Bibliographic Details
| Title: |
Single-Walled Carbon Nanotubes Alleviate Autophagic/LysosomalDefects in Primary Glia from a Mouse Model of Alzheimer’s Disease. |
| Authors: |
Xue, Xue1, Wang, Li-Rong1, Sato, Yutaka1, Jiang, Ying1, Berg, Martin1, Yang, Dun-Sheng1, Nixon, Ralph A.1, Liang, Xing-Jie1 |
| Source: |
Nano Letters. Sep2014, Vol. 14 Issue 9, p5110-5117. 8p. |
| Subjects: |
Single walled carbon nanotubes, Animal models of Alzheimer's disease, Autophagy, Neuroglia, Laboratory mice, Amyloid beta-protein precursor |
| Abstract: |
Defectiveautophagy in Alzheimer’s disease (AD) promotesdisease progression in diverse ways. Here, we demonstrate impairedautophagy flux in primary glial cells derived from CRND8 mice thatoverexpress mutant amyloid precursor protein (APP). Functionalizedsingle-walled carbon nanotubes (SWNT) restored normal autophagy byreversing abnormal activation of mTOR signaling and deficits in lysosomalproteolysis, thereby facilitating elimination of autophagic substrates.These findings suggest SWNT as a novel neuroprotective approach toAD therapy. [ABSTRACT FROM AUTHOR] |
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| Database: |
Engineering Source |
