On the Road to Personalized Medicine: Multiscale Computational Modeling of Bone Tissue.
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| Title: | On the Road to Personalized Medicine: Multiscale Computational Modeling of Bone Tissue. |
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| Authors: | Podshivalov, Lev1 podshivalov@ann.jussieu.fr, Fischer, Anath2, Bar-Yoseph, Pinhas2 |
| Source: | Archives of Computational Methods in Engineering. Dec2014, Vol. 21 Issue 4, p399-479. 81p. |
| Subjects: | Individualized medicine, Tissues -- Models, Tissue engineering, Bones, Bone diseases |
| Abstract: | Personalized medicine is an emerging field, considered by many in the biomedical community to be among the upcoming approaches to medical treatment. To embrace this new challenge, physicians need a better understanding of the biological processes in the human body, as well as precise diagnostic tools and patient-specific treatments. In response, the last three decades have witnessed a major shift in tissue engineering development, from treating bone tissue at the macro-scale level only to treating it at complex multiscale levels. Researchers have begun striving for a better understanding of bone structure and mechanics, and then applying this knowledge in designing new medical treatments and procedures. Today computational methods, including finite element analyses, are the tool of choice for biomechanical research of bone tissues. Moreover, bone multiscale modeling can become a vital part of a comprehensive computerized diagnostic system for patient-specific treatment of metabolic bone diseases, fractures and bone cancer. This review paper describes the state of the art in multiscale computational methods used in analyzing bone tissue. The discussed methods and techniques can serve as a base for the creation of such an envisioned diagnostic system. [ABSTRACT FROM AUTHOR] |
| Copyright of Archives of Computational Methods in Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 99218403 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s11831-014-9120-1 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 81 StartPage: 399 Subjects: – SubjectFull: Individualized medicine Type: general – SubjectFull: Tissues -- Models Type: general – SubjectFull: Tissue engineering Type: general – SubjectFull: Bones Type: general – SubjectFull: Bone diseases Type: general Titles: – TitleFull: On the Road to Personalized Medicine: Multiscale Computational Modeling of Bone Tissue. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Podshivalov, Lev – PersonEntity: Name: NameFull: Fischer, Anath – PersonEntity: Name: NameFull: Bar-Yoseph, Pinhas IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2014 Type: published Y: 2014 Identifiers: – Type: issn-print Value: 11343060 Numbering: – Type: volume Value: 21 – Type: issue Value: 4 Titles: – TitleFull: Archives of Computational Methods in Engineering Type: main |
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