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Impact of childhood trauma on treatment outcome in the Treatment for Adolescents with Depression Study (TADS).

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Title: Impact of childhood trauma on treatment outcome in the Treatment for Adolescents with Depression Study (TADS).
Authors: Lewis CC (AUTHOR), Simons AD (AUTHOR), Nguyen LJ (AUTHOR), Murakami JL (AUTHOR), Reid MW (AUTHOR), Silva SG (AUTHOR), March JS (AUTHOR), Lewis, Cara C1 (AUTHOR), Simons, Anne D (AUTHOR), Nguyen, Lananh J (AUTHOR), Murakami, Jessica L (AUTHOR), Reid, Mark W (AUTHOR), Silva, Susan G (AUTHOR), March, John S (AUTHOR)
Source: Journal of the American Academy of Child & Adolescent Psychiatry. Feb2010, Vol. 49 Issue 2, p132-140. 9p.
Abstract: Objective: The impact of childhood trauma was examined in 427 adolescents (54% girls, 74% Caucasian, mean = 14.6, SD = 1.5) with major depressive disorder participating in the Treatment for Adolescents with Depression Study (TADS).Method: TADS compared the efficacy of cognitive behavioral therapy (CBT), fluoxetine (FLX), their combination (COMB), and placebo (PBO). Teens were separated into four trauma history groups: (1) no trauma; (2) trauma, no abuse; (3) physical abuse; (4), and sexual abuse. The effects of treatment and trauma history on depression severity across 12 weeks of acute treatment, as measured by the Children's Depression Rating Scale-Revised (CDRS-R), were examined.Results: A significant trauma-by-treatment-by-time interaction indicated that trauma history moderated treatment. The Week 12 primary efficacy findings previously reported by TADS were replicated in the no trauma group (n = 201): COMB = FLX > CBT = PBO. No significant differences in treatment arms were observed among the trauma, no abuse, or physical abuse group. Teens with a history of sexual abuse treated with COMB, FLX, and PBO showed significant and equivalent improvement on the CDRS-R (mean <45), whereas the mean CDRS-R for the CBT group tended to remain in the depressed range (mean >45). Baseline suicidality and self-reported depression were significantly related to a history of sexual abuse.Conclusions: The study was limited by the level of detail regarding childhood traumatic experiences. Results are discussed in terms of the implications for treating depressed adolescents with traumatic backgrounds.Clinical Trials Registry Information: Treatment for Adolescents with Depression Study; http://www.clinicaltrials.gov, NCT00006286. [ABSTRACT FROM AUTHOR]
Copyright of Journal of the American Academy of Child & Adolescent Psychiatry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Impact of childhood trauma on treatment outcome in the Treatment for Adolescents with Depression Study (TADS).
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lewis+CC%22&quot;&gt;Lewis CC&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Simons+AD%22&quot;&gt;Simons AD&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Nguyen+LJ%22&quot;&gt;Nguyen LJ&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Murakami+JL%22&quot;&gt;Murakami JL&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Reid+MW%22&quot;&gt;Reid MW&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Silva+SG%22&quot;&gt;Silva SG&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22March+JS%22&quot;&gt;March JS&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lewis%2C+Cara+C%22&quot;&gt;Lewis, Cara C&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Simons%2C+Anne+D%22&quot;&gt;Simons, Anne D&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Nguyen%2C+Lananh+J%22&quot;&gt;Nguyen, Lananh J&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Murakami%2C+Jessica+L%22&quot;&gt;Murakami, Jessica L&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Reid%2C+Mark+W%22&quot;&gt;Reid, Mark W&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Silva%2C+Susan+G%22&quot;&gt;Silva, Susan G&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22March%2C+John+S%22&quot;&gt;March, John S&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry%22&quot;&gt;Journal of the American Academy of Child &amp; Adolescent Psychiatry&lt;/searchLink&gt;. Feb2010, Vol. 49 Issue 2, p132-140. 9p.
– Name: Abstract
  Label: Abstract
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  Data: &lt;bold&gt;Objective: &lt;/bold&gt;The impact of childhood trauma was examined in 427 adolescents (54% girls, 74% Caucasian, mean = 14.6, SD = 1.5) with major depressive disorder participating in the Treatment for Adolescents with Depression Study (TADS).&lt;bold&gt;Method: &lt;/bold&gt;TADS compared the efficacy of cognitive behavioral therapy (CBT), fluoxetine (FLX), their combination (COMB), and placebo (PBO). Teens were separated into four trauma history groups: (1) no trauma; (2) trauma, no abuse; (3) physical abuse; (4), and sexual abuse. The effects of treatment and trauma history on depression severity across 12 weeks of acute treatment, as measured by the Children&#39;s Depression Rating Scale-Revised (CDRS-R), were examined.&lt;bold&gt;Results: &lt;/bold&gt;A significant trauma-by-treatment-by-time interaction indicated that trauma history moderated treatment. The Week 12 primary efficacy findings previously reported by TADS were replicated in the no trauma group (n = 201): COMB = FLX &gt; CBT = PBO. No significant differences in treatment arms were observed among the trauma, no abuse, or physical abuse group. Teens with a history of sexual abuse treated with COMB, FLX, and PBO showed significant and equivalent improvement on the CDRS-R (mean &lt;45), whereas the mean CDRS-R for the CBT group tended to remain in the depressed range (mean &gt;45). Baseline suicidality and self-reported depression were significantly related to a history of sexual abuse.&lt;bold&gt;Conclusions: &lt;/bold&gt;The study was limited by the level of detail regarding childhood traumatic experiences. Results are discussed in terms of the implications for treating depressed adolescents with traumatic backgrounds.Clinical Trials Registry Information: Treatment for Adolescents with Depression Study; http://www.clinicaltrials.gov, NCT00006286. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Journal of the American Academy of Child &amp; Adolescent Psychiatry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1097/00004583-201002000-00007
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              Text: Feb2010
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