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Single-Walled Carbon Nanotubes Alleviate Autophagic/LysosomalDefects in Primary Glia from a Mouse Model of Alzheimer’s Disease.

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Title: Single-Walled Carbon Nanotubes Alleviate Autophagic/LysosomalDefects in Primary Glia from a Mouse Model of Alzheimer’s Disease.
Authors: Xue, Xue1, Wang, Li-Rong1, Sato, Yutaka1, Jiang, Ying1, Berg, Martin1, Yang, Dun-Sheng1, Nixon, Ralph A.1, Liang, Xing-Jie1
Source: Nano Letters. Sep2014, Vol. 14 Issue 9, p5110-5117. 8p.
Subjects: Single walled carbon nanotubes, Animal models of Alzheimer's disease, Autophagy, Neuroglia, Laboratory mice, Amyloid beta-protein precursor
Abstract: Defectiveautophagy in Alzheimer’s disease (AD) promotesdisease progression in diverse ways. Here, we demonstrate impairedautophagy flux in primary glial cells derived from CRND8 mice thatoverexpress mutant amyloid precursor protein (APP). Functionalizedsingle-walled carbon nanotubes (SWNT) restored normal autophagy byreversing abnormal activation of mTOR signaling and deficits in lysosomalproteolysis, thereby facilitating elimination of autophagic substrates.These findings suggest SWNT as a novel neuroprotective approach toAD therapy. [ABSTRACT FROM AUTHOR]
Copyright of Nano Letters is the property of American Chemical Society and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
An: 98249638
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Single-Walled Carbon Nanotubes Alleviate Autophagic/LysosomalDefects in Primary Glia from a Mouse Model of Alzheimer’s Disease.
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  Data: <searchLink fieldCode="JN" term="%22Nano+Letters%22">Nano Letters</searchLink>. Sep2014, Vol. 14 Issue 9, p5110-5117. 8p.
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  Data: Defectiveautophagy in Alzheimer’s disease (AD) promotesdisease progression in diverse ways. Here, we demonstrate impairedautophagy flux in primary glial cells derived from CRND8 mice thatoverexpress mutant amyloid precursor protein (APP). Functionalizedsingle-walled carbon nanotubes (SWNT) restored normal autophagy byreversing abnormal activation of mTOR signaling and deficits in lysosomalproteolysis, thereby facilitating elimination of autophagic substrates.These findings suggest SWNT as a novel neuroprotective approach toAD therapy. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Nano Letters is the property of American Chemical Society and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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