled structure of CS was similar to a densely packed woven mat with AgNPs sprinkled on the CS. These nanoparticles were stable under cell culture conditions without any noticeable aggregation. An approximately 128-fold enhancement of the antibacterial activities of the AgNPs was observed against Enterobacter cloacae and Escherichia coli when compared to CS and AS alone. In addition, an in vivo animal model of wound healing activity was tested using mice that were subjected to deep incision wounds. In comparison to the controls, the ointments containing CS-AgNPs and AS-AgNPs stimulated wound closure under histological examination and accelerated the deposition of granulation tissue and collagen in the wound area. The wound healing activity of the ointments containing CS-AgNPs and AS-AgNPs are comparable to that of a commercial formulation of silver sulfadiazine even though the newly prepared ointments contain a lower silver concentration. Therefore, the newly prepared AgNPs demonstrate potential for use as an attractive biocompatible nanocomposite for topical applications in the treatment of wounds. [ABSTRACT FROM AUTHOR]
Copyright of Nanotechnology is the property of IOP Publishing and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Wound healing and antibacterial activities of chondroitin sulfate- and acharan sulfate-reduced silver nanoparticles.
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  Data: <searchLink fieldCode="AR" term="%22Im%2C+A-Rang%22">Im, A-Rang</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kim%2C+Jee+Young%22">Kim, Jee Young</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kim%2C+Hyun-Seok%22">Kim, Hyun-Seok</searchLink><relatesTo>2</relatesTo><i> kims@snu.ac.kr</i><br /><searchLink fieldCode="AR" term="%22Cho%2C+Seonho%22">Cho, Seonho</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Park%2C+Youmie%22">Park, Youmie</searchLink><relatesTo>2,3</relatesTo><i> youmiep@inje.ac.kr</i><br /><searchLink fieldCode="AR" term="%22Kim%2C+Yeong+Shik%22">Kim, Yeong Shik</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Nanotechnology%22">Nanotechnology</searchLink>. 10/4/2013, Vol. 24 Issue 39, p395102-395113. 12p.
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  Data: <searchLink fieldCode="DE" term="%22Wound+healing%22">Wound healing</searchLink><br /><searchLink fieldCode="DE" term="%22Chondroitin+sulfates%22">Chondroitin sulfates</searchLink><br /><searchLink fieldCode="DE" term="%22Silver+nanoparticles%22">Silver nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Antibacterial+agents%22">Antibacterial agents</searchLink><br /><searchLink fieldCode="DE" term="%22Biomedical+materials%22">Biomedical materials</searchLink><br /><searchLink fieldCode="DE" term="%22Glycosaminoglycans%22">Glycosaminoglycans</searchLink>
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  Data: For topical applications in wound healing, silver nanoparticles (AgNPs) have attracted much attention as antibacterial agents. Herein, we describe a green-synthetic route for the production of biocompatible and crystalline AgNPs using two glycosaminoglycans, chondroitin sulfate (CS) and acharan sulfate (AS), as reducing agents. The synthetic approach avoids the use of toxic chemicals, and the yield of AgNPs formation is found to be 98.1% and 91.1% for the chondroitin sulfate-reduced silver nanoparticles (CS-AgNPs) and the acharan sulfate-reduced silver nanoparticles (AS-AgNPs), respectively. Nanoparticles with mostly spherical and amorphous shapes were observed, with an average diameter of 6.16 ± 2.26 nm for CS-AgNPs and 5.79 ± 3.10 nm for AS-AgNPs. Images of the CS-AgNPs obtained from atomic force microscopy revealed the self-assembled structure of CS was similar to a densely packed woven mat with AgNPs sprinkled on the CS. These nanoparticles were stable under cell culture conditions without any noticeable aggregation. An approximately 128-fold enhancement of the antibacterial activities of the AgNPs was observed against Enterobacter cloacae and Escherichia coli when compared to CS and AS alone. In addition, an in vivo animal model of wound healing activity was tested using mice that were subjected to deep incision wounds. In comparison to the controls, the ointments containing CS-AgNPs and AS-AgNPs stimulated wound closure under histological examination and accelerated the deposition of granulation tissue and collagen in the wound area. The wound healing activity of the ointments containing CS-AgNPs and AS-AgNPs are comparable to that of a commercial formulation of silver sulfadiazine even though the newly prepared ointments contain a lower silver concentration. Therefore, the newly prepared AgNPs demonstrate potential for use as an attractive biocompatible nanocomposite for topical applications in the treatment of wounds. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Nanotechnology is the property of IOP Publishing and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1088/0957-4484/24/39/395102
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      – Code: eng
        Text: English
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        PageCount: 12
        StartPage: 395102
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      – SubjectFull: Wound healing
        Type: general
      – SubjectFull: Chondroitin sulfates
        Type: general
      – SubjectFull: Silver nanoparticles
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      – SubjectFull: Antibacterial agents
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      – SubjectFull: Biomedical materials
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      – SubjectFull: Glycosaminoglycans
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      – TitleFull: Wound healing and antibacterial activities of chondroitin sulfate- and acharan sulfate-reduced silver nanoparticles.
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              Text: 10/4/2013
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