View in EDS

Incomplete glandular ablation after salvage cryotherapy for recurrent prostate cancer after radiotherapy

Saved in:
Bibliographic Details
Title: Incomplete glandular ablation after salvage cryotherapy for recurrent prostate cancer after radiotherapy
Authors: Izawa, Jonathan I.1, Morganstern, Nora2, Chan, Deva M.1, Levy, Lawrence B.3, Scott, Shellie M.1, Pisters, Louis L.1 lpisters@mail.mdanderson.org
Source: International Journal of Radiation Oncology, Biology, Physics. Jun2003, Vol. 56 Issue 2, p468-472. 5p.
Subjects: Cold therapy, Prostate cancer, Biopsy, Evaluation research, Cancer relapse, Prostate-specific antigen, Research funding, Salvage therapy, Prostate tumors, Cryosurgery, Prostate, Analysis of variance, Research methodology, Research, Prognosis, Comparative studies, Regression analysis, Impact of Event Scale
Abstract: : PurposeTo determine the clinical variables associated with inadequate salvage cryotherapy and to correlate the disease-free survival rates associated with biopsy results in prostate cancer (CaP).: Methods and materialsBetween July 1992 and January 1995, 150 patients underwent salvage cryotherapy for locally recurrent CaP. Biopsy specimens were examined for the presence of cancer cells and normal or atypical glands, all of which were considered evidence of inadequate cryotherapy. Clinical variables, as predictors of biopsy results, were evaluated with univariate and multivariate analyses. The impact of the biopsy results on disease-free survival was also determined.: ResultsThe number of cryoprobes and freeze-thaw cycles correlated with inadequate cryotherapy (p = 0.037 and p = 0.0022, respectively). The number of freeze-thaw cycles was an independent predictor of inadequate cryotherapy (p = 0.003). The finding of cancer cells in the biopsy specimens was the only histopathologic variable that affected disease-free survival (p = 0.016).: ConclusionComplete ablation of the prostate gland and tumor is difficult to achieve with salvage cryotherapy. To optimize for complete ablation, salvage cryotherapy should include at least two freeze-thaw cycles and a minimum of five cryoprobes. The finding of atypical or normal epithelial tissue in biopsy specimens after salvage cryotherapy is not predictive of biochemical failure. [Copyright &y& Elsevier]
Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 9657599
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Incomplete glandular ablation after salvage cryotherapy for recurrent prostate cancer after radiotherapy
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Izawa%2C+Jonathan+I%2E%22">Izawa, Jonathan I.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Morganstern%2C+Nora%22">Morganstern, Nora</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Chan%2C+Deva+M%2E%22">Chan, Deva M.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Levy%2C+Lawrence+B%2E%22">Levy, Lawrence B.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Scott%2C+Shellie+M%2E%22">Scott, Shellie M.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Pisters%2C+Louis+L%2E%22">Pisters, Louis L.</searchLink><relatesTo>1</relatesTo><i> lpisters@mail.mdanderson.org</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Radiation+Oncology%2C+Biology%2C+Physics%22">International Journal of Radiation Oncology, Biology, Physics</searchLink>. Jun2003, Vol. 56 Issue 2, p468-472. 5p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Cold+therapy%22">Cold therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Prostate+cancer%22">Prostate cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Biopsy%22">Biopsy</searchLink><br /><searchLink fieldCode="DE" term="%22Evaluation+research%22">Evaluation research</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+relapse%22">Cancer relapse</searchLink><br /><searchLink fieldCode="DE" term="%22Prostate-specific+antigen%22">Prostate-specific antigen</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Salvage+therapy%22">Salvage therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Prostate+tumors%22">Prostate tumors</searchLink><br /><searchLink fieldCode="DE" term="%22Cryosurgery%22">Cryosurgery</searchLink><br /><searchLink fieldCode="DE" term="%22Prostate%22">Prostate</searchLink><br /><searchLink fieldCode="DE" term="%22Analysis+of+variance%22">Analysis of variance</searchLink><br /><searchLink fieldCode="DE" term="%22Research+methodology%22">Research methodology</searchLink><br /><searchLink fieldCode="DE" term="%22Research%22">Research</searchLink><br /><searchLink fieldCode="DE" term="%22Prognosis%22">Prognosis</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Regression+analysis%22">Regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Impact+of+Event+Scale%22">Impact of Event Scale</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: : PurposeTo determine the clinical variables associated with inadequate salvage cryotherapy and to correlate the disease-free survival rates associated with biopsy results in prostate cancer (CaP).: Methods and materialsBetween July 1992 and January 1995, 150 patients underwent salvage cryotherapy for locally recurrent CaP. Biopsy specimens were examined for the presence of cancer cells and normal or atypical glands, all of which were considered evidence of inadequate cryotherapy. Clinical variables, as predictors of biopsy results, were evaluated with univariate and multivariate analyses. The impact of the biopsy results on disease-free survival was also determined.: ResultsThe number of cryoprobes and freeze-thaw cycles correlated with inadequate cryotherapy (p = 0.037 and p = 0.0022, respectively). The number of freeze-thaw cycles was an independent predictor of inadequate cryotherapy (p = 0.003). The finding of cancer cells in the biopsy specimens was the only histopathologic variable that affected disease-free survival (p = 0.016).: ConclusionComplete ablation of the prostate gland and tumor is difficult to achieve with salvage cryotherapy. To optimize for complete ablation, salvage cryotherapy should include at least two freeze-thaw cycles and a minimum of five cryoprobes. The finding of atypical or normal epithelial tissue in biopsy specimens after salvage cryotherapy is not predictive of biochemical failure. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=9657599
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/S0360-3016(02)04574-1
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 5
        StartPage: 468
    Subjects:
      – SubjectFull: Cold therapy
        Type: general
      – SubjectFull: Prostate cancer
        Type: general
      – SubjectFull: Biopsy
        Type: general
      – SubjectFull: Evaluation research
        Type: general
      – SubjectFull: Cancer relapse
        Type: general
      – SubjectFull: Prostate-specific antigen
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Salvage therapy
        Type: general
      – SubjectFull: Prostate tumors
        Type: general
      – SubjectFull: Cryosurgery
        Type: general
      – SubjectFull: Prostate
        Type: general
      – SubjectFull: Analysis of variance
        Type: general
      – SubjectFull: Research methodology
        Type: general
      – SubjectFull: Research
        Type: general
      – SubjectFull: Prognosis
        Type: general
      – SubjectFull: Comparative studies
        Type: general
      – SubjectFull: Regression analysis
        Type: general
      – SubjectFull: Impact of Event Scale
        Type: general
    Titles:
      – TitleFull: Incomplete glandular ablation after salvage cryotherapy for recurrent prostate cancer after radiotherapy
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Izawa, Jonathan I.
      – PersonEntity:
          Name:
            NameFull: Morganstern, Nora
      – PersonEntity:
          Name:
            NameFull: Chan, Deva M.
      – PersonEntity:
          Name:
            NameFull: Levy, Lawrence B.
      – PersonEntity:
          Name:
            NameFull: Scott, Shellie M.
      – PersonEntity:
          Name:
            NameFull: Pisters, Louis L.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: Jun2003
              Type: published
              Y: 2003
          Identifiers:
            – Type: issn-print
              Value: 03603016
          Numbering:
            – Type: volume
              Value: 56
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: International Journal of Radiation Oncology, Biology, Physics
              Type: main
ResultId 1