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The transcription factors Sox5 and Sox9 regulate Catsper1 gene expression.

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Title: The transcription factors Sox5 and Sox9 regulate Catsper1 gene expression.
Authors: Mata-Rocha, Minerva1,2, Hernández-Sánchez, Javier2, Guarneros, Gabriel2, de la Chesnaye, Elsa1, Sánchez-Tusié, Ana A.3, Treviño, Claudia L.3, Felix, Ricardo4, Oviedo, Norma1 naoviedoa@yahoo.com.mx
Source: FEBS Letters. Sep2014, Vol. 588 Issue 18, p3352-3360. 9p.
Subjects: Transcription factors, Cloning, SOX transcription factors, Gene expression, Immunoprecipitation
Abstract: Catsper is a Ca 2+ permeable channel required for sperm hyperactivation. In spite of its central role in male fertility, the transcriptional mechanisms that regulate Catsper1 expression are ill defined. In this work, we describe the identification and characterization of important regulatory elements in the murine Catsper1 gene proximal promoter. Four transcription start sites and three functional Sox-binding sites were identified in the Catsper1 promoter. Interestingly, transcription factors Sox5 and Sox9 caused a significant increase in transactivation of the Catsper1 promoter in heterologous systems, and chromatin immunoprecipitation assays showed that both transcription factors interact with the Catsper1 promoter in vivo. These results provide new insights into the molecular mechanisms that control Catsper channel expression. [ABSTRACT FROM AUTHOR]
Copyright of FEBS Letters is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 97933173
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: The transcription factors Sox5 and Sox9 regulate Catsper1 gene expression.
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  Data: <searchLink fieldCode="AR" term="%22Mata-Rocha%2C+Minerva%22">Mata-Rocha, Minerva</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Hernández-Sánchez%2C+Javier%22">Hernández-Sánchez, Javier</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Guarneros%2C+Gabriel%22">Guarneros, Gabriel</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22de+la+Chesnaye%2C+Elsa%22">de la Chesnaye, Elsa</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Sánchez-Tusié%2C+Ana+A%2E%22">Sánchez-Tusié, Ana A.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Treviño%2C+Claudia+L%2E%22">Treviño, Claudia L.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Felix%2C+Ricardo%22">Felix, Ricardo</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Oviedo%2C+Norma%22">Oviedo, Norma</searchLink><relatesTo>1</relatesTo><i> naoviedoa@yahoo.com.mx</i>
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  Data: <searchLink fieldCode="JN" term="%22FEBS+Letters%22">FEBS Letters</searchLink>. Sep2014, Vol. 588 Issue 18, p3352-3360. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Transcription+factors%22">Transcription factors</searchLink><br /><searchLink fieldCode="DE" term="%22Cloning%22">Cloning</searchLink><br /><searchLink fieldCode="DE" term="%22SOX+transcription+factors%22">SOX transcription factors</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+expression%22">Gene expression</searchLink><br /><searchLink fieldCode="DE" term="%22Immunoprecipitation%22">Immunoprecipitation</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Catsper is a Ca 2+ permeable channel required for sperm hyperactivation. In spite of its central role in male fertility, the transcriptional mechanisms that regulate Catsper1 expression are ill defined. In this work, we describe the identification and characterization of important regulatory elements in the murine Catsper1 gene proximal promoter. Four transcription start sites and three functional Sox-binding sites were identified in the Catsper1 promoter. Interestingly, transcription factors Sox5 and Sox9 caused a significant increase in transactivation of the Catsper1 promoter in heterologous systems, and chromatin immunoprecipitation assays showed that both transcription factors interact with the Catsper1 promoter in vivo. These results provide new insights into the molecular mechanisms that control Catsper channel expression. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of FEBS Letters is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.febslet.2014.07.024
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      – Code: eng
        Text: English
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      – SubjectFull: SOX transcription factors
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      – SubjectFull: Gene expression
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      – SubjectFull: Immunoprecipitation
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              Text: Sep2014
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