Combined radiofrequency ablation and ethanol injection with a multipronged needle for the treatment of medium and large hepatocellular carcinoma.
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| Title: | Combined radiofrequency ablation and ethanol injection with a multipronged needle for the treatment of medium and large hepatocellular carcinoma. |
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| Authors: | Huang, Guangliang1, Lin, Manxia, Xie, Xiaoyan xxy1992@21cn.com, Liu, Baoxian1, Xu, Zuofeng1, Lencioni, Riccardo2, Lu, Mingde, Kuang, Ming kuangm@mail.sysu.edu.cn |
| Source: | European Radiology. Jul2014, Vol. 24 Issue 7, p1565-1571. 7p. 2 Black and White Photographs, 3 Charts. |
| Subjects: | Radio frequency, Liver cancer, Neoplastic cell transformation, Ethanol, Tumors |
| Abstract: | Objective: To evaluate the efficacy and safety of combined radiofrequency ablation (RFA) and ethanol injection with a multipronged needle in the treatment of medium (3.1-5.0 cm) and large (5.1-7.0 cm) hepatocellular carcinoma (HCC). Methods: A total of 65 patients with 67 HCC nodules were enrolled in this prospective study. All of them received the treatment of combined RFA and multipronged ethanol injection percutaneously. Results: The average volume of injected ethanol was 14.4 ± 4.1 ml (range, 9-30 ml). The average number of RFA electrode insertions was 1.7 ± 0.8 (range, 1-4). The rate of initial local complete response (CR) was 94.0 % (63/67). After additional treatment, technical success was achieved in all HCC nodules. There were no treatment-related deaths, and major complications were observed in 3 (4.6 %) patients. After a mean follow-up of 20.0 ± 7.6 months, local tumour progression was observed in 10 (10/67, 14.9 %) tumours, whereas distant recurrence developed in 32 (32/65, 49.2 %) patients. The 1-year and 2-year survival rates were 93.1 % and 88.1 %, respectively. Conclusion: The combination of RFA and multipronged ethanol injection in the treatment of medium and large HCC is safe and effective with a high rate of local tumour control. Key Points: • Combined radiofrequency ablation and multipronged ethanol injection is a new therapeutic strategy • Treatment is safe and effective for medium and large hepatocellular carcinoma ( HCC) • A multipronged needle allows for a homogeneous ethanol distribution [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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