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Biaxial mechanical properties of the human thoracic and abdominal aorta, common carotid, subclavian, renal and common iliac arteries.

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Title: Biaxial mechanical properties of the human thoracic and abdominal aorta, common carotid, subclavian, renal and common iliac arteries.
Authors: Kamenskiy, Alexey1 Alexey.Kamenskiy@unmc.edu, Dzenis, Yuris2, Kazmi, Syed3, Pemberton, Mark3, Pipinos, Iraklis, Phillips, Nick4, Herber, Kyle5, Woodford, Thomas5, Bowen, Robert6, Lomneth, Carol7, MacTaggart, Jason1 JMacTaggart@unmc.edu
Source: Biomechanics & Modeling in Mechanobiology. Nov2014, Vol. 13 Issue 6, p1341-1359. 19p.
Subjects: Abdominal aorta, Thoracic aorta, Iliac artery, Biomechanics, Arterial diseases, Carotid artery, Subclavian artery, Renal artery
Abstract: The biomechanics of large- and medium-sized arteries influence the pathophysiology of arterial disease and the response to therapeutic interventions. However, a comprehensive comparative analysis of human arterial biaxial mechanical properties has not yet been reported. Planar biaxial extension was used to establish the passive mechanical properties of human thoracic (TA, $$n=8$$ ) and abdominal (AA, $$n=7$$ ) aorta, common carotid (CCA, $$n=21$$ ), subclavian (SA, $$n=12$$ ), renal (RA, $$n=13$$ ) and common iliac (CIA, $$n=16$$ ) arteries from 11 deceased subjects ( $$54\pm 21$$ years old). Histological evaluation determined the structure of each specimen. Experimental data were used to determine constitutive parameters for a structurally motivated nonlinear anisotropic constitutive model. All arteries demonstrated appreciable anisotropy and large nonlinear deformations. Most CCA, SA, TA, AA and CIA specimens were stiffer longitudinally, while most RAs were stiffer circumferentially. A switch in anisotropy was occasionally demonstrated for all arteries. The CCA was the most compliant, least anisotropic and least frequently diseased of all arteries, while the CIA and AA were the stiffest and the most diseased. The severity of atherosclerosis correlated with age, but was not affected by laterality. Elastin fibers in the aorta, SA and CCA were uniformly and mostly circumferentially distributed throughout the media, while in the RA and CIA, elastin was primarily axially aligned and concentrated in the external elastic lamina. Constitutive modeling provided good fits to the experimental data for most arteries. Biomechanical and architectural features of major arteries differ depending on location and functional environment. A better understanding of localized arterial mechanical properties may support the development of site-specific treatment modalities for arterial disease. [ABSTRACT FROM AUTHOR]
Copyright of Biomechanics & Modeling in Mechanobiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Biaxial mechanical properties of the human thoracic and abdominal aorta, common carotid, subclavian, renal and common iliac arteries.
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  Data: <searchLink fieldCode="AR" term="%22Kamenskiy%2C+Alexey%22">Kamenskiy, Alexey</searchLink><relatesTo>1</relatesTo><i> Alexey.Kamenskiy@unmc.edu</i><br /><searchLink fieldCode="AR" term="%22Dzenis%2C+Yuris%22">Dzenis, Yuris</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Kazmi%2C+Syed%22">Kazmi, Syed</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Pemberton%2C+Mark%22">Pemberton, Mark</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Pipinos%2C+Iraklis%22">Pipinos, Iraklis</searchLink><br /><searchLink fieldCode="AR" term="%22Phillips%2C+Nick%22">Phillips, Nick</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Herber%2C+Kyle%22">Herber, Kyle</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Woodford%2C+Thomas%22">Woodford, Thomas</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Bowen%2C+Robert%22">Bowen, Robert</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Lomneth%2C+Carol%22">Lomneth, Carol</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22MacTaggart%2C+Jason%22">MacTaggart, Jason</searchLink><relatesTo>1</relatesTo><i> JMacTaggart@unmc.edu</i>
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  Data: <searchLink fieldCode="JN" term="%22Biomechanics+%26+Modeling+in+Mechanobiology%22">Biomechanics & Modeling in Mechanobiology</searchLink>. Nov2014, Vol. 13 Issue 6, p1341-1359. 19p.
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  Data: <searchLink fieldCode="DE" term="%22Abdominal+aorta%22">Abdominal aorta</searchLink><br /><searchLink fieldCode="DE" term="%22Thoracic+aorta%22">Thoracic aorta</searchLink><br /><searchLink fieldCode="DE" term="%22Iliac+artery%22">Iliac artery</searchLink><br /><searchLink fieldCode="DE" term="%22Biomechanics%22">Biomechanics</searchLink><br /><searchLink fieldCode="DE" term="%22Arterial+diseases%22">Arterial diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Carotid+artery%22">Carotid artery</searchLink><br /><searchLink fieldCode="DE" term="%22Subclavian+artery%22">Subclavian artery</searchLink><br /><searchLink fieldCode="DE" term="%22Renal+artery%22">Renal artery</searchLink>
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  Data: The biomechanics of large- and medium-sized arteries influence the pathophysiology of arterial disease and the response to therapeutic interventions. However, a comprehensive comparative analysis of human arterial biaxial mechanical properties has not yet been reported. Planar biaxial extension was used to establish the passive mechanical properties of human thoracic (TA, $$n=8$$ ) and abdominal (AA, $$n=7$$ ) aorta, common carotid (CCA, $$n=21$$ ), subclavian (SA, $$n=12$$ ), renal (RA, $$n=13$$ ) and common iliac (CIA, $$n=16$$ ) arteries from 11 deceased subjects ( $$54\pm 21$$ years old). Histological evaluation determined the structure of each specimen. Experimental data were used to determine constitutive parameters for a structurally motivated nonlinear anisotropic constitutive model. All arteries demonstrated appreciable anisotropy and large nonlinear deformations. Most CCA, SA, TA, AA and CIA specimens were stiffer longitudinally, while most RAs were stiffer circumferentially. A switch in anisotropy was occasionally demonstrated for all arteries. The CCA was the most compliant, least anisotropic and least frequently diseased of all arteries, while the CIA and AA were the stiffest and the most diseased. The severity of atherosclerosis correlated with age, but was not affected by laterality. Elastin fibers in the aorta, SA and CCA were uniformly and mostly circumferentially distributed throughout the media, while in the RA and CIA, elastin was primarily axially aligned and concentrated in the external elastic lamina. Constitutive modeling provided good fits to the experimental data for most arteries. Biomechanical and architectural features of major arteries differ depending on location and functional environment. A better understanding of localized arterial mechanical properties may support the development of site-specific treatment modalities for arterial disease. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Biomechanics & Modeling in Mechanobiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10237-014-0576-6
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      – Code: eng
        Text: English
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      – SubjectFull: Abdominal aorta
        Type: general
      – SubjectFull: Thoracic aorta
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      – SubjectFull: Iliac artery
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      – SubjectFull: Biomechanics
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      – SubjectFull: Carotid artery
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      – SubjectFull: Subclavian artery
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