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Performance improvement and functionalization of an electrode array for retinal prosthesis by iridium oxide coating and introduction of smart-wiring technology using CMOS microchips.

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Title: Performance improvement and functionalization of an electrode array for retinal prosthesis by iridium oxide coating and introduction of smart-wiring technology using CMOS microchips.
Authors: Noda, Toshihiko1 t-noda@ms.naist.jp, Sasagawa, Kiyotaka1, Tokuda, Takashi1, Terasawa, Yasuo2, Tashiro, Hiroyuki3, Kanda, Hiroyuki4, Fujikado, Takashi4, Ohta, Jun1
Source: Sensors & Actuators A: Physical. May2014, Vol. 211, p27-37. 11p.
Subjects: Performance evaluation, CMOS memory circuits, Integrated circuits, Iridium oxide films, Miniature electronic equipment, Electric wiring
Abstract: Abstract: The improvement of an electrode array for retinal prosthesis is described. Two elements of fundamental technology required in next-generation retinal prosthesis, the miniaturization of and wiring of a stimulus electrode, were investigated. To miniaturize the stimulus electrode without performance degradation, surface coating by iridium oxide (IrOx), a high performance material, was introduced. The electrochemical properties and durability of an IrOx coated electrode were evaluated through in vitro and in vivo experimentation. Results showed that IrOx coating delivers a higher performance with sufficient durability and contributes to the miniaturization of the electrode without degrading the stimulus capability. Smart-wiring technology using CMOS microchips was also investigated. A prototype electrode array with CMOS microchips was fabricated to clarify the concept. A dedicated CMOS microchip was hybrid-integrated into a stimulus electrode array. Results of in vivo experiments showed that the fabricated array stimulated retinal cells effectively. Miniaturized electrodes with an IrOx coating and smart-wiring technology enable the fabrication of a super-multi-channel (i.e., more than 1000) electrode array, which is required for next-generation retinal prosthesis. [Copyright &y& Elsevier]
Copyright of Sensors & Actuators A: Physical is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 95722229
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Performance improvement and functionalization of an electrode array for retinal prosthesis by iridium oxide coating and introduction of smart-wiring technology using CMOS microchips.
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  Data: <searchLink fieldCode="AR" term="%22Noda%2C+Toshihiko%22">Noda, Toshihiko</searchLink><relatesTo>1</relatesTo><i> t-noda@ms.naist.jp</i><br /><searchLink fieldCode="AR" term="%22Sasagawa%2C+Kiyotaka%22">Sasagawa, Kiyotaka</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Tokuda%2C+Takashi%22">Tokuda, Takashi</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Terasawa%2C+Yasuo%22">Terasawa, Yasuo</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Tashiro%2C+Hiroyuki%22">Tashiro, Hiroyuki</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Kanda%2C+Hiroyuki%22">Kanda, Hiroyuki</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Fujikado%2C+Takashi%22">Fujikado, Takashi</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Ohta%2C+Jun%22">Ohta, Jun</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Sensors+%26+Actuators+A%3A+Physical%22">Sensors & Actuators A: Physical</searchLink>. May2014, Vol. 211, p27-37. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Performance+evaluation%22">Performance evaluation</searchLink><br /><searchLink fieldCode="DE" term="%22CMOS+memory+circuits%22">CMOS memory circuits</searchLink><br /><searchLink fieldCode="DE" term="%22Integrated+circuits%22">Integrated circuits</searchLink><br /><searchLink fieldCode="DE" term="%22Iridium+oxide+films%22">Iridium oxide films</searchLink><br /><searchLink fieldCode="DE" term="%22Miniature+electronic+equipment%22">Miniature electronic equipment</searchLink><br /><searchLink fieldCode="DE" term="%22Electric+wiring%22">Electric wiring</searchLink>
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  Label: Abstract
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  Data: Abstract: The improvement of an electrode array for retinal prosthesis is described. Two elements of fundamental technology required in next-generation retinal prosthesis, the miniaturization of and wiring of a stimulus electrode, were investigated. To miniaturize the stimulus electrode without performance degradation, surface coating by iridium oxide (IrOx), a high performance material, was introduced. The electrochemical properties and durability of an IrOx coated electrode were evaluated through in vitro and in vivo experimentation. Results showed that IrOx coating delivers a higher performance with sufficient durability and contributes to the miniaturization of the electrode without degrading the stimulus capability. Smart-wiring technology using CMOS microchips was also investigated. A prototype electrode array with CMOS microchips was fabricated to clarify the concept. A dedicated CMOS microchip was hybrid-integrated into a stimulus electrode array. Results of in vivo experiments showed that the fabricated array stimulated retinal cells effectively. Miniaturized electrodes with an IrOx coating and smart-wiring technology enable the fabrication of a super-multi-channel (i.e., more than 1000) electrode array, which is required for next-generation retinal prosthesis. [Copyright &y& Elsevier]
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  Data: <i>Copyright of Sensors & Actuators A: Physical is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.sna.2014.03.001
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      – SubjectFull: Integrated circuits
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      – SubjectFull: Iridium oxide films
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      – SubjectFull: Miniature electronic equipment
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      – SubjectFull: Electric wiring
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              Text: May2014
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