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Release of DNA and surfactant from gel particles: The receptor solution effect and the dehydration–hydration aspects.

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Title: Release of DNA and surfactant from gel particles: The receptor solution effect and the dehydration–hydration aspects.
Authors: Mezei, Amalia1, Pons, Ramon1 ramon.pons@iqac.csic.es
Source: Colloids & Surfaces B: Biointerfaces. Nov2014, Vol. 123, p279-285. 7p.
Subjects: Surface active agents, Colloids, Dehydration reactions, Hydration, Solution (Chemistry), Cetyltrimethylammonium bromide
Abstract: DNA and cetyltrimethylammonium bromide (CTAB) have been used to prepare gel particles for controlled release studies. This article reports on the release of DNA and CTAB in four different solutions: in sodium bromide, in strong acid, pH 2 and pH 9 solutions for salmon testes DNA–CTAB gel particles. Also, compares results at extreme acid media and 10 mM NaBr solution with higher molecular weight DNA gel particles. The direct surfactant release was followed for the first time and shows the need of using biocompatible surfactants for the preparation of these gel particles. The release behavior depends on the receptor solution pH and the molecular weight of DNA. The first stage of the release corresponds to the so-called normal release profile and after this period, the release changed to a slow release profile. Also, the effect of dehydration and rehydration on the gel particles structure has been studied for the first time. The last process was observed visually and by SAXS measurements as a function of time. This process maintains the particle membrane integrity, structure and barrier function. The rehydration of dry gel particle in water occurs in only a few hours. [ABSTRACT FROM AUTHOR]
Copyright of Colloids & Surfaces B: Biointerfaces is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 99826413
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Release of DNA and surfactant from gel particles: The receptor solution effect and the dehydration–hydration aspects.
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  Data: <searchLink fieldCode="AR" term="%22Mezei%2C+Amalia%22">Mezei, Amalia</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Pons%2C+Ramon%22">Pons, Ramon</searchLink><relatesTo>1</relatesTo><i> ramon.pons@iqac.csic.es</i>
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  Data: <searchLink fieldCode="JN" term="%22Colloids+%26+Surfaces+B%3A+Biointerfaces%22">Colloids & Surfaces B: Biointerfaces</searchLink>. Nov2014, Vol. 123, p279-285. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Surface+active+agents%22">Surface active agents</searchLink><br /><searchLink fieldCode="DE" term="%22Colloids%22">Colloids</searchLink><br /><searchLink fieldCode="DE" term="%22Dehydration+reactions%22">Dehydration reactions</searchLink><br /><searchLink fieldCode="DE" term="%22Hydration%22">Hydration</searchLink><br /><searchLink fieldCode="DE" term="%22Solution+%28Chemistry%29%22">Solution (Chemistry)</searchLink><br /><searchLink fieldCode="DE" term="%22Cetyltrimethylammonium+bromide%22">Cetyltrimethylammonium bromide</searchLink>
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  Data: DNA and cetyltrimethylammonium bromide (CTAB) have been used to prepare gel particles for controlled release studies. This article reports on the release of DNA and CTAB in four different solutions: in sodium bromide, in strong acid, pH 2 and pH 9 solutions for salmon testes DNA–CTAB gel particles. Also, compares results at extreme acid media and 10 mM NaBr solution with higher molecular weight DNA gel particles. The direct surfactant release was followed for the first time and shows the need of using biocompatible surfactants for the preparation of these gel particles. The release behavior depends on the receptor solution pH and the molecular weight of DNA. The first stage of the release corresponds to the so-called normal release profile and after this period, the release changed to a slow release profile. Also, the effect of dehydration and rehydration on the gel particles structure has been studied for the first time. The last process was observed visually and by SAXS measurements as a function of time. This process maintains the particle membrane integrity, structure and barrier function. The rehydration of dry gel particle in water occurs in only a few hours. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Colloids & Surfaces B: Biointerfaces is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.colsurfb.2014.09.027
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      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 279
    Subjects:
      – SubjectFull: Surface active agents
        Type: general
      – SubjectFull: Colloids
        Type: general
      – SubjectFull: Dehydration reactions
        Type: general
      – SubjectFull: Hydration
        Type: general
      – SubjectFull: Solution (Chemistry)
        Type: general
      – SubjectFull: Cetyltrimethylammonium bromide
        Type: general
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      – TitleFull: Release of DNA and surfactant from gel particles: The receptor solution effect and the dehydration–hydration aspects.
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            NameFull: Mezei, Amalia
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            NameFull: Pons, Ramon
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            – D: 01
              M: 11
              Text: Nov2014
              Type: published
              Y: 2014
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              Value: 09277765
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              Value: 123
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            – TitleFull: Colloids & Surfaces B: Biointerfaces
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