Familiality of Tourette syndrome, obsessive-compulsive disorder, and attention-deficit/hyperactivity disorder: heritability analysis in a large sib-pair sample.
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| Title: | Familiality of Tourette syndrome, obsessive-compulsive disorder, and attention-deficit/hyperactivity disorder: heritability analysis in a large sib-pair sample. |
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| Authors: | Mathews CA (AUTHOR), Grados MA (AUTHOR), Mathews, Carol A1 (AUTHOR), Grados, Marco A (AUTHOR) |
| Source: | Journal of the American Academy of Child & Adolescent Psychiatry. Jan2011, Vol. 50 Issue 1, p46-54. 9p. |
| Abstract: | |
| Copyright of Journal of the American Academy of Child & Adolescent Psychiatry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Education Research Complete |
| FullText | Text: Availability: 0 |
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| Header | DbId: ehh DbLabel: Education Research Complete An: 104977073 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Familiality of Tourette syndrome, obsessive-compulsive disorder, and attention-deficit/hyperactivity disorder: heritability analysis in a large sib-pair sample. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Mathews+CA%22">Mathews CA</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Grados+MA%22">Grados MA</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mathews%2C+Carol+A%22">Mathews, Carol A</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Grados%2C+Marco+A%22">Grados, Marco A</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry%22">Journal of the American Academy of Child & Adolescent Psychiatry</searchLink>. Jan2011, Vol. 50 Issue 1, p46-54. 9p. – Name: Abstract Label: Abstract Group: Ab Data: <bold>Objective: </bold>Tourette syndrome (TS) is a neuropsychiatric disorder with a genetic component that is highly comorbid with obsessive-compulsive disorder (OCD) and attention deficit/hyperactivity disorder (ADHD). However, the genetic relations between these disorders have not been clearly elucidated. This study examined the familial relations among TS, OCD, and ADHD in a large sample of TS families.<bold>Method: </bold>Parent-offspring concordance of TS, OCD, and ADHD was examined in 952 individuals from 222 TS-affected sib-pair families originally collected for genetic studies using logistic regression with generalized estimating equations to control for correlated data. Variance components methods were used to estimate the heritability and genetic and environmental correlations among TS, OCD, and ADHD. Bilineal families where both parents had TS or OCD were excluded.<bold>Results: </bold>OCD and ADHD were highly heritable in these TS families. There were significant genetic correlations between TS and OCD and between OCD and ADHD, but not between TS and ADHD. In addition, significant environmental correlations were found between TS and ADHD and between OCD and ADHD. Parental OCD + ADHD was associated with offspring OCD + ADHD.<bold>Conclusions: </bold>This study provides further evidence for a genetic relation between TS and OCD and suggests that the observed relation between TS and ADHD may due in part be to a genetic association between OCD and ADHD and in part due to shared environmental factors. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of the American Academy of Child & Adolescent Psychiatry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.jaac.2010.10.004 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 46 Titles: – TitleFull: Familiality of Tourette syndrome, obsessive-compulsive disorder, and attention-deficit/hyperactivity disorder: heritability analysis in a large sib-pair sample. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Mathews CA – PersonEntity: Name: NameFull: Grados MA – PersonEntity: Name: NameFull: Mathews, Carol A – PersonEntity: Name: NameFull: Grados, Marco A IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2011 Type: published Y: 2011 Identifiers: – Type: issn-print Value: 08908567 Numbering: – Type: volume Value: 50 – Type: issue Value: 1 Titles: – TitleFull: Journal of the American Academy of Child & Adolescent Psychiatry Type: main |
| ResultId | 1 |
