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Small molecule interactions with protein-tyrosine phosphatase PTP1B and their use in inhibitor...

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Title: Small molecule interactions with protein-tyrosine phosphatase PTP1B and their use in inhibitor...
Authors: Burke Jr., Terrence R., Ye, Bin
Source: Biochemistry. 12/17/96, Vol. 35 Issue 50, p15989. 8p. 5 Color Photographs, 3 Diagrams, 3 Charts.
Subjects: Phosphatases, Chemical inhibitors
Abstract: Examines the small molecule interactions with protein-tyrosine phosphatase PTP1B and their use in inhibitor design. Indications that the introduction of a hydroxyl could enhance binding interactions; Determination of the X-ray structure of the PTP1B complex; Revelation of the extensive hydrophobic interactions with the naphthalene system.
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 9712193374
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Small molecule interactions with protein-tyrosine phosphatase PTP1B and their use in inhibitor...
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  Data: <searchLink fieldCode="JN" term="%22Biochemistry%22">Biochemistry</searchLink>. 12/17/96, Vol. 35 Issue 50, p15989. 8p. 5 Color Photographs, 3 Diagrams, 3 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Phosphatases%22">Phosphatases</searchLink><br /><searchLink fieldCode="DE" term="%22Chemical+inhibitors%22">Chemical inhibitors</searchLink>
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  Data: Examines the small molecule interactions with protein-tyrosine phosphatase PTP1B and their use in inhibitor design. Indications that the introduction of a hydroxyl could enhance binding interactions; Determination of the X-ray structure of the PTP1B complex; Revelation of the extensive hydrophobic interactions with the naphthalene system.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=9712193374
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1021/bi961256d
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 15989
    Subjects:
      – SubjectFull: Phosphatases
        Type: general
      – SubjectFull: Chemical inhibitors
        Type: general
    Titles:
      – TitleFull: Small molecule interactions with protein-tyrosine phosphatase PTP1B and their use in inhibitor...
        Type: main
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          Name:
            NameFull: Burke Jr., Terrence R.
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            NameFull: Ye, Bin
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            – D: 17
              M: 12
              Text: 12/17/96
              Type: published
              Y: 1996
          Identifiers:
            – Type: issn-print
              Value: 00062960
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            – Type: volume
              Value: 35
            – Type: issue
              Value: 50
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            – TitleFull: Biochemistry
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