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An ex Vivo Human Lung Model for Ultrasound-Guided High-Intensity Focused Ultrasound Therapy Using Lung Flooding.

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Title: An ex Vivo Human Lung Model for Ultrasound-Guided High-Intensity Focused Ultrasound Therapy Using Lung Flooding.
Authors: Wolfram, Frank1 Frank.Wolfram@wkg.srh.de, Reichenbach, Jürgen R.2, Lesser, Thomas G.1
Source: Ultrasound in Medicine & Biology. Mar2014, Vol. 40 Issue 3, p496-503. 8p.
Subjects: Ultrasonic imaging, Exposure therapy, Lung physiology, Lung cancer diagnosis, Atelectasis, Attenuation coefficients
Abstract: Abstract: The usability of an ex vivo human lung model for ablation of lung cancer tissue with high-intensity focused ultrasound (HIFU) is described. Lung lobes were flooded with saline, with no gas remaining after complete atelectasis. The tumor was delineated sono-morphologically. Speed of sound, tissue density and ultrasound attenuation were measured for flooded lung and different pulmonary cancer tissues. The acoustic impedance of lung cancer tissue (1.6–1.9 mega-Rayleighs) was higher than that of water, as was its attenuation coefficient (0.31–0.44 dB/cm/MHz) compared with that of the flooded lung (0.12 dB/cm/MHz). After application of HIFU, the temperature in centrally located lung cancer surrounded by the flooded lung increased as high as 80°C, which is sufficient for treatment. On the basis of these preliminary results, ultrasound-guided HIFU ablation of lung cancer, by lung flooding with saline, appears feasible and should be explored in future clinical studies. [Copyright &y& Elsevier]
Copyright of Ultrasound in Medicine & Biology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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PubType: Academic Journal
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  Data: An ex Vivo Human Lung Model for Ultrasound-Guided High-Intensity Focused Ultrasound Therapy Using Lung Flooding.
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  Data: <searchLink fieldCode="JN" term="%22Ultrasound+in+Medicine+%26+Biology%22">Ultrasound in Medicine & Biology</searchLink>. Mar2014, Vol. 40 Issue 3, p496-503. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Ultrasonic+imaging%22">Ultrasonic imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Exposure+therapy%22">Exposure therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Lung+physiology%22">Lung physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Lung+cancer+diagnosis%22">Lung cancer diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Atelectasis%22">Atelectasis</searchLink><br /><searchLink fieldCode="DE" term="%22Attenuation+coefficients%22">Attenuation coefficients</searchLink>
– Name: Abstract
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  Data: Abstract: The usability of an ex vivo human lung model for ablation of lung cancer tissue with high-intensity focused ultrasound (HIFU) is described. Lung lobes were flooded with saline, with no gas remaining after complete atelectasis. The tumor was delineated sono-morphologically. Speed of sound, tissue density and ultrasound attenuation were measured for flooded lung and different pulmonary cancer tissues. The acoustic impedance of lung cancer tissue (1.6–1.9 mega-Rayleighs) was higher than that of water, as was its attenuation coefficient (0.31–0.44 dB/cm/MHz) compared with that of the flooded lung (0.12 dB/cm/MHz). After application of HIFU, the temperature in centrally located lung cancer surrounded by the flooded lung increased as high as 80°C, which is sufficient for treatment. On the basis of these preliminary results, ultrasound-guided HIFU ablation of lung cancer, by lung flooding with saline, appears feasible and should be explored in future clinical studies. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Ultrasound in Medicine & Biology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=94304500
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        Value: 10.1016/j.ultrasmedbio.2013.11.007
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        Text: English
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      – SubjectFull: Ultrasonic imaging
        Type: general
      – SubjectFull: Exposure therapy
        Type: general
      – SubjectFull: Lung physiology
        Type: general
      – SubjectFull: Lung cancer diagnosis
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      – SubjectFull: Atelectasis
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      – SubjectFull: Attenuation coefficients
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      – TitleFull: An ex Vivo Human Lung Model for Ultrasound-Guided High-Intensity Focused Ultrasound Therapy Using Lung Flooding.
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              Text: Mar2014
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