Bibliographic Details
| Title: |
Hexanes/acetonitrile: a binary solvent system for the efficient monosilylation of symmetric primary and secondary diols. |
| Authors: |
Wilke, Burkhardt I.1,2, Dornan, Mark H.2, Yeung, Jon2, Boddy, Christopher N.2, Pinto, Atahualpa3 atpinto@syr.edu |
| Source: |
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Apr2014, Vol. 55 Issue 16, p2600-2602. 3p. |
| Subjects: |
Solvents, Silylation, Glycols, Acetonitrile, Natural products, Organic synthesis |
| Abstract: |
Abstract: Symmetric diols are useful compounds in the synthesis of natural products, their value often dependent on their successful monoprotection. A general and simple method for the monosilylation of symmetrical primary and secondary diols is reported. The method exploits the solubility differential of diols and their monosilylated counterparts in a binary hexanes/acetonitrile solvent system. [Copyright &y& Elsevier] |
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| Database: |
Engineering Source |
