In vivo three-dimensional high resolution cardiac diffusion-weighted MRI: A motion compensated diffusion-prepared balanced steady-state free precession approach.
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| Title: | In vivo three-dimensional high resolution cardiac diffusion-weighted MRI: A motion compensated diffusion-prepared balanced steady-state free precession approach. |
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| Authors: | Nguyen, Christopher1,2, Fan, Zhaoyang1, Sharif, Behzad1, He, Yi3, Dharmakumar, Rohan1, Berman, Daniel S.1, Li, Debiao1,2 |
| Source: | Magnetic Resonance in Medicine. Nov2014, Vol. 72 Issue 5, p1257-1267. 11p. |
| Abstract: | Purpose The aim of this study was to implement and optimize a novel application of diffusion-prepared balanced steady-state free precession (bSSFP) to perform in vivo cardiac diffusion-weighted MRI. Theory and Methods Diffusion-prepared sequences have the flexibility to diffusion encode with a multi-shot image readout. The diffusion preparation was optimized to reduce sensitivity to cardiac bulk motion with second order motion compensation (M1M2). The image readout consisted of a three-dimensional (3D) centric-encoded segmented bSSFP acquisition that incorporated a prospective navigator. Ten healthy subjects were scanned twice using the proposed technique diffusion preparation with and without M1M2 using three orthogonal directions under varying off-resonance conditions. Trace apparent diffusion coefficient (trADC) maps and the left ventricular (LV) trADC were calculated. Results M1M2 diffusion-prepared scans resulted in LV trADC values of 1.5 ± 0.4 × 10−3 mm2/s that were reproducible yielding no statistical differences ( P = 0.54). M1M2 diffusion-prepared images showed no ghosting artifacts and/or signal fallout. The non-motion-compensated diffusion-prepared scans yielded LV trADC values of 6.6 ± 0.9 × 10−3 mm2/s and diffusion-prepared images with severe bulk motion-induced artifacts. Conclusion We developed a novel free-breathing bulk motion compensated diffusion-prepared 3D segmented bSSFP technique able to perform in vivo cardiac diffusion-weighted MRI on a conventional clinical MR scanner. Magn Reson Med 72:1257-1267, 2014. © 2013 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR] |
| Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Items | – Name: Title Label: Title Group: Ti Data: In vivo three-dimensional high resolution cardiac diffusion-weighted MRI: A motion compensated diffusion-prepared balanced steady-state free precession approach. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Nguyen%2C+Christopher%22">Nguyen, Christopher</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Fan%2C+Zhaoyang%22">Fan, Zhaoyang</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Sharif%2C+Behzad%22">Sharif, Behzad</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22He%2C+Yi%22">He, Yi</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Dharmakumar%2C+Rohan%22">Dharmakumar, Rohan</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Berman%2C+Daniel+S%2E%22">Berman, Daniel S.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Li%2C+Debiao%22">Li, Debiao</searchLink><relatesTo>1,2</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Nov2014, Vol. 72 Issue 5, p1257-1267. 11p. – Name: Abstract Label: Abstract Group: Ab Data: Purpose The aim of this study was to implement and optimize a novel application of diffusion-prepared balanced steady-state free precession (bSSFP) to perform in vivo cardiac diffusion-weighted MRI. Theory and Methods Diffusion-prepared sequences have the flexibility to diffusion encode with a multi-shot image readout. The diffusion preparation was optimized to reduce sensitivity to cardiac bulk motion with second order motion compensation (M1M2). The image readout consisted of a three-dimensional (3D) centric-encoded segmented bSSFP acquisition that incorporated a prospective navigator. Ten healthy subjects were scanned twice using the proposed technique diffusion preparation with and without M1M2 using three orthogonal directions under varying off-resonance conditions. Trace apparent diffusion coefficient (trADC) maps and the left ventricular (LV) trADC were calculated. Results M1M2 diffusion-prepared scans resulted in LV trADC values of 1.5 ± 0.4 × 10−3 mm2/s that were reproducible yielding no statistical differences ( P = 0.54). M1M2 diffusion-prepared images showed no ghosting artifacts and/or signal fallout. The non-motion-compensated diffusion-prepared scans yielded LV trADC values of 6.6 ± 0.9 × 10−3 mm2/s and diffusion-prepared images with severe bulk motion-induced artifacts. Conclusion We developed a novel free-breathing bulk motion compensated diffusion-prepared 3D segmented bSSFP technique able to perform in vivo cardiac diffusion-weighted MRI on a conventional clinical MR scanner. Magn Reson Med 72:1257-1267, 2014. © 2013 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mrm.25038 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 1257 Titles: – TitleFull: In vivo three-dimensional high resolution cardiac diffusion-weighted MRI: A motion compensated diffusion-prepared balanced steady-state free precession approach. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Nguyen, Christopher – PersonEntity: Name: NameFull: Fan, Zhaoyang – PersonEntity: Name: NameFull: Sharif, Behzad – PersonEntity: Name: NameFull: He, Yi – PersonEntity: Name: NameFull: Dharmakumar, Rohan – PersonEntity: Name: NameFull: Berman, Daniel S. – PersonEntity: Name: NameFull: Li, Debiao IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2014 Type: published Y: 2014 Identifiers: – Type: issn-print Value: 07403194 Numbering: – Type: volume Value: 72 – Type: issue Value: 5 Titles: – TitleFull: Magnetic Resonance in Medicine Type: main |
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