Bibliographic Details
| Title: |
Small molecule interactions with protein-tyrosine phosphatase PTP1B and their use in inhibitor... |
| Authors: |
Burke Jr., Terrence R., Ye, Bin |
| Source: |
Biochemistry. 12/17/96, Vol. 35 Issue 50, p15989. 8p. 5 Color Photographs, 3 Diagrams, 3 Charts. |
| Subjects: |
Phosphatases, Chemical inhibitors |
| Abstract: |
Examines the small molecule interactions with protein-tyrosine phosphatase PTP1B and their use in inhibitor design. Indications that the introduction of a hydroxyl could enhance binding interactions; Determination of the X-ray structure of the PTP1B complex; Revelation of the extensive hydrophobic interactions with the naphthalene system. |
| Database: |
Engineering Source |
