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Normalization of urinary pteridines by urine specific gravity for early cancer detection.

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Title: Normalization of urinary pteridines by urine specific gravity for early cancer detection.
Authors: Burton, Casey1, Shi, Honglan1, Ma, Yinfa1 yinfa@mst.edu
Source: Clinica Chimica Acta. Aug2014, Vol. 435, p42-47. 6p.
Subjects: Breast cancer diagnosis, Pteridines, Biomarkers, Urination, Liquid chromatography-mass spectrometry, Neopterin
Abstract: Abstract: Background: Urinary biomarkers, such as pteridines, require normalization with respect to an individual's hydration status and time since last urination. Conventional creatinine-based corrections are affected by a multitude of patient factors whereas urine specific gravity (USG) is a bulk specimen property that may better resist those same factors. We examined the performance of traditional creatinine adjustments relative to USG to six urinary pteridines in aggressive and benign breast cancers. Methods: 6-Biopterin, neopterin, pterin, 6-hydroxymethylpterin, isoxanthopterin, xanthopterin, and creatinine were analyzed in 50 urine specimens with a previously developed liquid chromatography–tandem mass spectrometry technique. Creatinine and USG performance were evaluated with non-parametric Mann–Whitney hypothesis testing. Results: USG and creatinine were moderately correlated (r =0.857) with deviations occurring in dilute and concentrated specimens. In 48 aggressive and benign breast cancers, normalization by USG significantly outperformed creatinine adjustments which marginally outperformed uncorrected pteridines in predicting pathological status. In addition, isoxanthopterin and xanthopterin were significantly higher in pathological specimens when normalized by USG. Conclusion: USG, as a bulk property, can provide better performance over creatinine-based normalizations for urinary pteridines in cancer detection applications. [Copyright &y& Elsevier]
Copyright of Clinica Chimica Acta is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 96448874
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  Data: Normalization of urinary pteridines by urine specific gravity for early cancer detection.
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  Data: <searchLink fieldCode="AR" term="%22Burton%2C+Casey%22">Burton, Casey</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Shi%2C+Honglan%22">Shi, Honglan</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ma%2C+Yinfa%22">Ma, Yinfa</searchLink><relatesTo>1</relatesTo><i> yinfa@mst.edu</i>
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  Data: <searchLink fieldCode="DE" term="%22Breast+cancer+diagnosis%22">Breast cancer diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Pteridines%22">Pteridines</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Urination%22">Urination</searchLink><br /><searchLink fieldCode="DE" term="%22Liquid+chromatography-mass+spectrometry%22">Liquid chromatography-mass spectrometry</searchLink><br /><searchLink fieldCode="DE" term="%22Neopterin%22">Neopterin</searchLink>
– Name: Abstract
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  Data: Abstract: Background: Urinary biomarkers, such as pteridines, require normalization with respect to an individual's hydration status and time since last urination. Conventional creatinine-based corrections are affected by a multitude of patient factors whereas urine specific gravity (USG) is a bulk specimen property that may better resist those same factors. We examined the performance of traditional creatinine adjustments relative to USG to six urinary pteridines in aggressive and benign breast cancers. Methods: 6-Biopterin, neopterin, pterin, 6-hydroxymethylpterin, isoxanthopterin, xanthopterin, and creatinine were analyzed in 50 urine specimens with a previously developed liquid chromatography–tandem mass spectrometry technique. Creatinine and USG performance were evaluated with non-parametric Mann–Whitney hypothesis testing. Results: USG and creatinine were moderately correlated (r =0.857) with deviations occurring in dilute and concentrated specimens. In 48 aggressive and benign breast cancers, normalization by USG significantly outperformed creatinine adjustments which marginally outperformed uncorrected pteridines in predicting pathological status. In addition, isoxanthopterin and xanthopterin were significantly higher in pathological specimens when normalized by USG. Conclusion: USG, as a bulk property, can provide better performance over creatinine-based normalizations for urinary pteridines in cancer detection applications. [Copyright &y& Elsevier]
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  Data: <i>Copyright of Clinica Chimica Acta is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.cca.2014.04.022
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      – Code: eng
        Text: English
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        PageCount: 6
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      – SubjectFull: Breast cancer diagnosis
        Type: general
      – SubjectFull: Pteridines
        Type: general
      – SubjectFull: Biomarkers
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      – SubjectFull: Urination
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      – SubjectFull: Liquid chromatography-mass spectrometry
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      – SubjectFull: Neopterin
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              Text: Aug2014
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