Bibliographic Details
| Title: |
Improved bioavailability of vitamin D3 using a β-lactoglobulin-based coagulum. |
| Authors: |
Diarrassouba, Fatoumata1, Garrait, Ghislain2, Remondetto, Gabriel3, Alvarez, Pedro1, Beyssac, Eric2, Subirade, Muriel1 Muriel.Subirade@fsaa.ulaval.ca |
| Source: |
Food Chemistry. Apr2015, Vol. 172, p361-367. 7p. |
| Subjects: |
Bioavailability, Cholecalciferol, Lactoglobulins, Acidification, Proteolytic enzymes |
| Abstract: |
Vitamin D 3 (D 3 ) was encapsulated within a water-soluble matrix, formed by promoting the βlg/D 3 complex by acidification. The capacity of the βlg-based coagulum to increase the long term stability of D 3 in cold storage, upon exposure to intensive UV-light, and in the presence and absence of intestinal proteases, was evaluated. Additionally, the impact of the sequestration of D 3 within the matrix of βlg-based coagulum on its bioavailability was determined in vivo with force-fed rats. The water solubility, long-term storage and UV-light stability of D 3 were significantly increased ( p < 0.0001) due to the high encapsulation efficiency (94.5 ± 1.8%). The βlg-based coagulum was not rapidly disrupted by the proteases in the intestines, leading to a slow release of D 3 , increased uptake of D 3 and subsequent enhancement of the bioavailability of D 3 in rats. [ABSTRACT FROM AUTHOR] |
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| Database: |
Engineering Source |
