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Human radiation dosimetry of 6-[18F]FDG predicted from preclinical studies.

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Title: Human radiation dosimetry of 6-[18F]FDG predicted from preclinical studies.
Authors: Muzic, Raymond F.1 raymond.muzic@case.edu, Chandramouli, Visvanathan1, Huang, Hsuan Ming2, Wu, Chunying2, Hatami, Ahmad1, Ismail Beigi, Faramarz3
Source: Medical Physics. Mar2014, Vol. 41 Issue 3, p1-N.PAG. 6p.
Subjects: Radiation dosimetry, Glucose transporters, Logical prediction, Positron emission tomography, Radionuclide imaging
Abstract: Purpose: The authors are developing 6-[18F]fluoro-6-deoxy-D-glucose (6-[18F]FDG) as an in vivo tracer of glucose transport. While 6-[18F]FDG has the same radionuclide half-life as 2-[18F]fluoro-2- deoxy-D-glucose (2-[18F]FDG) which is ubiquitously used for PET imaging, 6-[18F]FDG has special biologic properties and different biodistributions that make it preferable to 2-[18F]FDG for assessing glucose transport. In preparation for 6-[18F]FDG use in human PET scanning, the authors would like to determine the amount of 6-[18F]FDG to inject while maintaining radiation doses in a safe range. Methods: Rats were injected with 6-[18F]FDG, euthanized at specified times, and tissues were collected and assayed for activity content. For each tissue sample, the percent of injected dose per gram was calculated and extrapolated to that for humans in order to construct predicted time-courses. Residence times were calculated as areas under the curves and were used as inputs to OLINDA/EXM in order to calculate the radiation doses. Results: Unlike with 2-[18F]FDG for which the urinary bladder wall receives the highest absorbed dose due to urinary excretion, with 6-[18F]FDG there is little urinary excretion and osteogenic cells and the liver are predicted to receive the highest absorbed doses: 0.027 mGy/MBq (0.100 rad/mCi) and 0.018 mGy/MBq (0.066 rad/mCi), respectively. Also, the effective dose from 6-[18F]FDG, i.e., 0.013 mSv/MBq (0.046 rem/mCi), is predicted to be approximately 30% lower than that from 2-[18F]FDG. Conclusions: 6-[18F]FDG will be safe for use in the PET scanning of humans. [ABSTRACT FROM AUTHOR]
Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Human radiation dosimetry of 6-[<superscript>18</superscript>F]FDG predicted from preclinical studies.
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  Data: <searchLink fieldCode="JN" term="%22Medical+Physics%22">Medical Physics</searchLink>. Mar2014, Vol. 41 Issue 3, p1-N.PAG. 6p.
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  Data: <searchLink fieldCode="DE" term="%22Radiation+dosimetry%22">Radiation dosimetry</searchLink><br /><searchLink fieldCode="DE" term="%22Glucose+transporters%22">Glucose transporters</searchLink><br /><searchLink fieldCode="DE" term="%22Logical+prediction%22">Logical prediction</searchLink><br /><searchLink fieldCode="DE" term="%22Positron+emission+tomography%22">Positron emission tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Radionuclide+imaging%22">Radionuclide imaging</searchLink>
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  Data: Purpose: The authors are developing 6-[18F]fluoro-6-deoxy-D-glucose (6-[18F]FDG) as an in vivo tracer of glucose transport. While 6-[18F]FDG has the same radionuclide half-life as 2-[18F]fluoro-2- deoxy-D-glucose (2-[18F]FDG) which is ubiquitously used for PET imaging, 6-[18F]FDG has special biologic properties and different biodistributions that make it preferable to 2-[18F]FDG for assessing glucose transport. In preparation for 6-[18F]FDG use in human PET scanning, the authors would like to determine the amount of 6-[18F]FDG to inject while maintaining radiation doses in a safe range. Methods: Rats were injected with 6-[18F]FDG, euthanized at specified times, and tissues were collected and assayed for activity content. For each tissue sample, the percent of injected dose per gram was calculated and extrapolated to that for humans in order to construct predicted time-courses. Residence times were calculated as areas under the curves and were used as inputs to OLINDA/EXM in order to calculate the radiation doses. Results: Unlike with 2-[18F]FDG for which the urinary bladder wall receives the highest absorbed dose due to urinary excretion, with 6-[18F]FDG there is little urinary excretion and osteogenic cells and the liver are predicted to receive the highest absorbed doses: 0.027 mGy/MBq (0.100 rad/mCi) and 0.018 mGy/MBq (0.066 rad/mCi), respectively. Also, the effective dose from 6-[18F]FDG, i.e., 0.013 mSv/MBq (0.046 rem/mCi), is predicted to be approximately 30% lower than that from 2-[18F]FDG. Conclusions: 6-[18F]FDG will be safe for use in the PET scanning of humans. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – TitleFull: Human radiation dosimetry of 6-[18F]FDG predicted from preclinical studies.
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              Text: Mar2014
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