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Combined radiofrequency ablation and ethanol injection with a multipronged needle for the treatment of medium and large hepatocellular carcinoma.

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Title: Combined radiofrequency ablation and ethanol injection with a multipronged needle for the treatment of medium and large hepatocellular carcinoma.
Authors: Huang, Guangliang1, Lin, Manxia, Xie, Xiaoyan xxy1992@21cn.com, Liu, Baoxian1, Xu, Zuofeng1, Lencioni, Riccardo2, Lu, Mingde, Kuang, Ming kuangm@mail.sysu.edu.cn
Source: European Radiology. Jul2014, Vol. 24 Issue 7, p1565-1571. 7p. 2 Black and White Photographs, 3 Charts.
Subjects: Radio frequency, Liver cancer, Neoplastic cell transformation, Ethanol, Tumors
Abstract: Objective: To evaluate the efficacy and safety of combined radiofrequency ablation (RFA) and ethanol injection with a multipronged needle in the treatment of medium (3.1-5.0 cm) and large (5.1-7.0 cm) hepatocellular carcinoma (HCC). Methods: A total of 65 patients with 67 HCC nodules were enrolled in this prospective study. All of them received the treatment of combined RFA and multipronged ethanol injection percutaneously. Results: The average volume of injected ethanol was 14.4 ± 4.1 ml (range, 9-30 ml). The average number of RFA electrode insertions was 1.7 ± 0.8 (range, 1-4). The rate of initial local complete response (CR) was 94.0 % (63/67). After additional treatment, technical success was achieved in all HCC nodules. There were no treatment-related deaths, and major complications were observed in 3 (4.6 %) patients. After a mean follow-up of 20.0 ± 7.6 months, local tumour progression was observed in 10 (10/67, 14.9 %) tumours, whereas distant recurrence developed in 32 (32/65, 49.2 %) patients. The 1-year and 2-year survival rates were 93.1 % and 88.1 %, respectively. Conclusion: The combination of RFA and multipronged ethanol injection in the treatment of medium and large HCC is safe and effective with a high rate of local tumour control. Key Points: • Combined radiofrequency ablation and multipronged ethanol injection is a new therapeutic strategy • Treatment is safe and effective for medium and large hepatocellular carcinoma ( HCC) • A multipronged needle allows for a homogeneous ethanol distribution [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Combined radiofrequency ablation and ethanol injection with a multipronged needle for the treatment of medium and large hepatocellular carcinoma.
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  Data: <searchLink fieldCode="AR" term="%22Huang%2C+Guangliang%22">Huang, Guangliang</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Lin%2C+Manxia%22">Lin, Manxia</searchLink><br /><searchLink fieldCode="AR" term="%22Xie%2C+Xiaoyan%22">Xie, Xiaoyan</searchLink><i> xxy1992@21cn.com</i><br /><searchLink fieldCode="AR" term="%22Liu%2C+Baoxian%22">Liu, Baoxian</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Xu%2C+Zuofeng%22">Xu, Zuofeng</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Lencioni%2C+Riccardo%22">Lencioni, Riccardo</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Lu%2C+Mingde%22">Lu, Mingde</searchLink><br /><searchLink fieldCode="AR" term="%22Kuang%2C+Ming%22">Kuang, Ming</searchLink><i> kuangm@mail.sysu.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Jul2014, Vol. 24 Issue 7, p1565-1571. 7p. 2 Black and White Photographs, 3 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Radio+frequency%22">Radio frequency</searchLink><br /><searchLink fieldCode="DE" term="%22Liver+cancer%22">Liver cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Neoplastic+cell+transformation%22">Neoplastic cell transformation</searchLink><br /><searchLink fieldCode="DE" term="%22Ethanol%22">Ethanol</searchLink><br /><searchLink fieldCode="DE" term="%22Tumors%22">Tumors</searchLink>
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  Data: Objective: To evaluate the efficacy and safety of combined radiofrequency ablation (RFA) and ethanol injection with a multipronged needle in the treatment of medium (3.1-5.0 cm) and large (5.1-7.0 cm) hepatocellular carcinoma (HCC). Methods: A total of 65 patients with 67 HCC nodules were enrolled in this prospective study. All of them received the treatment of combined RFA and multipronged ethanol injection percutaneously. Results: The average volume of injected ethanol was 14.4 ± 4.1 ml (range, 9-30 ml). The average number of RFA electrode insertions was 1.7 ± 0.8 (range, 1-4). The rate of initial local complete response (CR) was 94.0 % (63/67). After additional treatment, technical success was achieved in all HCC nodules. There were no treatment-related deaths, and major complications were observed in 3 (4.6 %) patients. After a mean follow-up of 20.0 ± 7.6 months, local tumour progression was observed in 10 (10/67, 14.9 %) tumours, whereas distant recurrence developed in 32 (32/65, 49.2 %) patients. The 1-year and 2-year survival rates were 93.1 % and 88.1 %, respectively. Conclusion: The combination of RFA and multipronged ethanol injection in the treatment of medium and large HCC is safe and effective with a high rate of local tumour control. Key Points: • Combined radiofrequency ablation and multipronged ethanol injection is a new therapeutic strategy • Treatment is safe and effective for medium and large hepatocellular carcinoma ( HCC) • A multipronged needle allows for a homogeneous ethanol distribution [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Jul2014
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