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Evaluation of 99Mo and 99mTc Productions Based on a High-Performance Cyclotron.

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Title: Evaluation of 99Mo and 99mTc Productions Based on a High-Performance Cyclotron.
Authors: Esposito, J.1 juan.esposito@lnl.infn.it, Vecchi, G.1,2, Pupillo, G.2, Taibi, A.2, Uccelli, L.3, Boschi, A.3, Gambaccini, M.2
Source: Science & Technology of Nuclear Installations. 2013, p1-14. 14p.
Subjects: Cyclotrons, Particle accelerators, Resonance accelerators, Chromium group, Transition metals
Abstract: Following preliminary feasibility studies which started at LegnaroNational Laboratories (LNL) in 2011, the ItalianNational Institute for Nuclear Physics (INFN) research activities are underway aiming at the alternative, accelerator-driven, 99Mo/ 99mTc production routes. One of the most promising approaches is to use 100Mo-enriched (i.e., >99%) molybdenum metallic targets, bombarded with high-beam-current, high-energy proton cyclotrons. In order to get a comprehensivemap of radionuclides expected, a detailed theoretical investigation has been carried out using the TALYS-TENDL 2012 excitation functions extended up to (p,6n), (p,p5n), and (p,2p4n) levels. A series of quality parameters have thus been calculated both at the end of beam (EOB) and at longer times. Results point out that accelerator-99Mo is of limited interest for a possible massive production because of the quite low specific activity with respect to reactor-99Mo. Accelerator- 99mTc quality parameters (i.e., radionuclidic purity (RNP), isotopic purity (IP), and specific activities) calculated are instead quite close to the generator-Tc. Calculations at 15, 20, and 25MeV have thus been performed to assess the best operative irradiation condition for 99mTc production while minimizing both the short-lived and longlived Tc contaminant radionuclides. Although present in minimum quantities, Tc contaminants may indeed have an impact either on the pharmaceutical labeling procedures or on contributing to patient radiation dose during the diagnostic procedures. [ABSTRACT FROM AUTHOR]
Copyright of Science & Technology of Nuclear Installations is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Evaluation of <superscript>99</superscript>Mo and <superscript>99m</superscript>Tc Productions Based on a High-Performance Cyclotron.
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  Data: Following preliminary feasibility studies which started at LegnaroNational Laboratories (LNL) in 2011, the ItalianNational Institute for Nuclear Physics (INFN) research activities are underway aiming at the alternative, accelerator-driven, 99Mo/ 99mTc production routes. One of the most promising approaches is to use 100Mo-enriched (i.e., >99%) molybdenum metallic targets, bombarded with high-beam-current, high-energy proton cyclotrons. In order to get a comprehensivemap of radionuclides expected, a detailed theoretical investigation has been carried out using the TALYS-TENDL 2012 excitation functions extended up to (p,6n), (p,p5n), and (p,2p4n) levels. A series of quality parameters have thus been calculated both at the end of beam (EOB) and at longer times. Results point out that accelerator-99Mo is of limited interest for a possible massive production because of the quite low specific activity with respect to reactor-99Mo. Accelerator- 99mTc quality parameters (i.e., radionuclidic purity (RNP), isotopic purity (IP), and specific activities) calculated are instead quite close to the generator-Tc. Calculations at 15, 20, and 25MeV have thus been performed to assess the best operative irradiation condition for 99mTc production while minimizing both the short-lived and longlived Tc contaminant radionuclides. Although present in minimum quantities, Tc contaminants may indeed have an impact either on the pharmaceutical labeling procedures or on contributing to patient radiation dose during the diagnostic procedures. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science & Technology of Nuclear Installations is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1155/2013/972381
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      – SubjectFull: Resonance accelerators
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      – SubjectFull: Chromium group
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              Text: 2013
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